Results 131 to 140 of about 436,973 (328)

Chemical Approaches for Array Based Detection of Amyloids

open access: yesAdvanced Sensor Research, EarlyView.
Amyloids are protein aggregates with both pathological and functional roles. Their detection is challenged by structural polymorphism, isoform diversity, and dynamic aggregation behavior. This review presents chemical array‐based sensing strategies that address these complexities, emphasizing fluorescence and colorimetric methods, alongside ...
Paulo M. Simon, Yijia Xu, Amandeep Kaur
wiley   +1 more source

Hemp Proteins Conjugated with Green Tea Polyphenol Extract Form De Novo Plant‐Sourced Emulsifiers Suitable for Nanodelivery Systems Bearing Lipophilic Psychopharmaceuticals

open access: yesAdvanced Therapeutics, EarlyView.
Green tea polyphenols, conjugated either covalently or non‐covalently to hemp protein, comprise an excellent stabilizing matrix for oxidatively‐sensitive small molecules. These nanoemulsions are highly stable to a variety of chemical and physical stressors, protecting the small molecule while allowing for easy uptake across cell membranes and rapid ...
William Charles Hosie   +9 more
wiley   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

open access: yesAdvanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian   +26 more
wiley   +1 more source

TRYPTOPHAN METABOLISM

open access: hybrid, 1949
Charles Heidelberger   +2 more
openalex   +2 more sources

A Peripheral Mechanism of Depression: Disturbed Intestinal Epithelial Per2 Gene Expression Causes Depressive Behaviors in Mice with Circadian Rhythm Disruption via Gut Barrier Damage and Microbiota Dysbiosis

open access: yesAdvanced Science, EarlyView.
Circardian rhythm disorder (CRD) causes abnormal expression of intestinal Period 2 (Per2) gene, which compromising intestinal barrier integrity and altering the gut microenvironment. Microbiota dysbiosis and aberrant metabolites production drive central inflammation, impair neurogenesis, and promote functional deficits, ultimately facilitating the ...
Huiliang Zhang   +16 more
wiley   +1 more source

LYSINE, METHIONINE AND TRYPTOPHAN CONTENT OF MICROORGANISMS I. Bacteria [PDF]

open access: bronze, 1958
R. F. Anderson   +5 more
openalex   +1 more source

Predicting Immunotherapy Outcomes in NSCLC Using RNA and Pathology from Multicenter Clinical Trials

open access: yesAdvanced Science, EarlyView.
LIRA, a machine learning‐based model, is developed using transcriptomic data from 891 NSCLC patients in the OAK and POPLAR cohorts. Its predictive performance is validated in multiple external cohorts. Patients stratified by LIRA‐score exhibit distinct clinical characteristics and tumor microenvironment profiles.
Zhaojun Wang   +32 more
wiley   +1 more source

ON THE EMISSION OF TRYPTOPHAN [PDF]

open access: yesProceedings of the National Academy of Sciences, 1958
Irvin Isenberg, Albert Szent-Györgyi
openaire   +3 more sources

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