Results 121 to 130 of about 306,090 (270)

The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders [PDF]

, 2013
Understanding the neurochemical basis for cognitive function is one of the major goals of neuroscience, with a potential impact on the diagnosis, prevention and treatment of a range of psychiatric and neurological disorders.
Akagbosu, Akladios, Alexander, Alkondon, Alkondon, Alkondon, Amori, Andersen, Atlas, Autier, Backman, Beal, Benatti, Bonda, Breese, Carpenedo, Carpenedo, Casazza, Castellano, Ceresoli-Borroni, Cesura, Chess, Chess, Chess, Chiarugi, Chiarugi, Clark, Cochran, Cozzi, Cui, Daily, Dalley, Dantzer, Darlington, Darlington, Davidson, Deiana, Della Torre, DiNatale, Dobelis, Dounay, Eastman, Erhardt, Forrest, Forrest, Forrest, Forrest, Fukui, Gellert, Giordani, Giorgini, Gold, Graef, Guidetti, Guidetti, Guidetti, Guidetti, Guillemin, Guillemin, Hardingham, Hedges, Henderson, Heng, Hernandez, Heyes, Hilmas, Holtze, Jason, Jauch, Jentsch, Jurgens, Kalisch, Kandanearatchi, Kiank, Kihara, Kloet, Kocki, Konradsson-Geuken, Lawrence, Lawrence, Linderholm, Lindsley, Luchowski, Luchowski, Lupien, Marin, Mexal, Millan, Miller, Minzenberg, Miura, Moeller, Mok, Muchowski, Muchowski, Mueller, Muscatell, Myint, Nagy, Neill, Newcomer, Newcomer, Nilsson, Nilsson, Nozaki, O'Connor, Olsson, Onur, Owe-Young, Paterson, Pearson, Pechtel, Pellicciari, Pellicciari, Perkins, Pertovaara, Pevarello, Phillips, Pocivavsek, Pocivavsek, Popoli, Popoli, Potter, Rahman, Raison, Rassoulpour, Ren, Robert, Rodgers, Rossi, Ryu, Röver, Saito, Salazar, Sapko, Sarter, Sathyasaikumar, Sathyasaikumar, Schwarcz, Schwarcz, Schwarcz, Schwarcz, Shear, Speciale, Speciale, Stazka, Stazka, Stone, Stone, Stone, Stone, Stone, Stoy, Tadaiesky, Tatter, Teichberg, Teichberg, Ting, Trecartin, Tse, Varasi, Vezzani, Walker, Wang, Wang, Wejksza, Wejksza, Wonodi, Xu, Yamada, Yuen, Zisapel, Zmarowski   +172 more
core   +1 more source

Reimagining IDO Pathway Inhibition in Cancer Immunotherapy via Downstream Focus on the Tryptophan–Kynurenine–Aryl Hydrocarbon Axis

Clinical Cancer Research, 2018
Significant progress has been made in cancer immunotherapy with checkpoint inhibitors targeting programmed cell death protein 1 (PD-1)–programmed death-ligand 1 signaling pathways.
Brian W. Labadie, R. Bao, J. Luke
semanticscholar   +1 more source

Phenylalanine and Tryptophan Intake of Hyperactive Children with Autism

Journal of Biomedicine and Translational Research, 2017
Background: Hyperactive is behavior which demonstrates the attitude of more energy than normal behavior. Level of neurotransmitter dopamine and serotonin in the body may be the factor of this disorder behavior.
Puspito Arum, Dahlia Indah Amareta, Faridlotul Zannah   +2 more
doaj   +1 more source

Tryptophan Metabolism in Alcoholism [PDF]

Nutrition Research Reviews, 1999
Studies of tryptophan (Trp) metabolism in relation to the serotonin status in alcoholism are of 2 types: (1) those related to the pharmacological effects of ethanol; (2) those concerning the serotonin status in the absence of alcohol intake. In experimental animals, acute and chronic ethanol administration and subsequent withdrawal exert a variety of ...
openaire   +5 more sources

Ultraviolet Photostability Improvement for Autofluorescence Correlation Spectroscopy on Label-Free Proteins [PDF]

arXiv, 2020
The poor photostability and low brightness of protein autofluorescence have been major limitations preventing the detection of label-free proteins at the single molecule level. Overcoming these issues, we report here a strategy to promote the photostability of proteins and use their natural tryptophan autofluorescence in the ultraviolet (UV) for ...
arxiv  

Nicotinic α7 acetylcholine receptor-mediated currents are not modulated by the tryptophan metabolite kynurenic acid in adult hippocampal interneurons [PDF]

