Results 31 to 40 of about 1,573 (166)

Gut Commensal Klebsiella pneumoniae Extracellular Vesicles Shape a Liver Microenvironment Conducive to Gut-Liver Bacterial Translocation and Pro-Tumorigenic Processes. [PDF]

J Extracell Vesicles
ABSTRACT Bacterial extracellular vesicles (EVs) are emerging mediators of host–microbe communication; however, their role in human disease remains unclear. Here, we identify two bacterial small tRNAs (tsRNAs) enriched in gut commensal Klebsiella pneumoniae‐derived EVs (KpEVs) that are markedly elevated in the serum of patients with hepatocellular ...
Tsubaki S, Nashimoto S, Tanaka R, Toyomoto T, Tsutsuki H, Kato K, Nakayama J, Kimura K, Oshima K, Yamamoto Y, Okusaka T, Esaki M, Kawai N, Ota N, Yoshioka Y, Ochiya T, Ochiya T, Saito Y, Sawa T, Hozumi K, Matsuzaki J, Tsugawa H.   +21 more
europepmc   +2 more sources

tRF-Gln-CTG-026 ameliorates liver injury by alleviating global protein synthesis

Signal Transduction and Targeted Therapy, 2023
tsRNAs (tRNA-derived small RNAs), as products of the stress response, exert considerable influence on stress response and injury regulation. However, it remains largely unclear whether tsRNAs can ameliorate liver injury. Here, we demonstrate the roles of
Sunyang Ying, Pengcheng Li, Jiaqiang Wang, Kaiqiong Chen, Yu Zou, Moyu Dai, Kai Xu, Guihai Feng, Changjian Zhang, Haiping Jiang, Wei Li, Ying Zhang, Qi Zhou   +12 more
doaj   +1 more source

Transfer RNA-Derived Small RNAs: Novel Regulators and Biomarkers of Cancers

Frontiers in Oncology, 2022
Transfer RNA-derived small RNAs (tsRNAs) are conventional non-coding RNAs (ncRNAs) with a length between18 and 40 nucleotides (nt) playing a crucial role in treating various human diseases including tumours.
Bi-Fei Fu, Chao-Yang Xu
doaj   +1 more source

Transfer RNA-derived small RNA: an emerging small non-coding RNA with key roles in cancer

Experimental Hematology & Oncology, 2022
Transfer RNAs (tRNAs) promote protein translation by binding to the corresponding amino acids and transporting them to the ribosome, which is essential in protein translation.
Xinliang Gu, Yu Zhang, Xinyue Qin, Shuo Ma, Yuejiao Huang, Shaoqing Ju   +5 more
doaj   +1 more source

The function of tRNA-derived small RNAs in cardiovascular diseases

Molecular Therapy: Nucleic Acids
tRNA-derived small RNAs (tsRNAs) constitute a subgroup of small noncoding RNAs (ncRNAs) originating from tRNA molecules. Their rich content, evolutionary conservatism, high stability, and widespread existence makes them significant in disease research ...
Yan Zhao, Kai Wang, Chun Zhao, Ning Liu, Zhihong Wang, Wenting Yang, Zewei Cheng, Luyu Zhou, Kun Wang   +8 more
doaj   +1 more source

Biological function and clinical application prospect of tsRNAs in digestive system biology and pathology

Cell Communication and Signaling, 2023
tsRNAs are small non-coding RNAs originating from tRNA that play important roles in a variety of physiological activities such as RNA silencing, ribosome biogenesis, retrotransposition, and epigenetic inheritance, as well as involvement in cellular ...
Juan Du, Tianyi Huang, Zhen Zheng, Shuai Fang, Hongxia Deng, Kaitai Liu   +5 more
doaj   +1 more source

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder [PDF]

Science, 2016
Offspring affected by sperm small RNAsPaternal dietary conditions in mammals influence the metabolic phenotypes of offspring. Although prior work suggests the involvement of epigenetic pathways, the mechanisms remains unclear. Two studies now show that altered paternal diet affects the level of small RNAs in mouse sperm.
Chen, Qi, Yan, Menghong, Cao, Zhonghong, Li, Xin, Zhang, Yunfang, Shi, Junchao, Feng, Gui-hai, Peng, Hongying, Zhang, Xudong, Zhang, Ying, Qian, Jingjing, Duan, Enkui, Zhai, Qiwei, Zhou, Qi   +13 more
openaire   +4 more sources

tRNA-derived small RNAs: novel regulators of cancer hallmarks and targets of clinical application

Cell Death Discovery, 2021
tRNAs are a group of conventional noncoding RNAs (ncRNAs) with critical roles in the biological synthesis of proteins. Recently, tRNA-derived small RNAs (tsRNAs) were found to have important biological functions in the development of human diseases ...
Xizhe Li, Xianyu Liu, Deze Zhao, Weifang Cui, Yingfang Wu, Chunfang Zhang, Chaojun Duan   +6 more
doaj   +1 more source

Differential Expression Analysis of tRNA-Derived Small RNAs from Subcutaneous Adipose Tissue of Obese and Lean Pigs

Animals, 2022
Epigenetic factors, including non-coding RNA regulation, play a vital role in the development of obesity and have been well researched. Transfer RNA-derived small RNA (tsRNA) is a class of non-coding RNA proven to be involved in various aspects of ...
Hao Gu, Mailin Gan, Linghui Wang, Yiting Yang, Jinyong Wang, Lei Chen, Shunhua Zhang, Ye Zhao, Lili Niu, Dongmei Jiang, Yiwu Chen, Anan Jiang, Linyuan Shen, Li Zhu   +13 more
doaj   +1 more source

Altered Expressions of Transfer RNA-Derived Small RNAs and microRNAs in the Vitreous Humor of Proliferative Diabetic Retinopathy

Frontiers in Endocrinology, 2022
PurposeWe sought to reveal the expression profiles of transfer RNA-derived small RNAs (tsRNAs) and microRNAs (miRNAs) in the vitreous humor of patients with proliferative diabetic retinopathy (PDR).MethodsVitreous humor samples were obtained from PDR ...
Yan Yang, Yan Yang, Wenyun Yue, Wenyun Yue, Nan Wang, Nan Wang, Zicong Wang, Zicong Wang, Bingyan Li, Bingyan Li, Jun Zeng, Jun Zeng, Shigeo Yoshida, Chun Ding, Chun Ding, Yedi Zhou, Yedi Zhou   +16 more
doaj   +1 more source