Results 141 to 150 of about 229,751 (309)

Engineering Decavalent, Sperm‐Binding Laminin‐IgG Hybrid Antibodies for Potent Non‐Hormonal Contraception

Advanced Science, EarlyView.
This study investigates a highly multivalent mAb platform fusing Laminin‐511 heterotrimerization domains with Fabs and IgG1‐Fc as a non‐hormonal contraceptive. The most potent molecule ‘LamH10’, possessing 10 Fabs, rapidly achieved >99% reduction in progressively motile sperm at just 33µg per dose in sheep, making the laminin‐IgG hybrid platform the ...
Alison Schaefer, Keiichiro Kushiro, Bhawana Shrestha, Yong Zhu, Alysha Panjwani, Lauren Dawson, Haley Flowers, Kathleen L. Vincent, Samuel K. Lai   +8 more
wiley   +1 more source

THE EFFECT OF ADRENALECTOMY AND OF CORTISONE ADMINISTRATION ON THE METABOLISM OF l-TRYPTOPHAN

, 1956
F. Christine Brown, Clarence P. Berg
openalex   +1 more source

The Nitrogen-Distribution in Bence-Jones' Protein, with a Note upon a New Colorimetric Method for Tryptophan-Estimation in Protein [PDF]

, 1922
Ery Lüscher
openalex   +1 more source

DL-Tryptophan Alleviates Sepsis-Related Acute Liver Injury via AhR Activation. [PDF]

J Inflamm Res
Li B, Wang Q, Hu L, Duan W, Chen Y, Wang Z, Liu C, Liao L.   +7 more
europepmc   +1 more source

Engineering Adenine Deaminase TadA for Precise and PAM‐Flexible Point Mutagenesis and Gradient‐Tuning Endogenous Protein Design

Advanced Science, EarlyView.
Base editing enables precise nucleotide substitutions but limited by bystander editing. This study engineers plant base editors by fusing optimized TadA variants with PAM‐flexible SpRY nickase, enabling A‐to‐G, C‐to‐T, and dual‐base conversions in a highly condensed window (≤3 nucleotides). Additionally, TadDBE (TadA Dual‐Base Editor)‐mediated directed
Kangli Sun, Si Cheng, Nan Chai, Jianing Mi, Ruixiang Zhang, Qian Qian, Zhiye Zheng, Ke Chen, Dongchang Zeng, Xin Peng, Mengyuan Shen, Degui Zhou, Qinlong Zhu, Qi Liu, Jiantao Tan   +14 more
wiley   +1 more source

Mechanoactivated Celite as a Catalyst for C‒H Bond Perfluoroalkylation and Other Radical Reactions

Angewandte Chemie, EarlyView.
Biogenic materials naturally containing trace metals such as Celite or diatomaceous earth promote practical perfluoroalkylation of C─H bonds of (hetero)arenes and a double bond bromination with N‐bromosuccinimide upon mechanoactivation via ball milling. This conceptually broadens the scope of mechanoactivated solids beyond piezoelectric materials. This
Thomas J. Hasiweder, Hoan M. Dinh, Dilip K. Pandey, Aleksandr Sorvanov, Julia R. Khusnutdinova   +4 more
wiley   +2 more sources

Cancer of the Urinary Bladder Induced in Mice with Metabolites of Aromatic Amines and Tryptophan

, 1957
Mark Allen, E. Boyland, C E Dukes, E. S. Horning, J.G. Watson   +4 more
openalex   +1 more source

Novel L-tryptophan-functionalized zirconium dioxide nanoparticles catalysed one-pot and solvent-free synthesis of 2 H-indazolo [2, 1-b] phthalazine-triones. [PDF]

Sci Rep
Abbas AK, Safaei-Ghomi J, Moein-Najafabadi S.   +2 more
europepmc   +1 more source

Florigen and Florigen‐Like Genes Regulate Temperature‐Responsive Flowering in Tomato

Advanced Science, EarlyView.
This study uncovers that FLOWERING LOCUS T‐Like 2 (FTL2) and SINGLE‐FLOWER TRUSS (SFT) antagonistically regulate temperature‐responsive flowering in the tomato shoot apical meristem. High temperature induces floral repressor FTL2, which directly inhibits SFT to delay short‐day floral transition, while SFT reciprocally inhibits FTL2 to promote flowering.
Jia Song, Shiqi Zhao, Siyu Fang, Xiaotian Wang, Shuai Sun, Baohua Li, Ren Li, Lu Liu, Xia Cui   +8 more
wiley   +1 more source

Regioselective Hydration of Terpenes with Cofactor‐Independent Carotenoid 1,2‐Hydratase

Angewandte Chemie, EarlyView.
This study reveals a highly regioselective and cofactor‐independent enzymatic approach to terpene and terpenoid hydration using a carotenoid 1,2‐hydratase from Rubrivivax gelatinosus. Beyond detailing reaction optimization strategies, an extensive substrate scope, and scale‐up potential, it explores mutagenesis and structural modeling to identify key ...
Philip Horz, Natalie Härterich, Andreas Schneider, Nicolas D. Travnicek, Bettina M. Nestl, Ursula Kahler, Bernhard Hauer   +6 more
wiley   +2 more sources