Results 41 to 50 of about 301,590 (287)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Dip2a regulates stress susceptibility in the basolateral amygdala
Neural Regeneration ResearchDysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters.
Jing Li +6 more
doaj +1 more source
The Kynurenine Pathway in Obese Middle-Aged Women with Normoglycemia and Type 2 Diabetes
Metabolites, 2022 We examined the relationships of tryptophan (Trp) and the metabolites of the kynurenine pathway (KP) to the occurrence of type 2 diabetes (T2D) and metabolic risk factors in obese middle-aged women.
Justyna Kubacka +4 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Aquaculture NutritionTryptophan, recognized as the third limiting amino acid, plays a crucial physiological function. The optimal tryptophan requirement for oriental river prawn (Macrobrachium nipponense) was assessed, and its impact on agonistic behavior was evaluated in ...
Shiqian Cao +5 more
doaj +1 more source
In adult dogs is supplementary tryptophan in the diet effective in reducing signs of anxiety?
Veterinary EvidenceQuestion In adult dogs, is dietary supplementation with tryptophan compared with no dietary tryptophan supplement effective in reducing signs of anxiety? Clinical bottom line The category of research question was: Treatment.
Lesca Sofyan
doaj +1 more source
Molecules, 2021 It has been reported that monoamine neurotransmitters can be produced by gut microbiota, and that several related metabolites of amino acids in these pathways are associated with nervous system (NVS) diseases. Herein, we focused on three pathways, namely,
Shu-Rong Ma +9 more
doaj +1 more source
Tryptophan Catabolites and Migraine [PDF]
Current Pharmaceutical Design, 2016 Migraine is a highly disabling neurological condition affecting around 15% of the population worldwide. Decades of intensive research shed some light on diseases pathomechanism, but information is still missing about the initiation of the attack. In the past century, serotonin emerged as the main target of both basic and therapeutic research.
Bohár Zsuzsanna +2 more
openaire +3 more sources
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Tryptophan transport in human fibroblast cells : a functional characterization
, 2011 There are indications that serotonergic neurotransmission is disturbed in several psychiatric disorders. One explanation may be disturbed transport of tryptophan (precursor for serotonin synthesis) across cell membranes.
Lewander, Tommy +11 more
core +1 more source