Results 71 to 80 of about 24,896 (176)

The impact of tetrodotoxin (TTX) on the gut microbiome in juvenile tiger pufferfish, Takifugu rubripes

Scientific Reports
Tetrodotoxin (TTX) is a potent neurotoxin that accumulates in Takifugu rubripes, commonly known as pufferfish, through the ingestion of TTX-bearing organisms as part of their food chain.
Mai A. Wassel, Yoko Makabe-Kobayashi, Md Mehedi Iqbal, Tomohiro Takatani, Yoshitaka Sakakura, Koji Hamasaki   +5 more
doaj   +1 more source

Intracellular Immunohistochemical Detection of Tetrodotoxin in Pleurobranchaea maculata (Gastropoda) and Stylochoplana sp. (Turbellaria)

Marine Drugs, 2015
Tetrodotoxin (TTX), is a potent neurotoxin targeting sodium channels that has been identified in multiple marine and terrestrial organisms. It was recently detected in the Opisthobranch Pleurobranchaea maculata and a Platyhelminthes Stylochoplana sp ...
Lauren R. Salvitti, Susanna A. Wood, Leigh Winsor, Stephen Craig Cary   +3 more
doaj   +1 more source

Spatio‐Temporal Diversity of Calcium Activity in Microglia

Glia, Volume 74, Issue 3, March 2026.
Ca2+ activity mostly occurs in microglial processes and stays localized. When it spreads, it often shows a directional bias and is constrained by branch points. Activity strongly relies on P2Y12 receptors and is shaped by neuronal activity. ABSTRACT Microglia, the brain's innate immune cells, possess complex, highly motile branched processes. These act
Hiroshi Horiuchi, Dennis Lawrence Cheung, Junko Ishida, Junichi Nabekura   +3 more
wiley   +1 more source

Automated Patch Clamp for the Detection of Tetrodotoxin in Pufferfish Samples

Marine Drugs
Tetrodotoxin (TTX) is a marine toxin responsible for many intoxications around the world. Its presence in some pufferfish species and, as recently reported, in shellfish, poses a serious health concern. Although TTX is not routinely monitored, there is a
Mònica Campàs, Jaume Reverté, Àngels Tudó, Mounira Alkassar, Jorge Diogène, Francesc X. Sureda   +5 more
doaj   +1 more source

Fmr1 knockout disrupts multiple intrinsic properties via reduced HCN channel activity in mediodorsal thalamocortical neurons

Experimental Physiology, Volume 111, Issue 3, Page 1340-1364, 1 March 2026.
Abstract The neurodevelopmental disorder fragile X syndrome (FXS) results from hypermethylation of the FMR1 gene, which prevents production of the FMRP protein. FMRP modulates the expression and function of a variety of proteins, including voltage‐gated ion channels, such as hyperpolarization‐activated and cyclic nucleotide‐gated (HCN) channels, which ...
Gregory J. Ordemann, Polina Lyuboslavsky, Alena Kizimenko, Audrey C. Brumback   +3 more
wiley   +1 more source

Serendipitous compound action potential oscillations reveal glycolytic astrocyte and oxidative axon interstitial K+ buffering in central white matter

Experimental Physiology, Volume 111, Issue 3, Page 1313-1329, 1 March 2026.
Abstract The principal processes that govern interstitial K+ ([K+]o) buffering in mouse optic nerve (MON), a central white matter tract, either directly consume energy (Na+–K+‐ATPase) or use transmembrane ion gradients created by energy‐dependent pumps to enable the K+ fluxes that maintain a stable [K+]o, and thus ready availability of utilisable ...
Amy J. Hopper, Angus M. Brown
wiley   +1 more source

Tetrodotoxin: The State-of-the-Art Progress in Characterization, Detection, Biosynthesis, and Transport Enrichment

Marine Drugs
Tetrodotoxin (TTX) is a neurotoxin that binds to sodium channels and blocks sodium conduction. Importantly, TTX has been increasingly detected in edible aquatic organisms.
Xinxin Zhang, Kun Qiao, Ruimin Cui, Min Xu, Shuilin Cai, Qilin Huang, Zhiyu Liu   +6 more
doaj   +1 more source

Adaptive evolution of scn4aa in Takifugu and Tetraodon

Aquaculture and Fisheries
Tetrodotoxin (TTX) is a potent neurotoxin firstly discovered in the ovary of pufferfish. The genetic basis of voltage-gated sodium channel resistance to TTX has been widely studied, but it remains unclear in the evolution history of voltage-gated sodium ...
Hexing Wu, Yonglai Hu, Jing Wang, Xiaoling Gong, Baolong Bao   +4 more
doaj   +1 more source

Characterization of persistent TTX-R Na+ currents in physiological concentration of sodium in rat visceral afferents

International Journal of Biological Sciences, 2009
Persistent tetrodotoxin-resistant (TTX-R) Na+ (Nav1.9/SCN11A) currents are not normally recorded in vagal afferent neurons (VANs) with 50 mM of extracellular Na+ although the functional expression of this current was observed in the presence of PGE2 or ...
Guo-Fen Qiao, Bai-Yan Li, Yu-Hong Zhou, Yan-Jie Lu, John H. Schild
doaj  

Recent research progress in tetrodotoxin detection and quantitative analysis methods

Frontiers in Chemistry
Tetrodotoxin (TTX) is a highly potent and widely distributed ion-channel marine neurotoxin; it has no specific antidote and poses a great risk to human health.
Chao Lin, Qirong Li, Dong Liu, Qiang Feng, Hengzong Zhou, Bohe Shi, Xinxin Zhang, Yurui Hu, Xinmiao Jiang, Xiaoming Sun, Dongxu Wang   +10 more
doaj   +1 more source