Results 21 to 30 of about 301,590 (287)

Enteric ChAT-Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease. [PDF]

Adv Sci (Weinh)
In colitis patients and mice, reduced Lactobacillus abundance is observed. Experimental studies show that L. plantarum A736 metabolizes dietary tryptophan into indole‐3‐lactic acid (ILA), while both L. plantarum A736 and ILA impact ChAT‐expressing enteric neurons and acetylcholine levels, thereby regulating intestinal immune responses and alleviating ...
Xia B, Sun Y, Wang J, Liu Y, Wang L, Jiang S, Bai G, Zhang R, Zhang Y, Kou R, Wang D, Zhao B, Yi J, Fu Y, Liu X, Liu X.   +15 more
europepmc   +2 more sources

Biological and Clinical Factors Contributing to the Metabolic Heterogeneity of Hospitalized Patients with and without COVID-19

Cells, 2021
The Corona Virus Disease 2019 (COVID-19) pandemic represents an ongoing worldwide challenge. The present large study sought to understand independent and overlapping metabolic features of samples from acutely ill patients (n = 831) that tested positive ...
Angelo D’Alessandro, Tiffany Thomas, Imo J. Akpan, Julie A. Reisz, Francesca I. Cendali, Fabia Gamboni, Travis Nemkov, Kiruphagaran Thangaraju, Upendra Katneni, Kenichi Tanaka, Stacie Kahn, Alexander Z. Wei, Jacob E. Valk, Krystalyn E. Hudson, David Roh, Chiara Moriconi, James C. Zimring, Eldad A. Hod, Steven L. Spitalnik, Paul W. Buehler, Richard O. Francis   +20 more
doaj   +1 more source

Altered Tryptophan Catabolism in Placentas From Women With Pre-eclampsia

, 2019
Background: The kynurenine pathway enzymes, breaking down tryptophan, are abundant in placental tissue. These metabolites are involved in immunoregulatory mechanisms, although the role of this pathway in pre-eclampsia (PE) has only begun to be ...
Sarah A Keaton, Patrick Heilman, Grit, Jamie, Karen Racicot, Maya Jälmby, Zachary Madaj, Jälmby, Maya, Asgerally Fazleabas, Miller, Emily S., Brundin, Lena, Keaton, Sarah A., Racicot, Karen, Madaj, Zachary, Emily S Miller, Stefan R Hansson, Grigoros Kalapotharakos, Fazleabas, Asgerally, Kalapotharakos, Grigoros, Lena Brundin, Hansson, Stefan R., Stanislaw Krzyzanowski, Bryleva, Elena Y., Jamie Grit, Elena Y Bryleva, Heilman, Patrick, Krzyzanowski, Stanislaw, Hansson, Stefan R.,, Brundin, Lena,, Grit, Jamie,, Jälmby, Maya,, Madaj, Zachary,, Fazleabas, Asgerally,, Keaton, Sarah A.,, Racicot, Karen,, Heilman, Patrick,, Krzyzanowski, Stanislaw,, Lund University., Miller, Emily S.,, Bryleva, Elena Y.,   +38 more
core   +1 more source

Haemophilus influenzae tryptophan biosynthesis is required for lung infection

Frontiers in Cellular and Infection Microbiology
BackgroundTryptophan plays a key role in regulating human lung homeostasis and immunity through the indoleamine 2,3-dioxygenase (IDO) and aryl hydrocarbon receptor (AhR) signalling pathways.
Javier Asensio-López, Javier Asensio-López, Javier Asensio-López, Beatriz Rapún-Araiz, Beatriz Rapún-Araiz, Begoña Euba, Begoña Euba, Asier Domínguez-San Pedro, Álvaro Sanmartín, Celia Gil-Campillo, Celia Gil-Campillo, David San León, David San León, Pablo Chacón, Goizeder Almagro, Ana Ardá, Saioa Burgui, Iñigo Lasa, Alejandro Toledo-Arana, Junkal Garmendia, Junkal Garmendia, Junkal Garmendia   +21 more
doaj   +1 more source

Effect of Probiotic Administration on Serum Tryptophan Metabolites in Pediatric Type 1 Diabetes Patients [PDF]

, 2020
Type 1 diabetes (T1D) is characterized by anomalous functioning of the immuno regulatory, tryptophan-catabolic enzyme indoleamine 2,3 dioxygenase 1 (IDO1).
Volpi C., Panfili E., Orabona C., Pallotta M. T., Moretti S., Mondanelli G., Galarini R., Esposito S., Orecchini E., Belladonna M. L., Giada Mondanelli, Simone Moretti, Maria Laura Belladonna, Ciriana Orabona, Susanna Esposito, Elena Orecchini, Eleonora Panfili, Claudia Volpi, Roberta Galarini, Maria Teresa Pallotta   +19 more
core   +1 more source

Transport of tryptophan dipeptide derivatives and impact on inflammatory cytokines in monocyte/macrophage-like cells

Heliyon
Background: Tryptophan is an essential amino acid with anti-inflammatory and immunomodulatory effects. However, the absorption of amino acids including tryptophan is relatively slower than the absorption of dipeptides. Therefore, we have two aims in this
Jae B. Park, Renee Peters
doaj   +1 more source

An investigation into the temporal reproducibility of Tryptophan metabolite networks among healthy adolescents [PDF]

, 2021
Tryptophan and its bioactive metabolites are associated with health conditions such as systemic inflammation, cardiometabolic diseases, and neurodegenerative disorders. There are dynamic interactions among metabolites of tryptophan.
Nöthlings, Ute, Clarke, Gerard, Oluwagbemigun, Kolade, Mattivi, Fulvio, Schmid, Matthias, Anesi, Andrea, Kolade Oluwagbemigun, Fulvio Mattivi, Gerard Clarke, Ute Nöthlings, Matthias Schmid, Andrea Anesi   +11 more
core   +1 more source

L-Tryptophan Stimulates Bioactive Metabolite Accumulation and Cell Wall Remodelling in Flax Callus Cultures

Molecules
While L-tryptophan is a precursor of plant growth regulators, its effects on secondary metabolism, amino acid profile and cell wall organization in flax callus remain underexplored.
Kornelia L. Tudruj, Michał Piegza, Lucyna Dymińska, Maja Słupczyńska, Magdalena Wróbel-Kwiatkowska   +4 more
doaj   +1 more source

Tryptophan depletion increases nausea, headache and photophobia in migraine sufferers [PDF]

, 2006
Sensitivity to light was investigated 5 and 8 h after consumption of an amino acid drink which contained L-tryptophan (balanced amino acid condition: 19 controls and 22 migraine sufferers) or which produced a short-term reduction in brain serotonin ...
Drummond, P.D.
core  

The Tryptophan and Kynurenine Pathway Involved in the Development of Immune-Related Diseases

, 2023
The tryptophan and kynurenine pathway is well-known to play an important role in nervous, endocrine, and immune systems, as well as in the development of inflammatory diseases.
Asai Tomoko, 1000050242110, Matsuda Satoru, つじ あい, 辻 愛, Tsuji Ai, 松田 覚, Sawamura Haruka, Yoshikawa Sayuri, Ikeda Yuka, まつだ さとる, Taniguchi Kurumi, Nakashima Moeka, Morikawa Sae   +13 more
core   +1 more source