Results 11 to 20 of about 1,573 (166)

tsRNA in head and neck tumors: Opportunities and challenges in the field

Non-coding RNA Research
Transfer RNA-derived small RNAs (tsRNAs) are a newly recognized class of small non-coding RNAs that are implicated in a variety of cancers, including head and neck tumors.
Zhuo wu, Yufeng Xu, Changzeng Zhou, Yongbo Zhang, Jingjing Chen   +4 more
doaj   +3 more sources

tsRNA, cell death and disease: Connecting the dots

Non-coding RNA Research
Cell death is essential for maintaining physiological homeostasis and regulating pathological processes. tRNA-derived small RNAs (tsRNAs), an emerging non-coding small RNA, play key roles in a various form of cell death.
Xiaoyu Ma, Jiesi Xu, Guoping Li
doaj   +3 more sources

Diagnostic and prognostic values of tsRNAs in lung cancer: a meta-analysis

BMC Cancer, 2023
Background Lung cancer (LC) is the leading cause of cancer-related death in humans. tRNA-derived small RNA (tsRNA) is a novel biomarker that plays a crucial role in the genesis and development of LC.
Cheng Tang, Su-Xia Sun, Chao Gu, Chao-Juan Li, Jin Xu, Ke-Lei Su, Dan-Dan Zhou, Kuai Yu, Qing-Ling Xiao, Xiao-Li Chen   +9 more
doaj   +3 more sources

Research progress of tsRNAs in kidney diseases. [PDF]

PeerJ
Transfer RNA-derived small RNAs (tsRNAs) are a class of regulatory non-coding RNAs generated through enzymatic cleavage of precursor or mature tRNAs. In recent years, tsRNAs have garnered growing interest in nephrology due to their diverse biological functions and potential clinical significance.
Wang J, Wang Y, Li F, Xie X, Chen X, Wu T, Wang X.   +6 more
europepmc   +3 more sources

Biogenesis, function, and landscape of tsRNAs in central nervous system diseases

Clinical and Translational Discovery, 2023
Transfer RNA‐derived small RNAs (tsRNAs) are fragments that originate from mature or precursor tRNAs and are a subclass of sRNAs. With the development of high‐throughput sequencing techniques, the real feature of tsRNAs has gradually been revealed ...
Kaiying Yang, Yu Sun, Jie Zhao, Chang He, Xudong Pan, Xiaoyan Zhu   +5 more
doaj   +1 more source

tRNA-Derived Small RNAs: A Novel Regulatory Small Noncoding RNA in Renal Diseases

Kidney Diseases, 2023
Background: tRNA-derived small RNAs (tsRNAs) are an emerging class of small noncoding RNAs derived from tRNA cleavage. Summary: With the development of high-throughput sequencing, various biological roles of tsRNAs have been gradually revealed, including
Dan Li, Xian Xie, Ni Yin, Xueqin Wu, Bin Yi, Hao Zhang, Wei Zhang   +6 more
doaj   +1 more source

Biological functions of tsRNAs and research advances in human disease. [PDF]

Biochem Biophys Rep
tsRNAs (tRNA-derived small RNAs) are a class of noncoding small RNAs generated by nuclease-specific cleavage of mature tRNAs or their precursors. Since their functional discovery in 2009, tsRNAs have emerged as a research hotspot in molecular biology and medicine because of their unique generation mechanism, tissue-specific expression patterns, and ...
Jiang Y, Liu S, Li G, Tang C, Zhang Y, Li J, Tan Z, Zhang S, Chen Z, Li S.   +9 more
europepmc   +3 more sources

tsRNA signatures in cancer [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance We found that tRNA-derived small RNAs (tsRNAs) are dysregulated in many cancers and that their expression is modulated during cancer development and staging. Indeed, activation of oncogenes and inactivation of tumor suppressors lead to a dysregulation of specific tsRNAs, and tsRNA-KO cells display a ...
Veronica, Balatti, Giovanni, Nigita, Dario, Veneziano, Alessandra, Drusco, Gary S, Stein, Terri L, Messier, Nicholas H, Farina, Jane B, Lian, Luisa, Tomasello, Chang-Gong, Liu, Alexey, Palamarchuk, Jonathan R, Hart, Catherine, Bell, Mariantonia, Carosi, Edoardo, Pescarmona, Letizia, Perracchio, Maria, Diodoro, Andrea, Russo, Anna, Antenucci, Paolo, Visca, Antonio, Ciardi, Curtis C, Harris, Peter K, Vogt, Yuri, Pekarsky, Carlo M, Croce   +24 more
openaire   +2 more sources

Pathophysiological Significance of Neutrophilic Transfer RNA-Derived Small RNAs in Asymptomatic Moyamoya Disease

Cells, 2021
Understanding asymptomatic moyamoya disease (aMMD), for which treatment options are currently limited, is key to the development of therapeutic strategies that will slow down the progression of this disease, as well as facilitate the discovery of ...
Lingzhi Li, Ping Liu, Rongliang Wang, Yuyou Huang, Jichang Luo, Liqun Jiao, Zhen Tao, Yangmin Zheng, Junfen Fan, Haiping Zhao, Ziping Han, Yumin Luo   +11 more
doaj   +1 more source

Sperm tsRNAs and acquired metabolic disorders [PDF]

Journal of Endocrinology, 2016
Many findings support the hypothesis that metabolic changes associated with environmental factors can be transmitted from father to offspring. The molecular mechanisms underlying the intergenerational transmission of metabolic changes remain to be fully explored.
Menghong, Yan, Qiwei, Zhai
openaire   +2 more sources