Results 61 to 70 of about 1,229,168 (350)

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Phase 2b placebo-controlled trial of M72/AS01E candidate vaccine to prevent active tuberculosis in adults

New England Journal of Medicine, 2018
BACKGROUND A vaccine to interrupt the transmission of tuberculosis is needed. METHODS We conducted a randomized, double‐blind, placebo‐controlled, phase 2b trial of the M72/AS01E tuberculosis vaccine in Kenya, South Africa, and Zambia.
Olivier Van Der Meeren, M. Hatherill, V. Nduba, R. Wilkinson, M. Muyoyeta, Elana van Brakel, H. Ayles, G. Henostroza, F. Thienemann, T. Scriba, A. Diacon, G. Blatner, M. Demoitié, M. Tameris, M. Malahleha, J. Innes, Elizabeth Hellström, N. Martinson, T. Singh, E. J. Akité, Aisha Khatoon Azam, A. Bollaerts, A. Ginsberg, T. Evans, P. Gillard, D. Tait   +25 more
semanticscholar   +1 more source

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source

Four Months of Rifampin or Nine Months of Isoniazid for Latent Tuberculosis in Adults

New England Journal of Medicine, 2018
BACKGROUND A 9‐month regimen of isoniazid can prevent active tuberculosis in persons with latent tuberculosis infection. However, the regimen has been associated with poor adherence rates and with toxic effects.
D. Menzies, M. Adjobimey, R. Ruslami, A. Trajman, O. Sow, H. Kim, J. Baah, G. Marks, R. Long, V. Hoeppner, K. Elwood, H. Al-Jahdali, M. Gninafon, L. Apriani, R. Koesoemadinata, A. Kritski, V. Rolla, B. Bah, A. Camara, I. Boakye, V. Cook, H. Goldberg, C. Valiquette, K. Hornby, M. Dion, P. Li, P. Hill, K. Schwartzman, A. Benedetti   +28 more
semanticscholar   +1 more source

Antiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer

Advanced Science, EarlyView.
Corticosteroids improve the efficacy of immune checkpoint blockade therapy in metastatic murine breast cancer. By normalizing the tumor immune microenvironment, corticosteroids reduce immunosuppressive signals, restore T‐cell function, and promote antitumor immune responses, resulting in enhanced tumor control.
John D. Martin, Koji Nagaoka, Myrofora Panagi, Akihiro Hosoi, Fotios Mpkeris, Pengwen Chen, Thahomina T. Khan, Margaret R. Martin, Changbo Sun, Chrysovalantis Voutouri, Maria Louca, Panagiotis Papageorgis, Akira Sumiyoshi, Nobuhiro Nitta, Kazuyoshi Takeda, Ichio Aoki, Kazunori Kataoka, Triantafyllos Stylianopoulos, Kazuhiro Kakimi, Horacio Cabral   +19 more
wiley   +1 more source

Tuberculosis [PDF]

Clinical Medicine, 2008
Anna, Goodman, Marc, Lipman
openaire   +5 more sources

Spatiotemporally Controlled Tumor Photodynamic/Immunotherapy Therapy Based on Upconversion Hybrid Nanosystem

Advanced Science, EarlyView.
PURH is constructed by a five‐layer upconversion nanoparticle (UCNP) surface coated with mesoporous silica, which encapsulates rose bengal (RB) within the mesoporous channels. Additionally, CpG oligonucleotides (CpG ODN) is linked to the surface, followed by the surface functionalization of hyaluronic acid (HA). This spatiotemporally controllable smart
Fang Wang, Wenfei Xu, Yuechen Liu, Shuxuan Zhu, Wenjing Liu, Shuhui Bo, Hong Sun, Bei Liu, Zhaogang Sun, Hongqian Chu   +9 more
wiley   +1 more source

Bench‐Stable Boryl Thianthrenium Dication Enables Aziridinyl Boronate Synthesis via Metal‐Free Late‐Stage Aziridination with Diverse Nitrogen Nucleophiles

Angewandte Chemie, EarlyView.
A bench‐stable boryl thianthrenium dication is synthesized via thianthrenation of vinyl MIDA boronate. This novel dication enables metal‐free, chemo‐, and diastereoselective late‐stage aziridination with diverse nitrogen nucleophiles. The strategic significance is further showcased by one‐pot electrochemical and asymmetric protocols and versatile ...
Veerabhadra R. Vulupala, Disni Gunasekera, Nagarjun R. Mallampudi, Ramy Yousef, Yusif I. Gyasi, Gopal R. Ramidi, Ifeoluwa Adedotun, Shiqing Xu   +7 more
wiley   +2 more sources

Valve bronchial block in the integrated treatment of respiratory tuberculosis in the adolescent

Туберкулез и болезни лёгких, 2016
Goal: The clinical case is presented to describe the successful use of valve bronchial block (installation endobronchial valve into the bronchus) for treatment of cavities in the 15 year old female adolescent with bilateral pulmonary tuberculosis.Results.
E. S. Ovsyankina, O. V. Lovacheva, L. V. Panova, A. Yu. Khiteva, F. A. Poluehktov   +4 more
doaj   +1 more source

Policy changes and the screening, diagnosis and treatment of drug-resistant tuberculosis patients from 2015 to 2018 in Zhejiang Province, China: a retrospective cohort study [PDF]

, 2021
Weixi Jiang, Ying Peng, Xiaomeng Wang, Chris Elbers, Shenglan Tang, Fei Huang, Bin Chen, Frank Cobelens   +7 more
openalex   +1 more source