Results 221 to 230 of about 1,375,182 (353)

Hydrogen‐Deuterium Exchange Defines Ligand‐Induced Conformational Changes to the Class III Biotin Protein Ligase from Saccharomyces cerevisiae

open access: yesChemBioChem, EarlyView.
Hydrogen‐deuterium exchange mass spectrometry validated AlphaFold structural prediction of the class III biotin protein ligase (BPL) from Saccharomyces cerevisiae, and revealed a structured domain in the N‐terminal extension characteristic to this class of BPL.
Louise M. Sternicki   +6 more
wiley   +1 more source

ThiF‐Like Enzyme Chemistry in Primary and Secondary Metabolism

open access: yesChemBioChem, EarlyView.
ThiF‐like enzymes are a widespread protein family found in disparate biosynthetic pathways. They are unified by their use of an NTP to modify a carboxylate, generating an activated species prone to nucleophilic addition. This common intermediate is then targeted by diverse nucleophiles, including persulfide or amino acid side chains, to yield a variety
Keelie S. Butler   +2 more
wiley   +1 more source

Tryptophan metabolism and ischemic stroke: An intricate balance. [PDF]

open access: yesNeural Regen Res
Yao C   +8 more
europepmc   +1 more source

Influence of Adenine-induced Renal Failure on Tryptophan-niacin Metabolism in Rats [PDF]

open access: bronze, 2001
Tsutomu Fukuwatari   +4 more
openalex   +1 more source

Reaction Engineering of In Vitro Natural Product Biosynthesis: Challenges and Strategies

open access: yesChemBioChem, EarlyView.
The yield and turnover of in vitro natural product biosynthesis, and even its feasibility, are determined by intermolecular interactions. Reaction engineering allows to improve the performance of such complex biocatalytic systems. Natural products are widely used as pharmaceuticals and agrochemicals, or as active ingredients in food and cosmetics ...
Elsa Sánchez‐García   +2 more
wiley   +1 more source

Biocompatible Chemistry: A Plug‐and‐Play Toolbox for Chemical Biology Research

open access: yesChemBioChem, EarlyView.
The “plug‐and‐play” nature of biocompatible chemistry makes it a powerful toolbox for investigating complicated biological systems and producing drug leads for clinical usages. This review summarizes the commonly used biocompatible reactions and the recent advances of their representative applications in chemical biology research, thus highlighting the
Adam R. Lovato, Zeng Lin, Qingfei Zheng
wiley   +1 more source

Targeting Cryptochromes in Chronic Diseases

open access: yesCell Biology International, EarlyView.
ABSTRACT The circadian clock generates 24‐h molecular rhythms through transcription–translation negative feedback loops (TTFLs) and regulates daily physiological processes such as sleep–wake cycles, body temperature, hormone secretion, metabolism, and immune function.
Takuro Toda, Tsuyoshi Hirota
wiley   +1 more source

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