Results 31 to 40 of about 14,721 (198)

Integrative single cell RNA‐sequencing and spatial transcriptomics uncovers distinct macrophage‐fibroblast cross‐talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objectives Femoroacetabular impingement (FAI) and synovitis have been recognized as essential factors for developing osteoarthritis (OA) in the hip joints. However, little is known about altered synovial cellular compositions, their associated transcriptomic profiles, and cell‐cell interactions in FAI and hip OA.
Gulzada Kulzhanova, Alexis Klee, Mina Botros, Victoria L. Hansen, John Reuter, Eliya Tazreena Tashbib, Eloise Fadial, Benjamin F. Ricciardi, Brian Giordano, Chia‐Lung Wu   +9 more
wiley   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Atypical mast cells and multiple myeloma: An ambiguous alliance with diagnostic implications. [PDF]

Br J Haematol
British Journal of Haematology, Volume 208, Issue 3, Page 817-818, March 2026.
Rieu JB, Schavgoulidze A, Canali A, Largeaud L, Perrot A, Syrykh C.   +5 more
europepmc   +2 more sources

Characterization of CD123 expression by mast cells in systemic mastocytosis with multicolor flow cytometry

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Systemic mastocytosis (SM) is a clonal mast cell (MC) disorder characterized by aberrant immunophenotypes, including expression of CD25, CD2, and occasionally CD30. CD123, the α‐subunit of the interleukin‐3 receptor, is a therapeutic target in hematologic malignancies and has been reported to be expressed on neoplastic MCs by ...
Ryan C. Shean, Tracy I. George, David P. Ng   +2 more
wiley   +1 more source

Effect of tryptase inhibition on joint inflammation: a pharmacological and lentivirus-mediated gene transfer study

Arthritis Research & Therapy, 2017
Background Increasing evidences indicate that an unbalance between tryptases and their endogenous inhibitors, leading to an increased proteolytic activity, is implicated in the pathophysiology of rheumatoid arthritis.
Alexandre Denadai-Souza, Camilla Moreira Ribeiro, Corinne Rolland, Anne Thouard, Céline Deraison, Cristoforo Scavone, Daniel Gonzalez-Dunia, Nathalie Vergnolle, Maria Christina Werneck Avellar   +8 more
doaj   +1 more source

Tryptase activation of immortalized human urothelial cell mitogen-activated protein kinase. [PDF]

PLoS ONE, 2013
The pathogenesis of interstitial cystitis/painful bladder syndrome (IC/PBS) is multifactorial, but likely involves urothelial cell dysfunction and mast cell accumulation in the bladder wall.
John O Marentette, Paul J Hauser, Robert E Hurst, David J Klumpp, Alice Rickard, Jane McHowat   +5 more
doaj   +1 more source

mMCP7, a Mouse Ortholog of δ Tryptase, Mediates Pelvic Tactile Allodynia in a Model of Chronic Pelvic Pain

Frontiers in Pain Research, 2022
Chronic prostatitis/Chronic pelvic pain syndrome (CP/CPPS) is a condition that affects a large number of men and has unknown etiology. We have previously demonstrated the presence of elevated levels of mast cell tryptase in expressed prostatic secretions
Goutham Pattabiraman, Zhiqiang Liu, Madhumita Paul, Anthony J. Schaeffer, Praveen Thumbikat   +4 more
doaj   +1 more source

Biochemical and Functional Characterization of Human Transmembrane Tryptase (TMT)/Tryptase γ [PDF]

Journal of Biological Chemistry, 2002
Transmembrane tryptase (TMT)/tryptase γ is a membrane-bound serine protease stored in the secretory granules of human and mouse lung mast cells (MCs).
Wong, Guang, Foster, Paul S, Yasuda, Shinsuke, Qi, Jian, Mahalingam, Surendran, Mellor, Elizabeth, Katsoulotos, Gregory, Li, Lixin, Boyce, Joshua, Krilis, Steven, Stevens, Richard   +10 more
openaire   +2 more sources

The Role of Artificial Intelligence in Modern Allergology: A Review of Applications in Diagnosis, Prediction, and Management

JEADV Clinical Practice, EarlyView.
ABSTRACT Artificial Intelligence is rapidly transforming allergology by enhancing diagnosis, risk prediction, automation, patient communication, education, and therapy development. Machine learning approaches, including convolutional neural networks, recurrent architectures, and transformer‐based models, enable analysis of complex datasets from ...
Sebastian Seurig, Stephan Traidl, Sonja Mathes   +2 more
wiley   +1 more source