Results 61 to 70 of about 769,512 (313)
H2S Is a Potential Universal Reducing Agent for Prx6‐Type Peroxiredoxins
Advanced Science, EarlyView.We report the identification of H2S as reducing agent for Prx6‐type peroxiredoxins. In contrast to common physiological reducing agents of other peroxiredoxins, HS− is small enough to access the active site of oxidized Prx6‐type enzymes in the fully‐folded protein conformation.
Lukas Lang +3 more
wiley +1 more source
Valve bronchial block in the integrated treatment of respiratory tuberculosis in the adolescent
Туберкулез и болезни лёгких, 2016 Goal: The clinical case is presented to describe the successful use of valve bronchial block (installation endobronchial valve into the bronchus) for treatment of cavities in the 15 year old female adolescent with bilateral pulmonary tuberculosis.Results.
E. S. Ovsyankina +4 more
doaj +1 more source
Advanced Science, EarlyView.KPPepGen is a knowledge‐aware prompt diffusion model for the controllable generation of pathogen‐specific AMPs. It outperforms existing methods and is capable of simultaneously generating peptides for distinct pathogens, demonstrating superior performance with favorable properties and docking efficacy.
Yongkang Wang +4 more
wiley +1 more source
Медицинская иммунологияYB-1 is a multifunctional protein, being a transcription factor involved in the regulation of numerous cellular processes. YB-1 is an important factor in molecular cascades that regulate the response to the pathogen invasion, inflammatory activity, as ...
M. V. Erokhina +6 more
doaj +1 more source
Advanced Science, EarlyView.Integrin αvβ6‐targeted [68Ga]Ga‐Trivehexin positron emission tomography/computed tomography (PET/CT) can accurately identify regional lymph nodes and cerebral metastases in non‐small cell lung cancer (NSCLC) compared with 2‐deoxy‐2‐[18F]fluoro‐D‐glucose ([18F]FDG).
Huiqin Wu +9 more
wiley +1 more source
Advanced Science, EarlyView.Single‐cell transcriptomics and clinical data show that during myasthenia gravis (MG) exacerbation, bone marrow mature neutrophils expand and enter blood, with parallel increase of B‐cell activating factor (BAFF)–positive neutrophils. Experimental autoimmune myasthenia gravis (EAMG) confirms a pathogenic interferon‐γ (IFN‐γ)–neutrophil–BAFF axis ...
Zhaoxu Zhang +5 more
wiley +1 more source
Biomedical Applications of Nanozymes: An Enzymology Perspective
Angewandte Chemie, EarlyView.With a lens of enzymology, this review compares nanozymes with enzymes using the Michaelis‐Menten model and differences in KM and kcat along with catalysis in complex biological environment. The implications of these differences in biomedical applications of nanozymes are then described with a statistical analysis of the trend of therapeutic use of ...
Vasily G. Panferov +4 more
wiley +2 more sources
Adverse reactions in the treatment of patients with non-tuberculous lung mycobacterial pulmonary disease and the possibility of their solution [PDF]
Терапевтический архивAim. To study the adverse reactions that develop as a result of complex antibiotic therapy in patients with non-tuberculous lung mycobacterial (NTML) and to determine methods for their elimination without compromising the effectiveness of NTML treatment.
Elena B. Vladimirova +6 more
doaj +1 more source
Advanced Science, EarlyView.Punicalagin, a pomegranate molecule, helps the body fight Mycobacterium abscessus. It preferentially boosts interstitial macrophages in the lung, stabilizing mitochondria and switching on the autophagy via SIRT1/FoxO3a, which lowers bacterial load without directly killing bacteria.
Kefan Bi +4 more
wiley +1 more source