Results 81 to 90 of about 1,573 (166)

Research progress on the tsRNA biogenesis, function, and application in lung cancer

Non-coding RNA Research
In recent years, there has been a mounting occurrence of lung cancer, which stands as one of the most prevalent malignancies globally. This rise in incidence poses a significant hazard to human health, making lung cancer a matter of grave concern. It has been shown that tRNA-derived small non-coding RNA (tsRNA) is involved in the development of tumors,
Yu Chen, Zhuowei Shao, Shibo Wu
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Regulation of plant gene expression by tsRNAs in response to abiotic stress

PeerJ
Objective Transfer RNA-derived small RNAs (tsRNAs) are emerging regulators of gene expression in response to abiotic stress. This review aims to summarize recent advances in the classification, biogenesis, and biological functions of tsRNAs, with a focus on their roles in plant stress responses and the methodologies for investigating these molecules.
Chunmei Li, Jing Zhu, Han Jin, Haotian Feng, Haimin Zhuang, Zijun Du, Guolin Zhu, Haiyang He, Fuyang Ye, Zhaohui Mo, Qingtao Hu, Zhenbang Chen, Kai Liu, Xiaorong Wan   +13 more
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Oncogenic-tsRNA: A novel diagnostic and therapeutic molecule for cancer clinic

Journal of Cancer
tsRNA (tRNA-derived small RNA) is derived from mature tRNA or precursor tRNA (pre-tRNAs). It is lately found that tsRNA's aberrant expression is associated with tumor occurrence and development, it may be used a molecule of diagnosis and therapy. Based on the cleavage position of pre-tRNAs or mature tRNAs, tsRNAs are classified into two categories ...
Chen, Lin, Wu, Yao, Tang, Qi, Tang, Faqing   +3 more
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tRNA-derived small RNAs: their role in the mechanisms, biomarkers, and therapeutic strategies of colorectal cancer

Journal of Translational Medicine
Colorectal cancer (CRC) is the third most prevalent malignancy and the second leading cause of cancer-related mortality worldwide, with an increasing shift towards younger age of onset.
Bo Zhang, Yanru Pan, Zhe Li, Kefeng Hu
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The biological role and molecular mechanism of transfer RNA-derived small RNAs in tumor metastasis

Frontiers in Oncology
Tumor metastasis is a significant contributor to increased cancer mortality. Transfer RNA-derived small RNAs (tsRNAs), a class of endogenous non-coding RNA molecules, play crucial functional roles in various physiological processes, including the ...
Haotian Dong, Haotian Dong, Chengyuan Ye, Xiaohan Ye, Jianing Yan, Guoliang Ye, Yongfu Shao, Yongfu Shao   +7 more
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tRNA-derived small RNAs in digestive tract diseases: Progress and perspectives

Genes and Diseases
tRNA-derived small RNAs (tsRNAs) are non-coding small RNAs that are produced through the precise cleavage of tRNA molecules under specific conditions. tsRNA has multiple functions, including inhibiting translation, acting in association with classical ...
Mingrui Liu, Xiaojun Zhuang, Haiqing Zhang, Weidong Ji, Gang Yuan   +4 more
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Serum exosome smallRNA array analysis identifies 5’tiRNA-PheGAA and tRF-1-IleAAT as potential biomarkers for diagnosis of rheumatoid arthritis

Immunobiology
tRNA-derived small RNAs (tsRNAs) are a recently identified class of non-coding RNAs (ncRNAs) that exhibit aberrant expression in various diseases and are involved in multiple pathological processes.
Yuanyuan Li, Meiling Xu, Nan Zhao, Chong Qi, Tingshuang Xu   +4 more
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Targeting glycolytic reprogramming by tsRNA-0032 for treating pathological lymphangiogenesis

Cell Death & Disease
Abstract Lymphangiogenesis is vital for tissue fluid homeostasis, immune function, and lipid absorption. Disruption of this process is implicated in diseases such as cancer, inflammation, and autoimmune disorders. In this study, we elucidate the role of tsRNA-0032 in lymphangiogenesis and its molecular mechanisms.
Fan Ye, Ziran Zhang, Lianjun Shi, Shuting Lu, Xiumiao Li, Wan Mu, Qin Jiang, Biao Yan   +7 more
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Prognostic, diagnostic and clinicopathological roles of tsRNAs: a meta-analysis in breast cancer

European Journal of Medical Research
Breast cancer (BC) is one of the most common malignancies in women and the leading cause of cancer-related death in women. The newly emerged non-coding RNAs tsRNAs (tRNA-derived small RNAs) play an important role in the occurrence and development of BC ...
Lu-Jue Gao, Si-Xun Zhu, Ying-Yi Wei, Hua-Wei Meng, Jing Gu, Hao Zhang, Li-Juan Dai   +6 more
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Advances in the study of tsRNA as diagnostic and prognostic biomarkers in cancer

Zhenduanxue lilun yu shijian, 2023
Transfer RNA (tRNA) promotes the protein translation process by binding with corresponding amino acids and transporting them to the ribosome, emphasizing the vital role of tRNA in protein translation. Transfer RNA-derived small RNA (tsRNA) are fragments originating from tRNA and are produced when these tRNA are cleaved.
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