Results 51 to 60 of about 418,334 (279)

Dip2a regulates stress susceptibility in the basolateral amygdala

Neural Regeneration Research
Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters.
Jing Li, Zixuan He, Weitai Chai, Meng Tian, Huali Yu, Xiaoxiao He, Xiaojuan Zhu   +6 more
doaj   +1 more source

Effect of Chitosan and Amphiphilic Polymers on the Photosensitizing and Spectral Properties of Rose Bengal

Molecules, 2022
The influence of chitosan (CS) and amphiphilic polymers (AP: pluronic F108 and polyvinylpyrrolidone (PVP)) on the photocatalytic activity of rose bengal (RB) in a model reaction of tryptophan photo-oxidation in phosphate-buffered saline (PBS) was studied.
Anastasia S. Kuryanova, Marina A. Savko, Vladislav S. Kaplin, Nadezhda A. Aksenova, Victoria A. Timofeeva, Aleksandr V. Chernyak, Nicolay N. Glagolev, Petr S. Timashev, Anna B. Solovieva   +8 more
doaj   +1 more source

Different Sites of Alcohol Action in the NMDA Receptor GluN2A and GluN2B Subunits [PDF]

, 2015
The NMDA receptor is a major target of alcohol action in the CNS, and recent behavioral and cellular studies have pointed to the importance of the GluN2B subunit in alcohol action.
Allgaier, Alvestad, Anders, Anders, Boyce-Rustay, Chandrasekar, Chu, Dingledine, Donard S. Dwyer, Dopico, Dwyer, Erreger, Gass, Gonzales, Göthert, Hoffman, Holmes, Hong Ren, Honse, Izumi, Karakas, Kash, Kash, Kash, Koob, Krishnan-Sarin, Krupitsky, Krystal, Kuner, Lima-Landman, Lovinger, Low, Low, Masood, Mihic, Moykkynen, Nagy, Peoples, Peoples, Peoples, Popp, Ren, Ren, Ren, Ren, Ren, Ren, Robert W. Peoples, Ronald, Salous, Smothers, Smothers, Smothers, Sobolevsky, Sobolevsky, Vengeliene, Vengeliene, Wang, Weiss, Wick, Wills, Woodward, Woodward, Wright, Xu, Xu, Yamakura, Yuan, Yulin Zhao   +68 more
core   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

The Kynurenine Pathway in Obese Middle-Aged Women with Normoglycemia and Type 2 Diabetes

Metabolites, 2022
We examined the relationships of tryptophan (Trp) and the metabolites of the kynurenine pathway (KP) to the occurrence of type 2 diabetes (T2D) and metabolic risk factors in obese middle-aged women.
Justyna Kubacka, Magdalena Staniszewska, Ilona Sadok, Grazyna Sypniewska, Anna Stefanska   +4 more
doaj   +1 more source

From ab initio quantum mechanics to molecular neurobiology: A cation-pi binding site in the nicotinic receptor [PDF]

, 1998
The nicotinic acetylcholine receptor is the prototype ligand-gated ion channel. A number of aromatic amino acids have been identified as contributing to the agonist binding site, suggesting that cation-pi interactions may be involved in binding the ...
Dougherty, Dennis A., Gallivan, Justin P., Lester, Henry A., Li, Lintong, Zhang, Yinong, Zhong, Wenge   +5 more
core  

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Determination and Application of Nineteen Monoamines in the Gut Microbiota Targeting Phenylalanine, Tryptophan, and Glutamic Acid Metabolic Pathways

Molecules, 2021
It has been reported that monoamine neurotransmitters can be produced by gut microbiota, and that several related metabolites of amino acids in these pathways are associated with nervous system (NVS) diseases. Herein, we focused on three pathways, namely,
Shu-Rong Ma, Jin-Bo Yu, Jie Fu, Li-Bin Pan, Hang Yu, Pei Han, Zheng-Wei Zhang, Ran Peng, Hui Xu, Yan Wang   +9 more
doaj   +1 more source

Conformational Transitions Accompanying Oligomerization of Yeast Alcohol Oxidase, a Peroxisomal Flavoenzyme [PDF]

, 1999
Alcohol oxidase (AO) is a homo-octameric flavoenzyme which catalyzes methanol oxidation in methylotrophic yeasts. AO protein is synthesized in the cytosol and subsequently sorted to peroxisomes where the active enzyme is formed.
Boteva, R, Filippi, B, van der Klei, IJ, Veenhuis, M, Visser, AJWG, Visser, Antonie J.W.G., Vriend, G   +6 more
core   +3 more sources

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source