Results 31 to 40 of about 504,978 (306)

Clinical Persistence of Chlamydia trachomatis Sexually Transmitted Strains Involves Novel Mutations in the Functional αββα Tetramer of the Tryptophan Synthase Operon. [PDF]

, 2019
Clinical persistence of Chlamydia trachomatis (Ct) sexually transmitted infections (STIs) is a major public health concern. In vitro persistence is known to develop through interferon gamma (IFN-γ) induction of indoleamine 2,3-dioxygenase (IDO), which ...
Dean, Deborah, Ferrin, Thomas E, Hyuk Suh, Jung, Somboonna, Naraporn, Ziklo, Noa   +4 more
core   +1 more source

Microbial tryptophan catabolites in health and disease

Nature Communications, 2018
Accumulating evidence implicates metabolites produced by gut microbes as crucial mediators of diet-induced host-microbial cross-talk. Here, we review emerging data suggesting that microbial tryptophan catabolites resulting from proteolysis are ...
H. Roager, T. R. Licht
semanticscholar   +1 more source

Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies

Gut, 2021
Objective Tryptophan can be catabolised to various metabolites through host kynurenine and microbial indole pathways. We aimed to examine relationships of host and microbial tryptophan metabolites with incident type 2 diabetes (T2D), host genetics, diet ...
Q. Qi, Jun Li, B. Yu, Jee-Young Moon, J. Chai, J. Merino, Jieping Hu, M. Ruíz-Canela, C. Rebholz, Zheng Wang, Mykhaylo Usyk, Guo-Chong Chen, Bianca C. Porneala, Wenshuang Wang, N. Q. Nguyen, E. Feofanova, Megan L. Grove, Thomas J. Wang, R. Gerszten, J. Dupuis, J. Salas‐Salvadó, W. Bao, D. Perkins, M. Daviglus, B. Thyagarajan, Jianwen Cai, Tao Wang, J. Manson, M. Martínez-González, E. Selvin, K. Rexrode, C. Clish, F. Hu, J. Meigs, R. Knight, R. Burk, E. Boerwinkle, R. Kaplan   +37 more
semanticscholar   +1 more source

Effects of Dietary Supplementation of Acetate and L-Tryptophan Conjugated Bypass Amino Acid on Productivity of Pre- and Post-Partum Dairy Cows and Their Offspring

Animals, 2021
In this study, we investigated the effect of dietary supplementation with acetate and L-tryptophan-conjugated bypass amino acid (ACT) during late pregnancy on the production performance of cows pre- and postpartum and their offspring.
Jang-Hoon Jo, Jae-Sung Lee, Jalil Ghassemi Nejad, Won-Seob Kim, Jun-Ok Moon, Hong-Gu Lee   +5 more
doaj   +1 more source

Lactobacillus reuteri tryptophan metabolism promotes host susceptibility to CNS autoimmunity

Microbiome, 2022
Background Dysregulation of gut microbiota-associated tryptophan metabolism has been observed in patients with multiple sclerosis. However, defining direct mechanistic links between this apparent metabolic rewiring and individual constituents of the gut ...
T. Montgomery, Korin M. Eckstrom, Katarina H. Lile, Sydney Caldwell, E. Heney, K. Lahue, Angelo D’Alessandro, M. Wargo, D. Krementsov   +8 more
semanticscholar   +1 more source

Biological and Clinical Factors Contributing to the Metabolic Heterogeneity of Hospitalized Patients with and without COVID-19

Cells, 2021
The Corona Virus Disease 2019 (COVID-19) pandemic represents an ongoing worldwide challenge. The present large study sought to understand independent and overlapping metabolic features of samples from acutely ill patients (n = 831) that tested positive ...
Angelo D’Alessandro, Tiffany Thomas, Imo J. Akpan, Julie A. Reisz, Francesca I. Cendali, Fabia Gamboni, Travis Nemkov, Kiruphagaran Thangaraju, Upendra Katneni, Kenichi Tanaka, Stacie Kahn, Alexander Z. Wei, Jacob E. Valk, Krystalyn E. Hudson, David Roh, Chiara Moriconi, James C. Zimring, Eldad A. Hod, Steven L. Spitalnik, Paul W. Buehler, Richard O. Francis   +20 more
doaj   +1 more source

The Role of Tryptophan Dysmetabolism and Quinolinic Acid in Depressive and Neurodegenerative Diseases

Biomolecules, 2022
Emerging evidence suggests that neuroinflammation is involved in both depression and neurodegenerative diseases. The kynurenine pathway, generating metabolites which may play a role in pathogenesis, is one of several competing pathways of tryptophan ...
K. Hestad, J. Alexander, H. Rootwelt, J. Aaseth   +3 more
semanticscholar   +1 more source

The Role of Tryptophan Metabolites in Neuropsychiatric Disorders

International Journal of Molecular Sciences, 2022
In recent decades, neuropsychiatric disorders such as major depressive disorder, schizophrenia, bipolar, etc., have become a global health concern, causing various detrimental influences on patients.
Majid Davidson, Niloufar Rashidi, K. Nurgali, V. Apostolopoulos   +3 more
semanticscholar   +1 more source

Toward an Alternative Intrinsic Probe for Spectroscopic Characterization of a Protein [PDF]

, 2010
The intrinsic fluorescent amino acid tryptophan is the unanimous choice for the spectroscopic investigation of proteins. However, several complicacies in the interpretation of tryptophan fluorescence in a protein are inevitable and an alternative ...
Goswami, Nirmal, Makhal, Abhinandan, Pal, Samir Kumar   +2 more
core   +1 more source

One-step of tryptophan attenuator inactivation and promoter swapping to improve the production of L-tryptophan in Escherichia coli

Microbial Cell Factories, 2012
Background L-tryptophan is an aromatic amino acid widely used in the food, chemical and pharmaceutical industries. In Escherichia coli, L-tryptophan is synthesized from phosphoenolpyruvate and erythrose 4-phosphate by enzymes in the shikimate pathway and
Gu Pengfei, Yang Fan, Kang Junhua, Wang Qian, Qi Qingsheng   +4 more
doaj   +1 more source