Results 71 to 80 of about 1,573 (166)

Unravelling tRNA fragments in DENV pathogenesis: Insights from RNA sequencing

Scientific Reports
Small non-coding RNAs (sncRNAs) derived from tRNAs are known as tRNA-derived small RNAs (tsRNAs). These tsRNAs are further categorized into tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs), which play significant roles in the various molecular ...
Deeksha Madhry, Kiran Kumari, Varsha Meena, Riya Roy, Bhupendra Verma   +4 more
doaj   +1 more source

From Cell‐Free Transcriptomes to Single‐Cell Landscapes: Biomarker Discovery and Originating Cell Alteration Analysis via Graph Matrix Factorization

Advanced Science, Volume 13, Issue 29, 22 May 2026.
CellFreeGMF traces plasma cfRNA to likely originating cell types by integrating single‐cell atlases with graph‐regularized matrix factorization. The method decomposes cfRNA profiles into sample–cell contributions to reconstruct pseudo single‐cell expression.
Wenxiang Zhang, Wenjing Zhang, Hang Wei, Shiyan Liu, Junliang Shang, Weijie Gong, Hanwen Cheng, Xiujuan Lei, Yuhui Kou, Baoguo Jiang   +9 more
wiley   +1 more source

tsRNA modifications: An emerging layer of biological regulation in disease

Journal of Advanced Research
Transfer RNA (tRNA)-derived small RNA (tsRNA) represents an important and increasingly valued type of small non-coding RNA (sncRNA). The investigation of tRNA and tsRNA modification crosswalks has not only provided novel insights into the information and functions of tsRNA, but has also expanded the diversity and complexity of the tsRNA biological ...
Yaomin Liang, Ding Ji, Xiaoling Ying, Renqiang Ma, Weidong Ji   +4 more
openaire   +2 more sources

A Review of the Effects of Maternal and Paternal Obesity on Neurodevelopmental Disorders and Related Neurobiology in Rodent and Human Offspring

Obesity Reviews, Volume 27, Issue 5, May 2026.
ABSTRACT Obesity is one of the most prevalent health problems worldwide, and global obesity rates continue to rise. Consequently, rates of obesity in expecting mothers and fathers have also increased. The Developmental Origins of Health and Disease (DOHaD) hypothesis postulates that early‐life exposure to adverse environmental conditions contributes to
Hannah Chadwick, Victorio Bambini Junior, Neil Dawson, Cheryl A. Hawkes   +3 more
wiley   +1 more source

Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases

Cell Proliferation, Volume 59, Issue 4, April 2026.
Engineered BMSCs and vesicles enhance therapy effects for bone diseases via multi‐strategic approaches. ABSTRACT Bone‐related diseases (e.g., osteoporosis, osteoarthritis and fractures) exhibit a rising global incidence, imposing significant burdens on both quality of life and healthcare systems.
Xuemei Long, Dan Tan, Qianke Tao, Qiaonan Ye, Luwen Ye, Qing Li, Jingang Xiao   +6 more
wiley   +1 more source

Emerging Roles of tsRNAs: Novel Biomarkers and Therapeutic Targets in Gynecological Oncology

Journal of Cancer Biomoleculars and Therapeutics
Transfer RNA-derived small RNA (tsRNAs) are a diverse group of non-coding RNAs that play key roles in controlling gene expression and the body's response to stress.
Vajihe Hazari
doaj   +1 more source

tsRNADisease: a manually curated database of tsRNAs associated with human disease

Journal of Genetics and Genomics
tRNA-derived small RNAs (tsRNAs), as a class of regulatory small noncoding RNA, have been implicated in a wide variety of human diseases. Large amounts of tsRNA-disease associations have been identified in recent years from accumulating studies. However, repositories for cataloging the detailed information on tsRNA-disease associations are scarce.
Hui Yang, Shaoying Zhu, Huijun Wei, Wei Huang, Qi Chen, Yungang He, Kun Lv, Zhen Yang   +7 more
openaire   +2 more sources

Unveiling the hidden world of transfer RNA-derived small RNAs in inflammation

Journal of Inflammation
Transfer RNA-derived small RNAs (tsRNAs) are a newly discovered class of small noncoding RNAs (sncRNAs) that include tRNA-derived stress-induced RNAs (tiRNAs) and tRNA-derived fragments (tRFs).
Peiru Qiu, Qi Jiang, Haojun Song
doaj   +1 more source

Plasma tsRNA Signatures Serve as a Novel Biomarker for Bladder Cancer

Cancer Science
ABSTRACTBladder cancer (BLCA) is one of the most common tumors of the urinary tract. The diagnosis of BLCA is mostly by invasive tests, which are damaging and unsuitable for early screening. Current non‐invasive diagnostic modalities are insufficient in sensitivity and specificity.
Xinyan Xu, Jinbang Chen, Ming Bai, TianYao Liu, Shoubin Zhan, Jiazheng Li, YuanChun Ma, Yulin Zhang, Liming Wu, Zihan Zhao, Siyang Liu, Xi Chen, Feng Fang, Hongqian Guo, Ying Sun, Rong Yang   +15 more
openaire   +2 more sources

tsRNA-25172 inhibits aldosterone secretion in aldosterone-producing adenomas

Endocrine Connections
The pathophysiology of aldosterone-producing adenomas (APAs) is characterized by aldosterone hypersecretion. Transfer RNA-derived small RNAs (tsRNAs) are novel non-coding RNAs, which are involved in multiple biological processes. However, the role of tsRNAs in aldosterone synthesis and APAs remains poorly understood.
Qiwei Fan, Liqing Liu, Zhihua Jiang, Shanshan Feng, Jiancheng Wang, Jianrong Chen   +5 more
openaire   +3 more sources