Results 61 to 70 of about 14,721 (198)

Markedly Increased Diamine Oxidase During Acute Anaphylaxis Is Associated With an Underlying Clonal Mast Cell Disorder

Clinical &Experimental Allergy, EarlyView.
We provide the first evidence that pronounced release of DAO during anaphylaxis is restricted to patients with clonal mast cell disorder. This finding offers possible functional support for the reported association between KIT p.D816V and anaphylaxis severity.
Matija Rijavec, Žan Kogovšek, Jezerka Inkret, Peter Kopač, Mitja Košnik, Peter Korošec   +5 more
wiley   +1 more source

Distinct Tryptase Gene Copy Number Variations Correlate With Tryptase Levels in a Population‐Based Cohort

Allergy, EarlyView.
Yannick Chantran, Simone Choi, Céline Roda, Stéphane Barete, Pierre Hirsch, Olivier Hermine, Laura Polivka, Julien Rossignol, Michel Arock, Fanny Rancière, Isabelle Momas   +10 more
wiley   +1 more source

AllergoOncology in Review: Harnessing Allergy in the Field of Oncology to Improve Patient Outcomes

Clinical &Experimental Allergy, EarlyView.
ABSTRACT The AllergoOncology field brings together the study of allergic and cancer immune responses, having evolved from early epidemiological studies that reported inverse associations between allergies, IgE and cancer risk. Insights from studying allergic inflammation are revealing previously unappreciated immune mechanisms that confer protective ...
Jakub Zydron, Anishaa Balaji, Jitesh Chauhan, Jack Alder, Xinyi Chen, Anna M. F. Wiegman, Aurelie Poli, Joanna Jacków‐Malinowska, Jack Cheeseman, Daniel I. R. Spencer, James McDonnell, James Spicer, Alexandra J. McCraw, Sophia N. Karagiannis   +13 more
wiley   +1 more source

Correspondence to ‘Hypersensitivity Reactions to Human Albumin—A Case Series and Diagnostic Algorithm’

Allergy, EarlyView.
Juliette Charpy, Mathilde Seydoux, Antoine Giraudon, Julien Bonnac, Maxime Dubois, Maryline Bordes‐Demolis, Christelle Pellerin, Julien Goret   +7 more
wiley   +1 more source

A Pilot Randomised Controlled Dose‐Ranging Trial of Ant Venom Immunotherapy With and Without Delta‐Inulin Adjuvant

Clinical &Experimental Allergy, EarlyView.
Low dose (25mcg) jack jumper ant venom immunotherapy with or without Advax adjuvant, had similar efficacy to the current standard of care. Reduction in basophil activation test reactivity in response to treatment correlated with sting challenge outcome.
Thanh‐Thao Adriana Le, Troy Wanandy, Griffith B. Perkins, Susan Lester, Wun Yee Lau, Malcolm Turner, Richard J. Woodman, Emily M. Mulcahy, Sherin Vareeckal Joseph, Shweta Mhatre, Simon G. A. Brown, Michael D. Wiese, Nikolai Petrovsky, Robert J. Heddle, Pravin Hissaria   +14 more
wiley   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Involvement of premacular mast cells in the pathogenesis of macular diseases.

PLoS ONE, 2019
We previously reported on the elevated intravitreal activities of tryptase and chymase in association with idiopathic epiretinal membrane (ERM) and idiopathic macular hole (MH).
Takaki Sato, Seita Morishita, Taeko Horie, Masanori Fukumoto, Teruyo Kida, Hidehiro Oku, Kimitoshi Nakamura, Shinji Takai, Denan Jin, Tsunehiko Ikeda   +9 more
doaj   +1 more source

Legends of Allergy—Lawrence B. Schwartz

Allergy, EarlyView.
Gunnar P. Nilsson
wiley   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Pediatric anaphylaxis in the emergency department: Performances of dynamic tryptase measurement

Journal of Allergy and Clinical Immunology: Global
Background: Dynamic measurement of serum acute (sAT) and baseline (sBT) tryptase confirms mast cell degranulation during systemic hypersensitivity reactions, provided timing and interpretation are appropriate.
Constance Gonzalez, MD, Meng Sun, MSc, Aurélie Morand, MD, PhD, Philippe Minodier, MD, Marc Leone, MD, PhD, Jean-Christophe Dubus, MD, PhD, Joana Vitte, MD, PhD, Moïse Michel, PharmD, PhD   +7 more
doaj   +1 more source