Results 111 to 120 of about 1,375,182 (353)

Disruption of Gut Microbiota‐Mediated De Novo NAD+ Synthesis Contributes to the Development of Polycystic Ovary Syndrome

Advanced Science, EarlyView.
This study demonstrates that patients with PCOS exhibit altered gut microbial profiles, and FMT from PCOS patients induces PCOS‐like symptoms in mice. Specifically, gut dysbiosis reduces 3‐HAA levels in the context of PCOS. Administration of 3‐HAA to mice alleviates PCOS by promoting de novo NAD+ synthesis.
Ke Chen, Huafeng Geng, Yang Zheng, Hongyang Xie, Rui Qin, Junyang Chen, Cong Ye   +6 more
wiley   +1 more source

A Viral RNA Silencing Suppressor Modulates Reactive Oxygen Species Levels to Induce the Autophagic Degradation of Dicer‐Like and Argonaute‐Like Proteins

Advanced Science, EarlyView.
Understanding the virus‐host arms race has been a fascinating topic in virology; contributing significantly to the development of treatments and control strategies for viral diseases. CHV1 employs a sophisticated counter‐defense mechanism in its fungal host by utilizing a viral silencing suppressor to inhibit fungal FMN reductase; thereby modulating ...
Shiyu Zhai, Tianxing Pang, Shiyu Peng, Shenshen Zou, Zhiping Deng, Nobuhiro Suzuki, Zhensheng Kang, Ida Bagus Andika, Liying Sun   +8 more
wiley   +1 more source

A Disturbance of Tryptophan Metabolism in Congenital Hypoplastic Anæmia [PDF]

, 1953
Kurt I. Altman, Gerald Miller
openalex   +1 more source

H2S Is a Potential Universal Reducing Agent for Prx6‐Type Peroxiredoxins

Advanced Science, EarlyView.
We report the identification of H2S as reducing agent for Prx6‐type peroxiredoxins. In contrast to common physiological reducing agents of other peroxiredoxins, HS− is small enough to access the active site of oxidized Prx6‐type enzymes in the fully‐folded protein conformation.
Lukas Lang, Laura Leiskau, Lea Bambach, Marcel Deponte   +3 more
wiley   +1 more source

TRYPTOPHAN METABOLISM

, 1949
Charles Heidelberger, Edward P. Abraham, Samuel Lepkovsky   +2 more
openalex   +2 more sources

Integrated analysis of bulk and single-cell RNA sequencing reveals the impact of nicotinamide and tryptophan metabolism on glioma prognosis and immunotherapy sensitivity

BMC Neurology
Background Nicotinamide and tryptophan metabolism play important roles in regulating tumor synthesis metabolism and signal transduction functions. However, their comprehensive impact on the prognosis and the tumor immune microenvironment of glioma is ...
Sen Wang, Shen Gao, Shaochong Lin, Xiaofeng Fang, Haopeng Zhang, Man Qiu, Kai Zheng, Yupeng Ji, Baijun Xiao, Xiangtong Zhang   +9 more
doaj   +1 more source

Excretion of conjugated 2-amino-3-hydroxyacetophenone by man, and its significance in tryptophan metabolism [PDF]

, 1955
C. E. Dalgliesh
openalex   +1 more source

Hepatic CBP/p300 Orchestrate Amino Acid‐Driven Gluconeogenesis through Histone Crotonylation

Advanced Science, EarlyView.
Hepatic CBP/p300 control amino acid‐driven gluconeogenesis by modulating histone crotonylation. This study identifies 2‐aminoadipate (2‐AAA) as a key metabolite that enhances crotonylation and activates amino acid and gluconeogenic gene expression.
Chunxiang Sheng, Tianjiao Li, Hong Lin, Xiaoqin Ma, Feiye Zhou, Mingzhu Li, Yiru Wang, Shushu Wang, Jialin Tan, Junmin Chen, Yulin Yang, Jianmin Liu, Yufang Bi, Jieli Lu, Xiao Wang, Libin Zhou   +15 more
wiley   +1 more source

The relation between thiamine, biotin and tryptophan metabolism, studied in the rat [PDF]

, 1955
C. E. Dalgliesh
openalex   +1 more source

Tryptophan Metabolism in Man * [PDF]

Journal of Clinical Investigation, 1964
Robert A. Good, Alfred F. Michael, Keith N. Drummond, John A. Anderson, Doris Doeden   +4 more
openaire   +3 more sources