, 2012
The tryptophan metabolite, kynurenic acid (KYNA), is classically known to be an antagonist of ionotropic glutamate receptors. Within the last decade several reports have been published suggesting that KYNA also blocks nicotinic acetylcholine receptors (nAChRs) containing the \alpha7 subunit (\alpha7*).
arxiv   +1 more source

The therapeutic potential of targeting tryptophan catabolism in cancer

British Journal of Cancer, 2019
Based on its effects on both tumour cell intrinsic malignant properties as well as anti-tumour immune responses, tryptophan catabolism has emerged as an important metabolic regulator of cancer progression. Three enzymes, indoleamine-2,3-dioxygenase 1 and
C. Opitz, Luis F. Somarribas Patterson, S. Mohapatra, D. L. Dewi, Ahmed Sadik, M. Plattén, S. Trump   +6 more
semanticscholar   +1 more source

The Use of Dietary Additives in Fish Stress Mitigation: Comparative Endocrine and Physiological Responses [PDF]

, 2019
In the last years, studies on stress attenuation in fish have progressively grown. This is mainly due to the interest of institutions, producers, aquarists and consumers in improving the welfare of farmed fish.
Abdel-Tawwab, Alderman, Alves Martins, Alves Martins, Alves Martins, Aragão, Araújo, Azeredo, Azeredo, Babaei, Baltzegar, Basic, Basic, Belo, Benítez-Dorta, Berntssen, Berntssen, Betancor, Blazer, Brake, Bransden, Cabanillas-Gámez, Cardoso, Chen, Chen, Chen, Cheng, Conceição, Conde-Sieira, Cosgrove, Costas, Costas, Costas, Costas, Costas, Costas, Dabrowska, Dabrowski, Davis, Dhabhar, Dimitroglou, Doyon, Eissa, Fabbri, Falahatkar, Faught, Fletcher, Forsatkar, Fracalossi, Fu, Fuchs, Ganga, Ganga, Ganga, Gil, González-Silvera, Gorissen, Gorissen, Gorissen, Gorissen, Grimble, Grimble, Guimarães, Habte-Tsion, Halver, Harpaz, Herrera, Hog¨lund, Hooley, Hoseini, Hoseini, Hoseinifar, Hseu, Hwang, Höglund, Höglund, Imanpoor, Iwama, Izquierdo, Jia, Kanazawa, Kenari, Khassaf, Kiilerich, Kim, Kim, Kiron, Kitabchi, Koshio, Koven, Kumar, Kumar, Küçükbay, Lall, Lanes, Leonardi, Leong, Lepage, Lepage, Lepage, Li, Li, Li, Li, Liu, Liu, Liu, Liu, Lochmann, Long, Martin, Martins, Martins, McDowell, McKenzie, McKenzie, Mechlaoui, Melnyk-Lamont, Miao, Mommsen, Montero, Montero, Montero, Montero, Montero, Morandini, Morrow, Naderi, Nye, Olmos-Soto, Palermo, Papoutsoglou, Pardue, Pérez-Jiménez, Pérez-Sánchez, Read, Rezek, Rider, Ringø, Rønnestad, Sakai, Saleh, Sang, Schreck, Schreck, Skrzynska, Solano, Sándor, Tahmasebi-Kohyani, Tejpal, Thompson, Tian, Tocher, Torrecillas, Torrecillas, Trenzado, Trenzado, Trushenski, Van Anholt, Van Anholt, Verburg-van Kemenade, Vijayan, Wang, Watanabe, Weirich, Winberg, Wolkers, Wu, Xie, Xu, Yao, Yoshizawa, Yousefi, Zacharieva   +173 more
core   +2 more sources

L-Tryptophan Enhances Intestinal Integrity in Diquat-Challenged Piglets Associated with Improvement of Redox Status and Mitochondrial Function

Animals, 2019
Tryptophan (Trp) supplementation has been shown to improve growth performance and enhance intestinal integrity in piglets. However, the effects of dietary Trp supplementation on the intestinal barrier function in piglets exposed to oxidative stress ...
Jingbo Liu, Yong Zhang, Yan Li, Honglin Yan, Hongfu Zhang   +4 more
doaj   +1 more source

Is Amino-Acid Homochirality Due To Asymmetric Photolysis In Space? [PDF]

arXiv, 1999
Amino acids occurring in proteins are, with rare exceptions, exclusively of the L-configuration. Among the many scenarios put forward to explain the origin of this chiral homogeneity (i.e., homochirality), one involves the asymmetric photolysis of amino acids present in space, triggered by circularly polarized UV radiation.
arxiv