Results 71 to 80 of about 1,229,168 (350)

A Deep Representation Learning Method for Quantitative Immune Defense Function Evaluation and Its Clinical Applications

Advanced Science, EarlyView.
ImmuDef, a novel algorithm to quantitatively evaluate the anti‐infection immune defense function of an individual based on RNA‐seq data via a variational autoencoder (VAE) model. It is validated on 3200+ samples across four immune states with high accuracy. It can serve as a metric for disease severity and prognosis across pathogenic cohorts.
Zhen‐Lin Tan, Tao Luo, Yu Lin, Xiao‐Jun Wu, Wen‐Kang Shen, Jie Chen, Qian Lei, An‐Yuan Guo   +7 more
wiley   +1 more source

MicroRNAs as fibrosis markers in patients with hypersensitivity pneumonitis

Медицинская иммунология
Hypersensitivity pneumonitis (HP) is a complex interstitial pulmonary syndrome. This clinical entity is characterized by sensitization to a specific antigen.
G. S. Shepelkova, A. S. Zaytseva, V. V. Evstifeev, E. N. Adamovskaya, E. I. Shmelev, V. V. Yeremeev   +5 more
doaj   +1 more source

Artificial Intelligence‐Driven Soft Bioelectronics for Self‐Powered Respiration Monitoring

Advanced Science, EarlyView.
Artificial intelligence‐driven soft bioelectronics for self powered respiration monitoring based on triboelectric nanogenerators (TENGs), piezoelectric nanogenerators (PENGs), and magnetoelastic generators (MEGs) enable continuous and multi‐scenario respiratory biomechanical data collection. Coupled with machine learning and big data driven diagnostics,
Xinkai Xu, Xiao Xiao, Rui Guo, Jun Chen
wiley   +1 more source

AI‐Assisted Bioelectronics for Personalized Health Management

Advanced Electronic Materials, EarlyView.
Recent advances in artificial intelligence (AI)‐assisted bioelectronics, including materials, device fabrication, working mechanisms, AI‐hardware integration, and proof‐of‐concept applications in digital health management, are summarized. The emergence of AI‐assisted bioelectronic systems and potential solutions to existing challenges are discussed ...
Huiwen Xiong, Changhao Dai, Xuting Chen, Jilie Kong, Dacheng Wei, Xueen Fang, Wenhao Weng   +6 more
wiley   +1 more source

X-RAY MORPHOLOGICAL SEMIOTICS OF NON-TUBERCULOUS MYCOBACTERIAL PULMONARY DISEASE

Вестник рентгенологии и радиологии, 2018
Objective: to evaluate the X-ray radiological features of nontuberculous mycobacterial pulmonary disease (NTMPD) versus morphological findings.Material and methods.
R. B. Amansakhedov, L. N. Lepekha, L. I. Dmitrieva, I. Yu. Andrievskaya, A. T. Sigaev, N. N. Makar’yants, V. V. Romanov, A. E. Ergeshov   +7 more
doaj   +1 more source

Tuberculosis following PD-1 blockade for cancer immunotherapy

Science Translational Medicine, 2019
Increased Mtb-specific TH1 responses precede tuberculosis associated with PD-1 blockade. Preaching caution with PD-1 blockade for TB Scientists are interested in leveraging PD-1 blockade for diseases other than cancer, such as tuberculosis (TB).
Daniel L. Barber, Shunsuke Sakai, R. Kudchadkar, S. Fling, T. Day, Julie A Vergara, D. Ashkin, Jonathan H Cheng, Lisa M Lundgren, V. Raabe, C. Kraft, J. Nieva, M. Cheever, P. Nghiem, E. Sharon   +14 more
semanticscholar   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Construction and Validation of a Nomogram-Based Predictive Model for Acute Kidney Injury Caused by Drug Resistance to Tuberculosis

International Journal of General Medicine
Mo Deng,* Na Han, Mishan Jia, Zhiqing Zheng, Yanqing Tian, Hui Wang,* Li Feng Department of Tuberculosis, Affiliated Hospital of Hebei University, Baoding, Hebei, 071000, People’s Republic of China*These authors contributed ...
Deng M, Han N, Jia M, Zheng Z, Tian Y, Wang H, Feng L   +6 more
doaj  

Correlations between expression levels of genes encoding multifunctional YB-1 protein, inflammatory cytokines and multidrug resistance P-gp protein in surgical material from patients with lung tuberculosis

Медицинская иммунология
YB-1 is a multifunctional protein, being a transcription factor involved in the regulation of numerous cellular processes. YB-1 is an important factor in molecular cascades that regulate the response to the pathogen invasion, inflammatory activity, as ...
M. V. Erokhina, E. N. Pavlova, E. A. Scherbakova, E. Yu. Rybalkina, L. N. Lepekha, R. V. Tarasov, E. K. Tarasova   +6 more
doaj   +1 more source

Is Mycobacterium tuberculosis infection life long?

British medical journal, 2019
People with immunoreactivity to tuberculosis are thought to have lifelong asymptomatic infection and remain at risk for active tuberculosis.
M. Behr, P. Edelstein, L. Ramakrishnan
semanticscholar   +1 more source