Modulation of tryptophan/serotonin pathway by probiotic supplementation in human immunodeficiency virus-positive patients: preliminary results of a new study approach [PDF]
, 2017 Background: To date, no data are available regarding the effects of probiotics on the pathway of tryptophan/serotonin metabolism among human immunodeficiency virus (HIV) 1–infected individuals.
Cavallari, Eugenio Nelson +14 more
core +3 more sources
Memory Enhancement with Kynurenic Acid and Its Mechanisms in Neurotransmission
Biomedicines, 2022 Kynurenic acid (KYNA) is an endogenous tryptophan (Trp) metabolite known to possess neuroprotective property. KYNA plays critical roles in nociception, neurodegeneration, and neuroinflammation.
Diána Martos +4 more
doaj +1 more source
Tryptophan-Tryptophan energy migration as a tool to follow apoflavodoxin folding [PDF]
, 2008 Submolecular details of Azotobacter vinelandii apoflavodoxin (apoFD) (un)folding are revealed by time-resolved fluorescence anisotropy using wild-type protein and variants lacking one or two of apoFD's three tryptophans.
Visser, N.V. +5 more
core +1 more source
Novel African trypanocidal agents: membrane rigidifying peptides [PDF]
, 2012 The bloodstream developmental forms of pathogenic African trypanosomes are uniquely susceptible to killing by small hydrophobic peptides. Trypanocidal activity is conferred by peptide hydrophobicity and charge distribution and results from increased ...
Andreas Hartel +8 more
core +7 more sources
Microbial Cell Factories, 2012 Background L-tryptophan is an aromatic amino acid widely used in the food, chemical and pharmaceutical industries. In Escherichia coli, L-tryptophan is synthesized from phosphoenolpyruvate and erythrose 4-phosphate by enzymes in the shikimate pathway and
Gu Pengfei +4 more
doaj +1 more source
Toward an Alternative Intrinsic Probe for Spectroscopic Characterization of a Protein [PDF]
, 2010 The intrinsic fluorescent amino acid tryptophan is the unanimous choice for the spectroscopic investigation of proteins. However, several complicacies in the interpretation of tryptophan fluorescence in a protein are inevitable and an alternative ...
Goswami, Nirmal +2 more
core +1 more source
Nanosensor detection of an immunoregulatory tryptophan influx/kynurenine efflux cycle.
PLoS Biology, 2007 Mammalian cells rely on cellular uptake of the essential amino acid tryptophan. Tryptophan sequestration by up-regulation of the key enzyme for tryptophan degradation, indoleamine 2,3-dioxygenase (IDO), e.g., in cancer and inflammation, is thought to ...
Thijs Kaper +5 more
doaj +1 more source
Properties of the mechanosensitive channel MscS pore revealed by tryptophan scanning mutagenesis [PDF]
, 2015 Funding This work was supported by a Wellcome Trust Programme grant [092552/A/10/Z awarded to I.R.B., S.M., J. H. Naismith (University of St Andrews, St Andrews, U.K.), and S. J. Conway (University of Oxford, Oxford, U.K.)] (T.R.
Akiko Rasmussen +12 more
core +4 more sources
Proton transfer in histidine-tryptophan heterodimers embedded in helium droplets
, 2015 We used cold helium droplets as nano-scale reactors to form and ionize, by electron bombardment and charge transfer, aromatic amino acid heterodimers of histidine with tryptophan, methyl-tryptophan, and indole. The molecular interaction occurring through
Bellina, Bruno +2 more
core +1 more source
Frontiers in Immunology, 2022 Ulcerative colitis (UC) is a chronic and recurrent inflammatory disorder in the gastrointestinal tract. Here, we examined the pharmacological effects of ginsenoside Rg1, a natural compound with low bioavailability, on the acute experimental colitis mice ...
Hao Cheng +9 more
doaj +1 more source