Results 111 to 120 of about 301,590 (287)

Dietary tryptophan intervention counteracts stress-induced transcriptional changes in a teleost fish HPI axis during inflammation

Immune nutrition is currently used to enhance fish health by incorporating functional ingredients into aquafeeds. This study aimed to investigate the connections between tryptophan nutrition and the network that regulates the communication pathways ...
Peixoto, Diogo, Aragão, Cláudia, Carvalho, Inês, Azeredo, Rita, Machado, Marina, Costas, Benjamín   +5 more
core   +1 more source

An Effector TaCRVP From Tuta Absoluta Oral Secretion Impairs H2O2‐Mediated Plant Defense by Targeting Tomato SlCAT2

Advanced Science, EarlyView.
The Tuta absoluta salivary effector TaCRVP subverts tomato immunity by hijacking host catalase SlCAT2. Through a sophisticated dual mechanism, TaCRVP simultaneously promotes SlCAT2 tetramerization for activation and blocks its SlAdBiL‐mediated degradation for stabilization.
Jianquan Yan, Youdan Zhang, Zhujun Wang, Huatao Tang, Huiping Liu, Zi Chen, Shuai Liu, Jiayi Shi, Lu Peng, Youming Hou   +9 more
wiley   +1 more source

Association of tryptophan pathway metabolites with mortality and effectiveness of nutritional support among patients at nutritional risk: secondary analysis of a randomized clinical trial

Frontiers in Nutrition
Tryptophan is an essential amino acid and is the precursor of many important metabolites and neurotransmitters. In malnutrition, the availability of tryptophan is reduced, potentially putting patients at increased risks.
Jacqueline Ritz, Jacqueline Ritz, Carla Wunderle, Franziska Stumpf, Rahel Laager, Rahel Laager, Pascal Tribolet, Pascal Tribolet, Pascal Tribolet, Peter Neyer, Luca Bernasconi, Zeno Stanga, Beat Mueller, Beat Mueller, Philipp Schuetz, Philipp Schuetz   +15 more
doaj   +1 more source

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites

, 2016
Metabolites of the kynurenine pathway (KP) of tryptophan (TRP) degradation have been closely linked to the pathogenesis of several neurodegenerative disorders.
Jasper G. Estranero (7640102), Flaviano Giorgini (58325), Francesca M. Notarangelo (7666691), Gareth G. L. Moore (7666694), Charalambos P. Kyriacou (7033136), Carlo Breda (5076125), Korrapati V. Sathyasaikumar (2276320), Robert Schwarcz (1870747), Shama Sograte Idrissi (7666688), Edward W. Green (7666697)   +9 more
core   +2 more sources

Metabolism of tryptophan along the kynurenine pathway in alloxan diabetic rabbits

, 2002
In vivo study of the metabolism of tryptophan along the kynurenine pathway in alloxan diabetic ...
ALLEGRI, GRAZIELLA, Guglielmina Froldi, COSTA, CARLO VIRGILIO LUIGI, G. ALLEGRI, Eugenio Ragazzi, Delia Zaccarin, FROLDI, GUGLIELMINA, C.V.L. COSTA, BERTAZZO, ANTONELLA, Carlo V.L. Costa, D. ZACCARIN, ZACCARIN D, RAGAZZI, EUGENIO, Graziella Allegri, Antonella Bertazzo, A. BERTAZZO   +15 more
core   +1 more source

Carbohydrate‐Mediated Cellular Uptake of Boronic Acid Hybrids In Cellulo and Insulin‐Deficient Zebrafish: Live Imaging and Application of Multiphoton FLIM

Advanced Science, EarlyView.
Boronic acid‐based fluorescent hybrids have been used as part of a versatile platform for real‐time metabolic bioimaging across cellular and organismal scales. Including glucose‐responsive imaging in living cells and in an insulin‐deficient vertebrate model, this work opens new opportunities for the development of precision diagnostics, metabolic ...
Haobo Ge, John S. Fossey, David Gonzalez Calatayud, Stephen E. Flower, Sabrina Wang, Hanna Aitessaid, Melita Tvardauskaite, Julia Dudzic, Max Jewell, Charareh Pourzand, Stanley W. Botchway, David Gurevich, Tony D. James, Sofia I. Pascu   +13 more
wiley   +1 more source

ON THE EMISSION OF TRYPTOPHAN [PDF]

Proceedings of the National Academy of Sciences, 1958
I, Isenberg, A, Szent-Györgyi
openaire   +2 more sources

Intestinal transport of tryptophan and its analogs

, 1975
A comparative study of the intestinal transport of DL-tryptophan and its 1-methylindole (tryptophan-l-Me) and benzo[b]thiophene (tryptophan-S) analogs has been carried out in vitro, using the everted intestinal sac of the rat and hamster.
DR Hathaway, RP Maickel, TR Bosin
core   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source