Results 11 to 20 of about 226,401 (254)

Tryptophan and depression

The Lancet, 1997
Correspondence
BARBUI, Corrado, Garattini S.
openaire   +1 more source

Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

Nature, 2022
Abstract Activated T cells secrete interferon-γ, which triggers intracellular tryptophan shortage by upregulating the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme 1–4 . Here we show that despite tryptophan depletion, in-frame protein synthesis continues across tryptophan ...
Abhijeet Pataskar, Julien Champagne, Remco Nagel, Juliana Kenski, Maarja Laos, Justine Michaux, Hui Song Pak, Onno B. Bleijerveld, Kelly Mordente, Jasmine Montenegro Navarro, Naomi Blommaert, Morten M. Nielsen, Domenica Lovecchio, Everett Stone, George Georgiou, Mark C. de Gooijer, Olaf van Tellingen, Maarten Altelaar, Robbie P. Joosten, Anastassis Perrakis, Johanna Olweus, Michal Bassani-Sternberg, Daniel S. Peeper, Reuven Agami   +23 more
openaire   +8 more sources

Interactions of Tryptophan, Tryptophan Peptides, and Tryptophan Alkyl Esters at Curved Membrane Interfaces [PDF]

Biochemistry, 2006
Motivated by ongoing efforts to understand the mechanism of membrane protein crystallogenesis and transport in the lipidic cubic phase, the nature of the interaction between tryptophan and the bilayer/aqueous interface of the cubic phase has been investigated.
Wei, Liu, Martin, Caffrey
openaire   +3 more sources

Tryptophan to Tryptophan Hole Hopping in an Azurin Construct

The Journal of Physical Chemistry B, 2023
Electron transfer (ET) between neutral and cationic tryptophan residues in the azurin construct [ReI(H126)(CO)3(dmp)](W124)(W122)CuI (dmp = 4,7-Me2-1,10-phenanthroline) was investigated by Born-Oppenheimer quantum-mechanics/molecular mechanics/molecular dynamics (QM/MM/MD) simulations.
Martin Melčák, Filip Šebesta, Jan Heyda, Harry B. Gray, Stanislav Záliš, Antonín Vlček   +5 more
openaire   +5 more sources

Nanosensor detection of an immunoregulatory tryptophan influx/kynurenine efflux cycle.

PLoS Biology, 2007
Mammalian cells rely on cellular uptake of the essential amino acid tryptophan. Tryptophan sequestration by up-regulation of the key enzyme for tryptophan degradation, indoleamine 2,3-dioxygenase (IDO), e.g., in cancer and inflammation, is thought to ...
Thijs Kaper, Loren L Looger, Hitomi Takanaga, Michael Platten, Lawrence Steinman, Wolf B Frommer   +5 more
doaj   +1 more source

Ginsenoside Rg1 Alleviates Acute Ulcerative Colitis by Modulating Gut Microbiota and Microbial Tryptophan Metabolism

Frontiers in Immunology, 2022
Ulcerative colitis (UC) is a chronic and recurrent inflammatory disorder in the gastrointestinal tract. Here, we examined the pharmacological effects of ginsenoside Rg1, a natural compound with low bioavailability, on the acute experimental colitis mice ...
Hao Cheng, Juan Liu, Dandan Zhang, Jing Wang, Yuzhu Tan, Yuzhu Tan, Wuwen Feng, Wuwen Feng, Cheng Peng, Cheng Peng   +9 more
doaj   +1 more source

Effects of Dietary Supplementation of Acetate and L-Tryptophan Conjugated Bypass Amino Acid on Productivity of Pre- and Post-Partum Dairy Cows and Their Offspring

Animals, 2021
In this study, we investigated the effect of dietary supplementation with acetate and L-tryptophan-conjugated bypass amino acid (ACT) during late pregnancy on the production performance of cows pre- and postpartum and their offspring.
Jang-Hoon Jo, Jae-Sung Lee, Jalil Ghassemi Nejad, Won-Seob Kim, Jun-Ok Moon, Hong-Gu Lee   +5 more
doaj   +1 more source

Haemophilus influenzae tryptophan biosynthesis is required for lung infection

Frontiers in Cellular and Infection Microbiology
BackgroundTryptophan plays a key role in regulating human lung homeostasis and immunity through the indoleamine 2,3-dioxygenase (IDO) and aryl hydrocarbon receptor (AhR) signalling pathways.
Javier Asensio-López, Javier Asensio-López, Javier Asensio-López, Beatriz Rapún-Araiz, Beatriz Rapún-Araiz, Begoña Euba, Begoña Euba, Asier Domínguez-San Pedro, Álvaro Sanmartín, Celia Gil-Campillo, Celia Gil-Campillo, David San León, David San León, Pablo Chacón, Goizeder Almagro, Ana Ardá, Saioa Burgui, Iñigo Lasa, Alejandro Toledo-Arana, Junkal Garmendia, Junkal Garmendia, Junkal Garmendia   +21 more
doaj   +1 more source

Biological and Clinical Factors Contributing to the Metabolic Heterogeneity of Hospitalized Patients with and without COVID-19

Cells, 2021
The Corona Virus Disease 2019 (COVID-19) pandemic represents an ongoing worldwide challenge. The present large study sought to understand independent and overlapping metabolic features of samples from acutely ill patients (n = 831) that tested positive ...
Angelo D’Alessandro, Tiffany Thomas, Imo J. Akpan, Julie A. Reisz, Francesca I. Cendali, Fabia Gamboni, Travis Nemkov, Kiruphagaran Thangaraju, Upendra Katneni, Kenichi Tanaka, Stacie Kahn, Alexander Z. Wei, Jacob E. Valk, Krystalyn E. Hudson, David Roh, Chiara Moriconi, James C. Zimring, Eldad A. Hod, Steven L. Spitalnik, Paul W. Buehler, Richard O. Francis   +20 more
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Transport of tryptophan dipeptide derivatives and impact on inflammatory cytokines in monocyte/macrophage-like cells

Heliyon
Background: Tryptophan is an essential amino acid with anti-inflammatory and immunomodulatory effects. However, the absorption of amino acids including tryptophan is relatively slower than the absorption of dipeptides. Therefore, we have two aims in this
Jae B. Park, Renee Peters
doaj   +1 more source