Results 11 to 20 of about 1,269 (154)

Extended cleavage specificities of human granzymes A and K, two closely related enzymes with conserved but still poorly defined functions in T and NK cell-mediated immunity

Frontiers in Immunology, 2023
Granzymes A and K are two highly homologous serine proteases expressed by mammalian cytotoxic T cells (CTL) and natural killer cells (NK). Granzyme A is the most abundant of the different granzymes (gzms) expressed by these two cell types.
Erdem Aybay, Jinhye Ryu, Zhirong Fu, Srinivas Akula, Srinivas Akula, Erika Mendez Enriquez, Jenny Hallgren, Sara Wernersson, Anna-Karin Olsson, Lars Hellman   +9 more
doaj   +1 more source

Histamine Is Responsible for the Neuropathic Itch Induced by the Pseudorabies Virus Variant in a Mouse Model

Viruses, 2022
Pseudorabies virus (PRV) is the causative agent of pseudorabies (PR). It can infect a wide range of mammals. PRV infection can cause severe acute neuropathy (the so-called “mad itch”) in nonnatural hosts. PRV can infect the peripheral nervous system (PNS)
Bing Wang, Hongxia Wu, Hansong Qi, Hanglin Li, Li Pan, Lianfeng Li, Kehui Zhang, Mengqi Yuan, Yimin Wang, Hua-Ji Qiu, Yuan Sun   +10 more
doaj   +1 more source

Different levels of mucus inflammatory mediators in nasal polyposis with and without aeroallergen sensitivity

Laryngoscope Investigative Otolaryngology, 2022
Objectives Biomarker levels in nasal secretions can reflect the inflammatory status of nasal mucosa and evolution of sinus disease. The aim of this study was to evaluate the relationship between local inflammatory mediator production and clinical ...
Aleksandar Dimić, Aleksandar Perić, Uglješa Grgurević, Jelena Sotirović, Milica Labus, Nenad Baletić, Milanko Milojević, Ivan Stanojević, Danilo Vojvodić   +8 more
doaj   +1 more source

Immunoelectron microscopy study of superficial skin nerves in drug-induced acute urticaria Estudo de microscopia imunoeletrônica dos nervos superficiais da pele na urticária aguda induzida por medicamentos

Anais Brasileiros de Dermatologia, 2012
BACKGROUND: Few studies have evaluated the ultrastructure of the superficial skin nerves in urticaria. OBJECTIVE: The objective of this study was to describe findings in superficial skin nerves in cases of drug-induced acute urticaria.
Paulo Ricardo Criado, Roberta Fachini Jardim Criado, Cleusa F.H. Takakura, Carla Pagliari, Mirian Nacagami Sotto, Cidia Vasconcellos   +5 more
doaj   +1 more source

Immune responses in fatalities involving opioids

Forensic Sciences Research, 2019
In some cases of fatalities involving opioid use, the concentrations of detected opioids are not in the toxic range. Immune reactions can be triggered by opioid use, suggesting that immune response may be a factor in these cases.
Henry J. Carson
doaj   +1 more source

Mast cell tryptase and asthma [PDF]

Mediators of Inflammation, 1997
Recent physiological and pharmacological studies have indicated the potential importance of tryptase, the major protein component in mast cells, in inflammatory diseases (especially asthma). Being released at inflammatory sites after the activation of mast cells, tryptase is capable of causing bronchohyperresponsiveness and infiltration of eosinophils,
Zhang, M.Q., Timmerman, H.
openaire   +4 more sources

Relationship between Tryptase and Type 2 Diabetes Mellitus with Macrovascular Complications: a Ten-year Follow-up Study [PDF]

Zhongguo quanke yixue
Background Diabetic macrovascular complications represent prevalent and severe consequences of diabetes mellitus, characterized by high morbidity and significant clinical impact. To date, the pathogenesis of the disease remains undefined.
ZHAO Ya, WAN Qin
doaj   +1 more source

Effect of tryptase inhibition on joint inflammation: a pharmacological and lentivirus-mediated gene transfer study

Arthritis Research & Therapy, 2017
Background Increasing evidences indicate that an unbalance between tryptases and their endogenous inhibitors, leading to an increased proteolytic activity, is implicated in the pathophysiology of rheumatoid arthritis.
Alexandre Denadai-Souza, Camilla Moreira Ribeiro, Corinne Rolland, Anne Thouard, Céline Deraison, Cristoforo Scavone, Daniel Gonzalez-Dunia, Nathalie Vergnolle, Maria Christina Werneck Avellar   +8 more
doaj   +1 more source

Tracing the Origins of IgE, Mast Cells, and Allergies by Studies of Wild Animals

Frontiers in Immunology, 2017
In most industrialized countries, allergies have increased in frequency quite dramatically during the past 50 years. Estimates show that 20–30% of the populations are affected.
Lars Torkel Hellman, Srinivas Akula, Michael Thorpe, Zhirong Fu   +3 more
doaj   +1 more source

Tryptase and Protease-Activated Receptor 2 Expression Levels in Irritable Bowel Syndrome

Gut and Liver, 2016
Background/AimsPrevious studies have revealed that mast cells (MCs) may activate the protease-activated receptors and release of neuropeptides involved in the pathogenesis of irritable bowel syndrome (IBS).
doaj   +1 more source