Results 101 to 110 of about 270,080 (298)

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Aromatic residue Trp146 mediates dynamic interplay between type IVa pili and exopolysaccharide in social motility of Myxococcus xanthus

mBio
The social motility (S-motility) of Myxococcus xanthus is driven by the intricate interplay between type IVa pili (T4aP) and exopolysaccharide (EPS). Although T4aP retraction furnishes the mechanical force necessary for cellular movement, EPS serves as a
Yan Wang, Yipeng Wang, Weiwei Xue, Jiaxin Li, Fujian Zhang, Xiashi Lv, Fengyu Zhang, Yuezhong Li, Chuandong Wang, Wei Hu   +9 more
doaj   +1 more source

Phenylalanine and Tryptophan Intake of Hyperactive Children with Autism

Journal of Biomedicine and Translational Research, 2017
Background: Hyperactive is behavior which demonstrates the attitude of more energy than normal behavior. Level of neurotransmitter dopamine and serotonin in the body may be the factor of this disorder behavior.
Puspito Arum, Dahlia Indah Amareta, Faridlotul Zannah   +2 more
doaj   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Sequence Permutation Generated Lysine and Tryptophan-Rich Antimicrobial Peptides with Enhanced Therapeutic Index

Antibiotics
Background/Objectives: Antimicrobial peptides (AMPs) are promising therapeutic agents due to their broad-spectrum activity against bacteria, viruses, and fungi.
Kuang-Li Peng, Yu-Hsuan Wu, Hsuan-Che Hsu, Jya-Wei Cheng   +3 more
doaj   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites

, 2016
Metabolites of the kynurenine pathway (KP) of tryptophan (TRP) degradation have been closely linked to the pathogenesis of several neurodegenerative disorders.
Jasper G. Estranero (7640102), Flaviano Giorgini (58325), Francesca M. Notarangelo (7666691), Gareth G. L. Moore (7666694), Charalambos P. Kyriacou (7033136), Carlo Breda (5076125), Korrapati V. Sathyasaikumar (2276320), Robert Schwarcz (1870747), Shama Sograte Idrissi (7666688), Edward W. Green (7666697)   +9 more
core   +1 more source

The gut microbiota and its metabolites: novel therapeutic targets for inflammatory bowel disease

Frontiers in Immunology
Inflammatory bowel disease (IBD) pathogenesis is critically influenced by gut microbiota dysbiosis and perturbations in associated metabolites. This review outlines current IBD diagnostic and therapeutic paradigms, highlighting the persistent focus on ...
Xingyu Shen, Xingyu Shen, Yue Li, Yue Li, Deqiang Wang, Kang Sun   +5 more
doaj   +1 more source

Lysine-Tryptophan-Crosslinked Peptides Produced by Radical SAM Enzymes in Pathogenic Streptococci

, 2017
Macrocycles represent a common structural framework in many naturally occurring peptides. Several strategies exist for macrocyclization, and the enzymes that incorporate them are of great interest, as they enhance our repertoire for creating complex ...
Mohammad R. Seyedsayamdost (129142), Kelsey R. Schramma (3811825)   +1 more
core   +1 more source

Tryptophan Metabolism and Its Relationship with Depression and Cognitive Impairment Among HIV-infected Individuals [PDF]

, 2016
Objective: Cognitive impairment (CI) and major depressive disorder (MDD) remain prevalent in treated HIV-1 disease; however, the pathogenesis remains elusive.
Chittiprol, S, Winston, A, Adriano Boasso, Keegan, MR, Scott L. Letendre, Alan Winston, Iudicello, J, Ronald J. Ellis, Seetharamaiah Chittiprol, Fuchs, D, Jennifer Iudicello, Boasso, A, Letendre, SL, Ellis, RJ, Michael R. Keegan, Dietmar Fuchs   +15 more
core   +1 more source