Results 71 to 80 of about 301,590 (287)
Structural insights into the basis and evolution of interactions in multi-subunit protein assemblies. tryptophan synthase and titin FNIII-repeats [PDF]
, 2008 Cellular processes benefit from evolutionary shaping when optimized protein-protein interactions result in enhanced functionality. In fact, most cellular proteins are tightly embedded into biological networks that function following a modularity ...
Bucher, Rainer Michael
core +1 more source
Advanced Materials Interfaces, EarlyView.UV–vis fluorescence spectroscopy enables sensitive monitoring of plant protein adsorption on AISI 316L stainless steel under food‐processing‐relevant conditions. Spectral deconvolution reveals adsorption‐induced changes associated with protein–surface interactions and conformational alterations, demonstrating the potential of the technique for ...
Alexander Khort +6 more
wiley +1 more source
Advanced Science, EarlyView.Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García +13 more
wiley +1 more source
Dichlorinated and Brominated Rugulovasines, Ergot Alkaloids Produced by Talaromyces wortmannii
Molecules, 2015 UHPLC-DAD-HRMS based dereplication guided the detection of new halogenated alkaloids co-produced by Talaromyces wortmannii. From the fungal growth in large scale, the epimers 2,8-dichlororugulovasines A and B were purified and further identified by means
Lívia Soman de Medeiros +9 more
doaj +1 more source
Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis
Advanced Science, EarlyView.Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang +9 more
wiley +1 more source
PyrH and PrnB crystal structures [PDF]
, 2006 Determination of the three-dimensional structure of enzymes at atomic resolution is a key prerequisite for elucidation of molecular mechanisms of catalysis and catalysis mechanism prediction.
De Laurentis, Walter
core +2 more sources
Gut MicrobesThe gut microbiota plays a pivotal role in anxiety regulation through pathways involving neurotransmitter production, immune signaling, and metabolic interactions.
Miaomiao Pan +16 more
doaj +1 more source
Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile [PDF]
, 2014 Tryptophan is an important precursor for chemical entities that ultimately support the biosynthesis of key metabolites. The second stage of tryptophan catabolism is catalysed by kynurenine formamidase, an enzyme that is different between eukaryotes and ...
Zoltner, Martin +3 more
core +1 more source
Tryptophan-PNA gc Conjugates Self-Assemble to Form Fibers
, 2023 Peptide nucleic acids and their conjugates to peptides can self-assemble and generate complex architectures. In this work, we explored the self-assembly of PNA dimers conjugated to the dipeptide WW.
Marilisa Leone (1479286) +11 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang +18 more
wiley +1 more source