Results 51 to 60 of about 1,573 (166)

Dysregulated transfer RNA-derived small RNAs as potential gastric cancer biomarkers

Experimental Biology and Medicine
Gastric cancer (GC) is the kind of carcinoma that has the highest rates of morbidity and death worldwide. In the early stages of GC, there is currently an absence of sensitive and specific biomarkers. The newly-discovered class of non-coding RNAs (ncRNAs)
Jie Yuan, Wenchao Gu, Tianxin Xu, Yan Zhang, Lei Shen, Jianliang Yan, Xi Guan, Haidan Chu, Ruoyu Yuan, Shaoqing Ju   +9 more
doaj   +1 more source

Emerging roles of tRNA-derived small RNAs in injuries [PDF]

PeerJ
tRNA-derived small RNAs (tsRNAs) are a novel class of small noncoding RNAs, precisely cleaved from tRNA, functioning as regulatory molecules. The topic of tsRNAs in injuries has not been extensively discussed, and studies on tsRNAs are entering a new era.
Mengjun Wang, Junfeng Guo, Wei Chen, Hong Wang, Xiaotong Hou   +4 more
doaj   +2 more sources

Global Profile of tRNA-Derived Small RNAs in Pathological Cardiac Hypertrophy Plasma and Identification of tRF-21-NB8PLML3E as a New Hypertrophy Marker

Diagnostics, 2023
Background: It remains unclear whether transfer RNA-derived small RNAs (tsRNAs) play a role in pathological cardiac hypertrophy (PCH). We aimed to clarify the expression profile of tsRNAs and disclose their relationship with the clinical phenotype of PCH
Jingyi Xu, Buyun Qian, Feng Wang, Ying Huang, Xinxin Yan, Ping Li, Qian Zhang, Yuan Li, Kangyun Sun   +8 more
doaj   +1 more source

Signaling Pathway–Biomarker Coupling for Precision Therapy in Rheumatoid Arthritis: Mechanistic Insights, Translational Bottlenecks, and Emerging Strategies

ACR Open Rheumatology, Volume 8, Issue 8, August 2026.
Rheumatoid arthritis (RA) is a heterogeneous autoimmune disease. Despite advances in targeted therapies, significant interindividual variability in treatment response and a lack of precise predictive tools limit the achievement of treat‐to‐target goals.
Shijie Meng, Feng Xing, Yuyang Luo, Jianxin Li, Yingchen Ni, Fengyuan Zhang, Hua Xu, Youhua Wang, Weidong Zhang   +8 more
wiley   +1 more source

Reprogramming Glial Cell Metabolism via a tRNA Fragment Preserves Vision in Retinal Neurodegeneration

MedComm, Volume 7, Issue 8, August 2026.
Under oxidative and excitotoxic stress, Müller cell‐derived 5′tiRNA‐His‐GTG contributes to retinal neurodegeneration. Pathological stimuli increase ANG‐dependent production of 5′tiRNA‐His‐GTG, which suppresses LPCAT1 expression and disrupts phosphatidylcholine (PC)‐mediated glycerophospholipid metabolism.
Yuke Ji, Sha Liu, Ying Zhang, Junya Zhu, Chang Huang, Ya Zhao, Jiao Xia, Wan Mu, Jin Yao, Biao Yan   +9 more
wiley   +1 more source

Transfer RNA-derived small RNAs and their potential roles in the therapeutic heterogeneity of sacubitril/valsartan in heart failure patients after acute myocardial infarction

Frontiers in Cardiovascular Medicine, 2022
BackgroundIt has been reported that sacubitril/valsartan can improve cardiac function in acute myocardial infarction (AMI) patients complicated by heart failure (HF). However, a number of patients cannot be treated successfully; this phenomenon is called
Jia Su, Jia Su, Ji Cheng, Yingchu Hu, Yingchu Hu, Qinglin Yu, Zhenwei Li, Zhenwei Li, Jiyi Li, Nan Zheng, Zhaoxia Zhang, Zhaoxia Zhang, Jin Yang, Xiaojing Li, Zeqin Zhang, Zeqin Zhang, Yong Wang, Yong Wang, Keqi Zhu, Weiping Du, Weiping Du, Xiaomin Chen, Xiaomin Chen   +22 more
doaj   +1 more source

Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers

Genes and Diseases
With the development of sequencing technology, transfer RNA (tRNA)-derived small RNAs (tsRNAs) have received extensive attention as a new type of small noncoding RNAs.
Yu Zhang, Xinliang Gu, Yang Li, Yuejiao Huang, Shaoqing Ju   +4 more
doaj   +1 more source

Embryonic Mediators of Embryo–Uterus Communication, Implantation and Pregnancy

Molecular Reproduction and Development, Volume 93, Issue 8, August 2026.
ABSTRACT Successful reproduction in eutherian mammals requires intimate connections between the embryo and uterus, involving adhesion, attachment and placentation, with or without invasion of the endometrium. The complex dialogue between embryo and uterus involves numerous molecules and pathways.
Keith E. Latham
wiley   +1 more source

tRNA-derived small RNAs (tsRNAs): establishing their dominance in the regulation of human cancer

Frontiers in Genetics
The main function of transfer RNAs (tRNAs) is to carry amino acids into the ribosome and synthesize proteins under the guidance of messenger RNAs (mRNAs).
Li Gong, Yajie Hu, Ling Pan, Ling Pan, Yufeng Cheng, Yufeng Cheng   +5 more
doaj   +1 more source

Epididymosome‐Supplemented Extender Induces Changes in Morpho‐Functional Traits and microRNA Levels of Post‐Thaw Sperm and Improves Embryo Developmental Potential

Molecular Reproduction and Development, Volume 93, Issue 8, August 2026.
ABSTRACT While molecular signature contributes to sperm quality and fertility potential, sperm may lost key molecules during cryopreservation. Since sperm cells are transcriptionally inert and rely on interactions with epididymosomes (epEVs) to acquire molecules, herein, we investigated the effects of the addition of epEVs to the cryopreservation ...
Laura Gabrielli Haupenthal, Maria Alice de Almeida, Cibele Maria Prado, Amanda Nespolo Silva, Gabriela Melendes Schneider, Paola Maria da Silva Rosa, Flávio Vieira Meirelles, Juliano Coelho da Silveira, Felipe Perecin, Maíra Bianchi Rodrigues Alves   +9 more
wiley   +1 more source