Results 111 to 120 of about 1,437,430 (390)

Generation of superoxide and singlet oxygen from α-tocopherolquinone and analogues. [PDF]

, 2007
Three potential routes to generation of reactive oxygen species from a tocopherolquinone have been identified. The quinone of the water-soluble vitamin E analogue Trolox C (Trol-Q) is reduced by hydrated electron and isopropanol a hydroxyalkyl radical ...
Bisby, RH, Crisostomo, AG, Moreno, RB, Navaratnam, S, Wilkinson, JA   +4 more
core   +1 more source

Tryptophan Metabolite Indole‐3‐Aldehyde Induces AhR and c‐MYC Degradation to Promote Tumor Immunogenicity

Advanced Science, EarlyView.
Tryptophan metabolite Indole‐3‐aldehyde (I3A) downregulates cytosolic AhR and p‐ERK/c‐MYC proteins, together enhancing STAT3 phosphorylation and tumor immunogenicity. Overexpression of the Trp metabolic enzyme interleukin‐4‐induced gene‐1 (IL4I1) in tumor cells increases intracellular levels of I3A and enhances tumor immunogenicity.
Lei Cui, Zining Wang, Zixuan Guo, Hongxia Zhang, Yongxiang Liu, Huanling Zhang, Huan Jin, Feifei Xu, Xiaojuan Wang, Chunyuan Xie, Hui Guo, Tiantian Wang, Yanxun Lin, Qi Zhao, Penghui Zhou, Jing Tan, Jin‐Xin Bei, Peng Huang, Jinyun Liu, Xiaojun Xia   +19 more
wiley   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Tailoring a Functional Synthetic Microbial Community Alleviates Fusobacterium nucleatum‐infected Colorectal Cancer via Ecological Control

Advanced Science, EarlyView.
The bottom‐up strategy based on multiomics data is used for the SynCom design, and it successfully inhibited F. nucleatum growth and achieved stable colonization in vivo. In addition, it promoted tryptophan metabolism and secondary bile acid conversion, reduced lipid accumulation, relieved microbiome disorder, decreased inflammatory reaction, and ...
Zhongkun Zhou, Mengyue Yang, Hong Fang, Baizhuo Zhang, Yunhao Ma, Yongyuan Li, Yingjie Liu, Zeying Cheng, Yuanchun Zhao, Zhenzhen Si, Hongmei Zhu, Peng Chen   +11 more
wiley   +1 more source

Aryl hydrocarbon receptor dependent anti-inflammation and neuroprotective effects of tryptophan metabolites on retinal ischemia/reperfusion injury

Cell Death and Disease, 2023
Glaucoma is the major cause of irreversible blindness in the world characterized by progressive retinal neurodegeneration, in which local inflammation in retina is involved in persistent loss of retinal ganglion cells (RGCs).
Yijie Yang, Ning Wang, Li Xu, Yixin Liu, Lulu Huang, Mengyang Gu, Yue Wu, Wenyi Guo, Hao Sun   +8 more
doaj   +1 more source

The use of isotopic carbon in a study of the metabolism of anthanilic acid in Neurospora [PDF]

, 1949
The finding by Tatum, Banner, and Beadle (l), that the tryptophanless Neurospora mutant strain 10575 accumulates anthranilic acid, which in turn can be utilized for growth of strain 40008, has provided evidence that anthranilic acid is a biochemical ...
Langham, Wright H., Leifer, Edgar, Mitchell, Herschel K., Nyc, Joseph F.   +3 more
core  

Impact of bioactive substances on the gastrointestinal tract and performance of weaned piglets: a review [PDF]

, 2009
The EU ban on in-feed antibiotics has stimulated research on weaning diets as a way of reducing post-weaning gut disorders and growth check in pigs. Many bioactive components have been investigated but only few have shown to be effective.
Bosi, P., Janczyk, P., Koopmans, S.J., Lalles, J.P., Torrallardona, D.   +4 more
core   +3 more sources

Engineering Electron Transfer Flux between Cytochrome P450 Enzyme and P450 Reductase to Enhance Serotonin Production in Escherichia Coli

Advanced Science, EarlyView.
The electron transfer flux in CPR‐P450 catalytic system is systematically engineered through: i) enhancing electron transfer rate by redesigning the putative electron transfer pathway of CPR; ii) improving electron‐receiving rate by evolving the heme domain of tryptophan‐5‐hydroxylase (T5H); iii) enlarging electron supply by fine‐tuning NADPH synthesis.
Wenzhao Xu, Pengling Wei, Lirong Chen, Ling Gao, Xiaole Xia   +4 more
wiley   +1 more source

Microbiota-mediated skewing of tryptophan catabolism modulates CD4+ T cells in lupus-prone mice

iScience, 2022
Summary: A skewed tryptophan metabolism has been reported in patients with lupus. Here, we investigated the mechanisms by which it occurs in lupus-susceptible mice, and how tryptophan metabolites exacerbate T cell activation.
Josephine Brown, Georges Abboud, Longhuan Ma, Seung-Chul Choi, Nathalie Kanda, Leilani Zeumer-Spataro, Jean Lee, Weidan Peng, Joy Cagmat, Tamas Faludi, Mansour Mohamadzadeh, Timothy Garrett, Laura Mandik-Nayak, Alexander Chervonsky, Andras Perl, Laurence Morel   +15 more
doaj  

Evolution of substrate specificity in a recipient's enzyme following horizontal gene transfer [PDF]

, 2013
Despite the prominent role of horizontal gene transfer (HGT) in shaping bacterial metabolism, little is known about the impact of HGT on the evolution of enzyme function.
Abascal, Aldo R. Camacho-Zarco, Barona-Gomez, Brune, Carver, Collaborative Computational Project, Number 4 (CCP4), Dean, Depristo, Des Marais, Dittmar, Due, Francisco Barona-Gómez, Glykos, Guindon, Henn-Sax, Hess, Hodgson, Hu, Hughes, Humphrey, Ikeda, James, Jensen, Jensen, Jones, Jorgensen, Jung, Kane, Klassen, Kuper, Leaver-Fay, Lerat, Lianet Noda-García, MacKerell, Mauricio Carrillo-Tripp, McCoy, Murshudov, Nester, Noda-Garcia, Ohno, Pal, Parish, Paul Gaytán, Perrakis, Piatigorsky, Sofía Medina-Ruíz, Sterner, Tokuriki, Tokuriki, Treangen, Vilmos Fülöp, Vriend, Wright, Xie, Xie   +54 more
core   +1 more source