Results 61 to 70 of about 1,231,953 (350)
New England Journal of Medicine, 2018 BACKGROUND A vaccine to interrupt the transmission of tuberculosis is needed. METHODS We conducted a randomized, double‐blind, placebo‐controlled, phase 2b trial of the M72/AS01E tuberculosis vaccine in Kenya, South Africa, and Zambia.
Olivier Van Der Meeren +25 more
semanticscholar +1 more source
PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC
Advanced Science, EarlyView.CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao +16 more
wiley +1 more source
MicroRNAs as fibrosis markers in patients with hypersensitivity pneumonitis
Медицинская иммунологияHypersensitivity pneumonitis (HP) is a complex interstitial pulmonary syndrome. This clinical entity is characterized by sensitization to a specific antigen.
G. S. Shepelkova +5 more
doaj +1 more source
Four Months of Rifampin or Nine Months of Isoniazid for Latent Tuberculosis in Adults
New England Journal of Medicine, 2018 BACKGROUND A 9‐month regimen of isoniazid can prevent active tuberculosis in persons with latent tuberculosis infection. However, the regimen has been associated with poor adherence rates and with toxic effects.
D. Menzies +28 more
semanticscholar +1 more source
Advanced Science, EarlyView.Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen +22 more
wiley +1 more source
Valve bronchial block in the integrated treatment of respiratory tuberculosis in the adolescent
Туберкулез и болезни лёгких, 2016 Goal: The clinical case is presented to describe the successful use of valve bronchial block (installation endobronchial valve into the bronchus) for treatment of cavities in the 15 year old female adolescent with bilateral pulmonary tuberculosis.Results.
E. S. Ovsyankina +4 more
doaj +1 more source
Advanced Science, EarlyView.BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang +9 more
wiley +1 more source
Advanced Science, EarlyView.Corticosteroids improve the efficacy of immune checkpoint blockade therapy in metastatic murine breast cancer. By normalizing the tumor immune microenvironment, corticosteroids reduce immunosuppressive signals, restore T‐cell function, and promote antitumor immune responses, resulting in enhanced tumor control.
John D. Martin +19 more
wiley +1 more source
Advanced Science, EarlyView.ImmuDef, a novel algorithm to quantitatively evaluate the anti‐infection immune defense function of an individual based on RNA‐seq data via a variational autoencoder (VAE) model. It is validated on 3200+ samples across four immune states with high accuracy. It can serve as a metric for disease severity and prognosis across pathogenic cohorts.
Zhen‐Lin Tan +7 more
wiley +1 more source