Results 11 to 20 of about 301,590 (287)

Tryptophan research in panic disorder. [PDF]

, 2008
09.02.15 KB. Ok to add published version to spiral, OA paperA considerable body of evidence suggests the involvement of serotonin neurotransmission in the pathogenesis of panic disorder.
Shlik, J, Maron, E, Nutt, DJ
core   +7 more sources

Validation of a model of regulation in the tryptophan operon against multiple experiment data using global optimisation [PDF]

, 2009
This paper is concerned with validating a mathematical model of regulation in the tryptophan operon using global optimization. Although a number of models for this biochemical network are proposed, in many cases only qualitative agreement between the ...
Postlethwaite, I., Kim, J.-R., Kim, J.-S., Heslop-Harrison, P., Bates, D.G.   +4 more
core   +7 more sources

Highly-Time-Resolved Measurements of Tryptophan's Distribution and Homeostatic Regulation in Live, Intact Animals. [PDF]

Adv Sci (Weinh)
Using a novel, aptamer‐based biosensor, here we have performed 20‐s‐resolved, in situ measurements of plasma‐free tryptophan in the jugular veins of live rats (blue). This unprecedented time‐resolution provides insights into the regulation of tryptophan metabolism in live, intact animals.
Wu Y, Brown CN, Duman Z, Bakestani RM, Kirkpatrick CM, Hespanha J, Kippin T, Plaxco KW.   +7 more
europepmc   +2 more sources

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism-Like Behavioral and Synaptic Deficits. [PDF]

Adv Sci (Weinh)
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Guo R, He C, Xiao X, Li J, Zhang Z, He Y, Wang C, Zhao J, Gong J, Liang J, Yuan T, Sun H, Liu X, Gao C, Liu Z.   +14 more
europepmc   +2 more sources

Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

Nature, 2022
Abstract Activated T cells secrete interferon-γ, which triggers intracellular tryptophan shortage by upregulating the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme 1–4 . Here we show that despite tryptophan depletion, in-frame protein synthesis continues across tryptophan ...
Abhijeet Pataskar, Julien Champagne, Remco Nagel, Juliana Kenski, Maarja Laos, Justine Michaux, Hui Song Pak, Onno B. Bleijerveld, Kelly Mordente, Jasmine Montenegro Navarro, Naomi Blommaert, Morten M. Nielsen, Domenica Lovecchio, Everett Stone, George Georgiou, Mark C. de Gooijer, Olaf van Tellingen, Maarten Altelaar, Robbie P. Joosten, Anastassis Perrakis, Johanna Olweus, Michal Bassani-Sternberg, Daniel S. Peeper, Reuven Agami   +23 more
openaire   +9 more sources

Tryptophan-Centric Bioinformatics Identifies New Lasso Peptide Modifications

Lasso peptides are a class of ribosomally synthesized and post-translationally modified peptides (RiPPs) defined by a macrolactam linkage between the N-terminus and the side chain of an internal aspartic acid or glutamic acid residue. Instead of adopting
Douglas A. Mitchell (1314975), Xiaorui Guo (4605088), Lonnie A. Harris (9702704), Hamada Saad (18177398), Lingyang Zhu (1312269), Kyle E. Shelton (18177401)   +5 more
core   +5 more sources

Interactions of Tryptophan, Tryptophan Peptides, and Tryptophan Alkyl Esters at Curved Membrane Interfaces [PDF]

Biochemistry, 2006
Motivated by ongoing efforts to understand the mechanism of membrane protein crystallogenesis and transport in the lipidic cubic phase, the nature of the interaction between tryptophan and the bilayer/aqueous interface of the cubic phase has been investigated.
Wei, Liu, Martin, Caffrey
openaire   +3 more sources

Serotonin and social norms : tryptophan depletion impairs social comparison and leads to resource depletion in a multiplayer harvesting game [PDF]

, 2014
How do people sustain resources for the benefit of individuals and communities and avoid the tragedy of the commons, in which shared resources become exhausted?
Rogers, Robert D., Cowen, P. J., Behrens, Timothy E. J., Cowen, P.J., Bilderbeck, A.C., Bilderbeck, Amy C., Brown, G.D., Behrens, T.E., Woolrich, Mark W., Woolrich, M., Read, Judi, Brown, G. D. A. (Gordon D. A.), Rogers, R., Read, J.   +13 more
core   +1 more source

Tryptophan Modulatory Role in European Seabass (Dicentrarchus labrax) Immune Response to Acute Inflammation under Stressful Conditions [PDF]

, 2022
The present work aimed to study the role of dietary tryptophan supplementation in modulating the European seabass (Dicentrarchus labrax) immune condition during stressful rearing conditions (i.e., 15 days exposure to high density), as well as the immune ...
Paulo Santos, Marina Machado, Aragão, Cláudia, Carvalho, Inês, Diogo Peixoto, Azeredo, Rita, Raquel Cêa de Aragão Teixeira, Cláudia, Machado, Marina, Inês Duarte, Duarte, Inês, Inês Carvalho, Cláudia Aragão, Peixoto, Diogo, Rita Azeredo, Benjamín Costas, Santos, Paulo, Costas, Benjamín, Ricardo, Ana, Ana Ricardo   +18 more
core   +1 more source

Tryptophan to Tryptophan Hole Hopping in an Azurin Construct

The Journal of Physical Chemistry B, 2023
Electron transfer (ET) between neutral and cationic tryptophan residues in the azurin construct [ReI(H126)(CO)3(dmp)](W124)(W122)CuI (dmp = 4,7-Me2-1,10-phenanthroline) was investigated by Born-Oppenheimer quantum-mechanics/molecular mechanics/molecular dynamics (QM/MM/MD) simulations.
Martin Melčák, Filip Šebesta, Jan Heyda, Harry B. Gray, Stanislav Záliš, Antonín Vlček   +5 more
openaire   +5 more sources