Results 91 to 100 of about 301,590 (287)

Sequence Permutation Generated Lysine and Tryptophan-Rich Antimicrobial Peptides with Enhanced Therapeutic Index

Antibiotics
Background/Objectives: Antimicrobial peptides (AMPs) are promising therapeutic agents due to their broad-spectrum activity against bacteria, viruses, and fungi.
Kuang-Li Peng, Yu-Hsuan Wu, Hsuan-Che Hsu, Jya-Wei Cheng   +3 more
doaj   +1 more source

Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy

Advanced Science, EarlyView.
This modular, site‐specific antibody platform enables customizable conjugates for PET imaging and therapy. Interchangeable payloads – including radiometals, cytotoxics, and fluorophores – support adaptable, multimodal applications with limited off‐target effects. In vivo, the DFO/DOTAGA bischelate immunoconjugate provided clear tumor delineation in PET/
Delphine Vivier, Megane Grah Kple, Julen Ariztia, Marion Leroux, Mathieu Moreau, Michael Claron, Maxime Cheveau, Adam Laouafa, Agnieszka Kownacka, Camille Petitot, John Simonet, Alexandre M. M. Dias, Sophie Poty, Charles Truillet, Bertrand Collin, Alexandra Oudot, Franck Denat   +16 more
wiley   +1 more source

The gut microbiota and its metabolites: novel therapeutic targets for inflammatory bowel disease

Frontiers in Immunology
Inflammatory bowel disease (IBD) pathogenesis is critically influenced by gut microbiota dysbiosis and perturbations in associated metabolites. This review outlines current IBD diagnostic and therapeutic paradigms, highlighting the persistent focus on ...
Xingyu Shen, Xingyu Shen, Yue Li, Yue Li, Deqiang Wang, Kang Sun   +5 more
doaj   +1 more source

Tryprophan metbolism in alcoholism. Tryptophan but not excitatory amino acid availablity to the brain is increased before the appearance of the alcohol-withdrawal syndrome in men [PDF]

, 1998
Tryptophan (Trp) metabolism and disposition and excitatory and other amino acid concentrations were determined in alcohol-dependent subjects in relation to the alcohol-withdrawal syndrome (AWS).
Morgan, Christopher J., Spies, Claudia D., Badaway, Abdulla A.-B, Blum, Susanne, Ehlert, Annette, Rommelspacher, Hans, Bonner, Adrian B., Bradley, Don M.   +7 more
core  

837824_Suppl_Tables – Supplemental material for Safe cross-clamp time using Custodiol®–histidine-tryptophan-ketoglutarate cardioplegia in the adult

, 2019
Supplemental material, 837824_Suppl_Tables for Safe cross-clamp time using Custodiol®–histidine-tryptophan-ketoglutarate cardioplegia in the adult by Giuseppe Gatti, Elisabetta Rauber, Gabriella Forti, Bernardo Benussi, Marco Gabrielli, Carla Gripari ...
Carla Gripari (6527174), Aniello Pappalardo (6527180), Gabriella Forti (6527165), Elisabetta Rauber (6527162), Giuseppe Gatti (1859509), Gianfranco Gustin (6527177), Marco Gabrielli (6527171), Bernardo Benussi (6527168)   +7 more
core   +1 more source

Nickel‐Catalyzed Three‐Component Difluoroalkylation‐Amination for the Direct Access to Anti‐Inflammatory β‐Difluoroalkyl Amines

Advanced Science, EarlyView.
A nickel‐catalyzed three‐component reductive fluoroalkylation‐amination strategy of N‐vinylamides for the direct access to the α‐amidyl‐β‐difluoroalkyl amines was reported here. The synthetic method features with broad substrate scope, mild conditions, high functional group tolerance, and convenience to handle.
Chang Xu, Fangting Ma, Fan Ding, Luyan Wang, Yunxi Li, Yunzhi He, Xingang Zhang, Siyu He, Dandan Liu   +8 more
wiley   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

Meat productivity and beef quality of Black-and-White bulls fed with zinc and selenium in organic form as part of the diet

Аграрная наука Евро-Северо-Востока
Increasing the production of high quality ecologically pure animal products, especially beef is one of the main tasks of the agro-industrial complex. In this regard, it is necessary to apply measures for the effective use of genetic resources of both ...
A. V. Kharlamov, A. N. Frolov, V. V. Ilyin   +2 more
doaj   +1 more source

Synthesis and Structure−Activity Relationships of 2-Substituted d-Tryptophan-Containing Peptidic Endothelin Receptor Antagonists:  Importance of the C-2 Substituent of the d-Tryptophan Residue for Endothelin A and B Receptor Subtype Selectivity

, 2016
Continuing studies on modifications of potent cyclic pentapeptide endothelin (ET) receptor antagonists, represented by BQ-123, and potent linear tripeptide derivative ET receptor antagonists, represented by BQ-788, are described herein.
Satoshi Ozaki (1768822), Takehiro Fukami (1266522), Kenji Niiyama (3018435), Yuuka Amano (3018441), Takahiro Fukuroda (2430631), Takeru Yamakawa (3018429), Masaki Ihara (442198), Kiyofumi Ishikawa (3018432), Hisaki Kojima (3009789), Fuyuko Kanda (3018426), Mitsuo Yano (3018438)   +10 more
core   +1 more source

Covalently Linked Peptides and Membrane Potential Enable CyaA Segment Translocation

Advanced Science, EarlyView.
Using a newly developed Droplet Interface Bilayer‐Pipette assay, the authors show that two segments of the CyaA toxin cross membranes by distinct mechanisms. One segment translocates spontaneously, whereas the translocation of the other depends on membrane potential.
Gaia Scilironi, Nicolas Carvalho, Jacinthe Frangieh, Corentin Léger, Dorothée Raoux‐Barbot, J. Iñaki Guijarro, Daniel Ladant, Sophie Cribier, Nicolas Rodriguez, Alexandre Chenal   +9 more
wiley   +1 more source