Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer. [PDF]
, 2016 Renal cell carcinoma (RCC) is increasing in incidence, and a complete cure remains elusive. While immune-checkpoint antibodies are promising, interferon-based immunotherapy has been disappointing.
Abu Aboud, Omran +13 more
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A comprehensive analysis of the importance of translation initiation factors for Haloferax volcanii applying deletion and conditional depletion mutants [PDF]
, 2013 Translation is an important step in gene expression. The initiation of translation is phylogenetically diverse, since currently five different initiation mechanisms are known.
Gäbel, Katrin +4 more
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Proton transfer in histidine-tryptophan heterodimers embedded in helium droplets
, 2015 We used cold helium droplets as nano-scale reactors to form and ionize, by electron bombardment and charge transfer, aromatic amino acid heterodimers of histidine with tryptophan, methyl-tryptophan, and indole. The molecular interaction occurring through
Bellina, Bruno +2 more
core +1 more source
Biotechnology & Biotechnological Equipment, 2020 The present study aims at the use of transcriptomic data of wild barley (Hordeum spontaneum) under salt stress in detecting regulated metabolites and crosstalking signal transduction pathways that help plants withstand harsh conditions.
Aala Abdulaziz Abulfaraj
doaj +1 more source
Acute tryptophan depletion attenuates conscious appraisal of social emotional signals in healthy female volunteers [PDF]
, 2010 Rationale: Acute tryptophan depletion (ATD) decreases levels of central serotonin. ATD thus enables the cognitive effects of serotonin to be studied, with implications for the understanding of psychiatric conditions, including depression.
Beacher, Felix D C C +5 more
core +3 more sources
Two Adjacent Phenylalanines In the NMDA Receptor GluN2A Subunit M3 Domain Interactively Regulate Alcohol Sensitivity and Ion Channel Gating [PDF]
, 2017 The N-methyl-d-aspartate (NMDA) receptor is a key target of ethanol action in the central nervous system. Alcohol inhibition of NMDA receptor function involves small clusters of residues in the third and fourth membrane-associated (M) domains.
Dwyer, Donard S. +4 more
core +2 more sources
HeliyonBackground: Tryptophan is an essential amino acid with anti-inflammatory and immunomodulatory effects. However, the absorption of amino acids including tryptophan is relatively slower than the absorption of dipeptides. Therefore, we have two aims in this
Jae B. Park, Renee Peters
doaj +1 more source
Relationship between parasitic infection of Toxoplasma gondii, IL-2, TNF-α tryptophan and CD4+ count
Journal of Nature and Science of Medicine, 2019 Study Background: Toxoplasma gondii a protozoan and zoonotic infection can stimulate innate and adaptive immune responses. Aims and Objectives: This work was designed to determine relationship between parasitic infection of T. gondii, interleukin-2 (IL-2)
Mathew Folaranmi Olaniyan +2 more
doaj +1 more source
Journal of Spectral Imaging, 2019 Pompe disease (glycogen storage disease type II) is a lysosomal storage disorder due to a mutation in the gene that encodes acid alpha-glucosidase (GAA).
Laurence Dubreil +10 more
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States of quinolinic acid excess in urine: A systematic review of human studies
Frontiers in Nutrition, 2022 IntroductionQuinolinic acid is an intermediate compound derived from the metabolism of dietary tryptophan. Its accumulation has been reported in patients suffering a broad spectrum of diseases and conditions. In this manuscript, we present the results of
Marie Christelle Saade +4 more
doaj +1 more source