Results 51 to 60 of about 24,896 (176)

Confirmation and distribution of tetrodotoxin for the first time in terrestrial invertebrates: two terrestrial flatworm species (Bipalium adventitium and Bipalium kewense). [PDF]

PLoS ONE, 2014
The potent neurotoxin tetrodotoxin (TTX) is known from a diverse array of taxa, but is unknown in terrestrial invertebrates. Tetrodotoxin is a low molecular weight compound that acts by blocking voltage-gated sodium channels, inducing paralysis. However,
Amber N Stokes, Peter K Ducey, Lorin Neuman-Lee, Charles T Hanifin, Susannah S French, Michael E Pfrender, Edmund D Brodie, Edmund D Brodie   +7 more
doaj   +1 more source

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Acute Toxicity Assessment: Macroscopic and Ultrastructural Effects in Mice Treated with Oral Tetrodotoxin

Toxins, 2019
Tetrodotoxin (TTX) is an extremely toxic marine compound produced by different genera of bacteria that can reach humans through ingestion mainly of pufferfish but also of other contaminated fish species, marine gastropods or bivalves.
Paula Abal, M. Carmen Louzao, Natalia Vilariño, Mercedes R. Vieytes, Luis M. Botana   +4 more
doaj   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Oral Chronic Toxicity of the Safe Tetrodotoxin Dose Proposed by the European Food Safety Authority and Its Additive Effect with Saxitoxin

Toxins, 2020
Tetrodotoxin (TTX) is a potent natural toxin causative of human food intoxications that shares its mechanism of action with the paralytic shellfish toxin saxitoxin (STX). Both toxins act as potent blockers of voltage-gated sodium channels. Although human
Andrea Boente-Juncal, Paz Otero, Inés Rodríguez, Mercedes Camiña, Mercedes Rodriguez-Vieytes, Carmen Vale, Luis M. Botana   +6 more
doaj   +1 more source

A Probability‐Aware AI Framework for Reliable Anti‐Jamming Communication

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Adversarial jamming attacks have increased on communication systems, causing distortion and threatening transmissions. Typical attacks rely on traditional, well‐defined cryptographic protocols and frequency‐hopping techniques. Nevertheless, these techniques become vulnerable when facing intelligent jammers.
Tawfeeq Shawly, Ahmed A. Alsheikhy
wiley   +1 more source

The oscillatory response of the electroretinogram and neuronal adaptation

Acta Ophthalmologica, EarlyView.
Abstract After more than 50 years, there still remains a challenge and an interest to know more as well as extend and deepen our understanding of the small rapid wavelets, the oscillatory potentials (OPs), of the electroretinogram (ERG) and the neuronal adaptation of the retina.
Lillemor Wachtmeister, Anders Eklund
wiley   +1 more source

Lactic acid bacteria reduce the toxicity of tetrodotoxin through peptidoglycan mediated binding

Aquaculture and Fisheries
Tetrodotoxin (TTX) is a potent neurotoxin found in nature, the possible presence of TTX in pufferfish ovaries, liver, and other processing waste poses a serious environmental and safety hazard.
Chang Liu, Jingqin Ye, Chang'e Wang, Hengliang Wang, Ying Lu   +4 more
doaj   +1 more source

Behavioral and Chemical Ecology of Marine Organisms with Respect to Tetrodotoxin

Marine Drugs, 2010
The behavioral and chemical ecology of marine organisms that possess tetrodotoxin (TTX) has not been comprehensively reviewed in one work to date. The evidence for TTX as an antipredator defense, as venom, as a sex pheromone, and as an attractant for TTX-
Becky L. Williams
doaj   +1 more source