Results 21 to 30 of about 1,573 (166)

A Novel Serum tsRNA for Diagnosis and Prediction of Nephritis in SLE [PDF]

Frontiers in Immunology, 2021
ObjectiveDysregulation of transfer RNA (tRNA)-derived small noncoding RNA (tsRNA) signatures in human serum has been found in various diseases. Here, we determine whether the signatures of tsRNAs in serum can serve as biomarkers for diagnosis or prognosis of systemic lupus erythematosus (SLE).MethodsInitially, small RNA sequencing was employed for the ...
Ping Yang, Xiaoshan Zhang, Shanshan Chen, Yue Tao, Mingzhe Ning, Yijia Zhu, Jun Liang, Wei Kong, Bo Shi, Zhiyang Li, Han Shen, Yanbo Wang   +11 more
openaire   +3 more sources

Deciphering the tRNA-derived small RNAs: origin, development, and future

Cell Death and Disease, 2021
Transfer RNA (tRNA)-derived small RNAs (tsRNAs), a novel category of small noncoding RNAs, are enzymatically cleaved from tRNAs. Previous reports have shed some light on the roles of tsRNAs in the development of human diseases.
Bowen Liu, Jinling Cao, Xiangyun Wang, Chunlei Guo, Yunxia Liu, Tianjiao Wang   +5 more
doaj   +1 more source

tsRNAs: new players in mammalian retrotransposon control [PDF]

Cell Research, 2017
A recent study led by Professor Rob Martienssen in Cell showed that 3'-tRNA-derived small RNAs can suppress long terminal repeat retrotransposon activity in mammalian cells by mechanisms independent of DNA-associated epigenetic marks, suggesting how the genome may defend itself from retrotransposon invasion during epigenetic reprogramming.
Zhang, Yunfang, Shi, Junchao, Chen, Qi
openaire   +4 more sources

Altered Expression of Transfer-RNA-Derived Small RNAs in Human With Rheumatic Heart Disease

Frontiers in Cardiovascular Medicine, 2021
Rheumatic heart disease (RHD) remains a severe public health problem in developing countries. Atrial fibrillation (AF) is a medical complication of RHD.
Zhao-yu Yang, Zhao-yu Yang, Peng-fei Li, Zhi-qing Li, Tao Tang, Tao Tang, Wei Liu, Wei Liu, Yang Wang, Yang Wang   +9 more
doaj   +1 more source

m⁵C-Modified tRF3b-Cys^GCA-23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4. [PDF]

Adv Sci (Weinh)
In this study, we identified an NSUN6‐dependent m5C‐modified tsRNA, m5C‐tRF3b CysGCA‐23 (mtRC), that is downregulated in BC and inversely correlated with disease progression. Mechanistically, mtRC suppresses BC malignancy by stabilizing RBM4, attenuating glycolysis, and thereby limiting H3K18 lactylation–mediated activation of IL1RAP and VASH2 ...
Ying X, Huang Y, Huang J, Cai Q, Zhang D, Chen C, Nie Y, Yang B, Li C, Hu W, Xiong C, Zhang C, Ji D, Liang Y, Yang M, Wu W, Ji W.   +16 more
europepmc   +2 more sources

Genome-wide interrogation of transfer RNA-derived small RNAs in a mouse model of traumatic brain injury

Neural Regeneration Research, 2022
Transfer RNA (tRNA)-derived small RNAs (tsRNAs) are a recently established family of regulatory small non-coding RNAs that modulate diverse biological processes.
Xiao-Jian Xu, Meng-Shi Yang, Bin Zhang, Qian-Qian Ge, Fei Niu, Jin-Qian Dong, Yuan Zhuang, Bai-Yun Liu   +7 more
doaj   +1 more source

tsRNAs: The Swiss Army Knife for Translational Regulation [PDF]

Trends in Biochemical Sciences, 2019
tRNA-derived small RNAs (tsRNAs, or tRFs) are a new category of regulatory noncoding RNAs with versatile functions. Recent emerging studies have begun to unveil distinct features of tsRNAs based on their sequence, RNA modifications, and structures that differentially impact their functions towards regulating multiple aspects of translational control ...
Junchao Shi, Yunfang Zhang, Tong Zhou, Qi Chen   +3 more
openaire   +4 more sources

Digging out the biology properties of tRNA-derived small RNA from black hole

Frontiers in Genetics, 2023
An unique subclass of functional non-coding RNAs generated by transfer RNA (tRNA) under stress circumstances is known as tRNA-derived small RNA (tsRNA).
Hengmei Shi, Jiaheng Xie, Shengbin Pei, Danni He, Huyang Hou, Shipeng Xu, Ziyi Fu, Xiaoyan Shi   +7 more
doaj   +1 more source

Transfer RNAs-derived small RNAs and their application potential in multiple diseases

Frontiers in Cell and Developmental Biology, 2022
The role of tRNAs is best known as adapter components of translational machinery. According to the central dogma of molecular biology, DNA is transcribed to RNA and in turn is translated into proteins, in which tRNA outstands by its role of the cellular ...
Xiaohua Chu, Chenyang He, Bo Sang, Chaofei Yang, Chong Yin, Mili Ji, Airong Qian, Ye Tian   +7 more
doaj   +1 more source

Classification, function, and advances in tsRNA in non-neoplastic diseases

Cell Death & Disease, 2023
AbstracttRNA-derived small RNAs (tsRNAs) are non-coding small RNAs produced by specific endonucleases following the processing and splicing of precursor or mature tRNAs upon starvation, oxidative stress, hypoxia, and other adverse conditions. tRNAs are classified into two major categories, tRNA fragments (tRFs) and tRNA-derived stress-induced small ...
Liou Zhang, Jie Liu, Yang Hou
openaire   +3 more sources