2‐oxoglutarate (2OG)‐dependent non‐heme iron (NHFe) enzymes constitute a family of enzymes that use 2OG and oxygen to catalyze the hydroxylation of unactivated C(sp3)–H bonds. These enzymes are of biological importance and therapeutic interest due to their role in regulating various cellular processes. Herein, we have rationally designed two classes of
Peter Windsor+3 more
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Impact of terminal ileal microbiota dysbiosis and tryptophan metabolism alterations on mental disorders in patients with Crohn's disease. [PDF]
Lin Y+6 more
europepmc +1 more source
In Vivo Biosynthesis and Direct Incorporation of Non‐Canonical Amino Acids into Proteins
Autonomous cells are engineered biological systems capable of biosynthesising and directly incorporating non‐canonical amino acids (ncAAs) into proteins. These systems have the potential to extend the applicability of the genetic code to enable large‐scale fermentative production of proteins carrying ncAAs.
Ivana Drienovska+2 more
wiley +1 more source
Dihydrosanguinarine enhances tryptophan metabolism and intestinal immune function via AhR pathway activation in broilers. [PDF]
Su Y, Wang M, Wu Z, Huang P, Zeng J.
europepmc +1 more source
Interferon enhances tryptophan metabolism by inducing pulmonary indoleamine 2,3-dioxygenase: its possible occurrence in cancer patients. [PDF]
Hiroaki Yasui+3 more
openalex +1 more source
Urinary N-methylnicotinamide and β-aminoisobutyric acid predict catch-up growth in undernourished Brazilian children [PDF]
Guerrant, RL+10 more
core +1 more source
A series of all‐cis ring fluorinated cyclohexylalanines with progressively increasing levels of vicinal fluorines, as well as 4‐fluorophenylalanine and pentafluoroarylphenylalanine were introduced into the WKYMVm peptide in place of its tyrosine residue, for assays against the G‐protein coupled formylpeptide receptor, FPR2.
David O'Hagan+6 more
wiley +1 more source
The role of tryptophan 2,3-dioxygenase in the hormonal control of tryptophan metabolism in isolated rat liver cells. Effects of glucocorticoids and experimental diabetes [PDF]
Mark Salter, C I Pogson
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Advancing Biocatalysis: Using Siloxanes to Solubilize and Stabilize Enzymes in Organic Solvents
Biocatalysis offers an attractive route in the development of more sustainable approaches in silicon chemistry. Given the propensity for enzymes to operate optimally in an aqueous environment there are obvious challenges to incorporating biocatalysts in organic solvents.
Najibeh Alizadeh+2 more
wiley +1 more source