Results 101 to 110 of about 306,090 (270)
Evaluating force field accuracy with long-time simulations of a tryptophan zipper peptide [PDF]
, 2010 We have combined a custom implementation of the fast multiple-time-stepping LN integrator with parallel tempering to explore folding properties of small peptides in implicit solvent on the time scale of microseconds. We applied this algorithm to the synthetic {\beta}-hairpin trpzip2 and one of its sequence variants W2W9.
arxiv +1 more source
Two Adjacent Phenylalanines In the NMDA Receptor GluN2A Subunit M3 Domain Interactively Regulate Alcohol Sensitivity and Ion Channel Gating [PDF]
, 2017 The N-methyl-d-aspartate (NMDA) receptor is a key target of ethanol action in the central nervous system. Alcohol inhibition of NMDA receptor function involves small clusters of residues in the third and fourth membrane-associated (M) domains.
Dwyer, Donard S. +4 more
core +2 more sources
A superconducting NbN detector for neutral nanoparticles [PDF]
Nanotechnology 20, 45501, 2009, 2014 We present a proof-of-principle study of superconducting single photon detectors (SSPD) for the detection of individual neutral molecules/nanoparticles at low energies. The new detector is applied to characterize a laser desorption source for biomolecules and it allows to retrieve the arrival time distribution of a pulsed molecular beam containing the ...
arxiv +1 more source
Regulation of the \u3cem\u3eEscherichia coli\u3c/em\u3e Tryptophan Operon by Early Reactions in the Aromatic Pathway [PDF]
, 1970 7-Methyltryptophan (7MT) or compounds which can be metabolized to 7MT, 3-methylanthranilic acid (3MA) and 7-methylindole, cause derepression of the trp operon through feedback inhibition of anthranilate synthetase. Tyrosine reverses 3MA or 7-methylindole
Held, William A., Smith, Oliver H.
core +1 more source
Tryptophan Metabolic Pathways and Brain Serotonergic Activity: A Comparative Review
Frontiers in Endocrinology, 2019 The essential amino acid L-tryptophan (Trp) is the precursor of the monoaminergic neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). Numerous studies have shown that elevated dietary Trp has a suppressive effect on aggressive behavior and post ...
E. Höglund, Ø. Øverli, S. Winberg
semanticscholar +1 more source
Journal of Biological Chemistry, 1975 We investigated how changes in tryptophan pyrrolase activity and tryptophan loads affect the breakdown of tryptophan was estimated by injecting rats with [ring-2-14-C]tryptophan and measuring respiratory 14-CO2. We concluded, contrary to previous reports, that induction of tryptophan pyrrolase definitely will increase the rate of tryptophan breakdown ...
S N Young, T L Sourkes
openaire +3 more sources
Tryptophan in Nutrition and Health
International Journal of Molecular Sciences, 2022 Tryptophan is a rate-limiting essential amino acid and a unique building block of peptides and proteins [...]
Poeggeler, Burkhard +5 more
openaire +3 more sources
The effect of 3-indoleacetic acid on the response of Lactobacillus arabinosus 17-5 to nicotinamide [PDF]
, 1949 Lactobacillus arabinosus 17-5 has been widely used as an assay organism for nicotinic acid (NA) since the development of the method by Snell and Wright (1). Although it has been realized that other substances present in tissue extracts may interfere with
Galston, Arthur W., Hand, Margery E.
core
Nutrients, 2016 The serotonergic system forms a diffuse network within the central nervous system and plays a significant role in the regulation of mood and cognition.
T. Jenkins +3 more
semanticscholar +1 more source
The Feasibility of Coherent Energy Transfer in Microtubules [PDF]
Journal of The Royal Society Interface 2014, 11: 20140677, 2014 It was once purported that biological systems were far too warm and wet to support quantum phenomena mainly due to thermal effects disrupting quantum coherence. However recent experimental results and theoretical analyses have shown that thermal energy may assist, rather than disrupt, quantum coherence, especially in the dry hydrophobic interiors of ...
arxiv +1 more source