Results 101 to 110 of about 22,323 (211)

The Biology of Thymic Stromal Lymphopoietin (TSLP) [PDF]

, 2013
Originally shown to promote the growth and activation of B cells, thymic stromal lymphopoietin (TSLP) is now known to have wide-ranging impacts on both hematopoietic and nonhematopoietic cell lineages, including dendritic cells, basophils, eosinophils, mast cells, CD4⁺, CD8⁺ and natural killer T cells, B cells and epithelial cells. While TSLP's role in
Steven F, Ziegler, Florence, Roan, Bryan D, Bell, Thomas A, Stoklasek, Masayuki, Kitajima, Hongwei, Han   +5 more
openaire   +2 more sources

Targeting thymic stromal lymphopoietin in nasal type 2 inflammation

Eye & ENT Research
Epithelial cell‐derived thymic stromal lymphopoietin (TSLP) plays a crucial role in mediating type 2 immune responses, which is one of the key underlying pathophysiological mechanisms of allergic rhinitis (AR) and most presentations of chronic ...
Xintong Li, Jingjing Guo, Jing Song, Ming Wang   +3 more
doaj   +1 more source

Dimeric procyanidins as modulators of airway inflammation in the context of allergic asthma : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy (PhD) in Human Physiology at Massey University, Manawatū, Palmerston North, New Zealand [PDF]

, 2017
Procyanidins are polyphenolic compounds that have come to be known as biologically active in the context of promoting human health. Epidemiological evidence suggests that populations that consume diets rich in procyanidins are less susceptible to ...
Coleman, Sara L
core  

MERS-CoV Infection and Its Impact on the Expression of TSLP Cytokine and IgG Antibodies: An In Vivo and In Vitro Study

Infection and Drug Resistance
Ayman Mubarak,1 Mahfoudh Alqoufail,1 Saeedah Almutairi,1 Bahauddeen Alrfaei,2 Abdulaziz Almotairi,3 Ibrahim Aziz,1 Taghreed N Almanaa,1 Mostafa A Abdel-Maksoud,1 Mohamed A Farrag,1 Allolo D Aldreiwish,4 Maaweya E Awadalla,5 Bandar Alosaimi,5 Wael ...
Mubarak A, Alqoufail M, Almutairi S, Alrfaei B, Almotairi A, Aziz I, Almanaa TN, Abdel-Maksoud MA, Farrag MA, Aldreiwish AD, Awadalla ME, Alosaimi B, Alturaiki W   +12 more
doaj  

TSLP Expression: Cellular Sources, Triggers, and Regulatory Mechanisms

Allergology International, 2012
Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine initially identified in the culture supernatant of a thymic stromal cell line. Highly expressed in the epidermis in skin lesions of atopic dermatitis patients, TSLP was subsequently found to be
Toshiro Takai
doaj   +1 more source

Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma. [PDF]

, 2019
Asthma is a common disorder of the airways characterized by airway inflammation and by decline in lung function and airway remodeling in a subset of asthmatics.
Broide, David H, Hur, Gyu Young
core  

Assessing D‐Squame as a Minimally Invasive Technique to Evaluate the Cutaneous Immune Response mRNA in a Dog Model of Canine Atopic Dermatitis

Veterinary Dermatology, EarlyView.
ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon, Marion Mosca, Nadège Milhau, Mélanie Legain, Adrien Idée, Didier Pin   +5 more
wiley   +1 more source

Asthma Biologics Across the T2 Spectrum of Inflammation in Severe Asthma: Biomarkers and Mechanism of Action

Journal of Asthma and Allergy
Andrew W Lindsley,1 Njira Lugogo,2 Kaitlin AG Reeh,3 Joseph Spahn,3 Jane R Parnes1 1Amgen Inc., Thousand Oaks, CA, USA; 2Michigan Medicine Asthma Program, University of Michigan, Ann Arbor, MI, USA; 3AstraZeneca, Gaithersburg, MD, USACorrespondence ...
Lindsley AW, Lugogo N, Reeh KAG, Spahn J, Parnes JR   +4 more
doaj  

Thymic stromal lymphopoietin in leukemia: A double-edged sword?

Leukemia Research Reports
Thymic stromal lymphopoietin (TSLP) is a cytokine expressed by various cell types. It is involved in the development of allergies, autoimmune diseases, and cancers.
Xing Zou, Mengmeng Gu, Yue Su, Dayong Yao, Hao Gang, Yang Li, Ce Shi   +6 more
doaj   +1 more source

Thymic Stromal Lymphopoietin Signaling Pathway Inhibition Attenuates Airway Inflammation and Remodeling in Rats with Asthma

Cellular Physiology and Biochemistry, 2018
Background/Aims: Thymic stromal lymphopoietin (TSLP) is a cytokine that plays diverse roles in the regulation of immune responses. However, a detailed understanding of the TSLP signaling pathway in asthma remains elusive.
Zhe  Cheng, Xi Wang, Ling-Ling Dai, Liu-Qun Jia, Xiao-Gang Jing, Ying Liu, Huan Wang, Peng-Fei Li, Lin An, Meng Liu   +9 more
doaj   +1 more source