Results 101 to 110 of about 47,249 (313)

Bedaquiline Resistance after Effective Treatment of Multidrug-Resistant Tuberculosis, Namibia

Emerging Infectious Diseases
Bedaquiline is currently a key drug for treating multidrug-resistant or rifampin-resistant tuberculosis. We report and discuss the unusual development of resistance to bedaquiline in a teenager in Namibia, despite an optimal background regimen and ...
Gunar Günther, Lusia Mhuulu, Azaria Diergaardt, Viola Dreyer, Maria Moses, Kaarna Anyolo, Nunurai Ruswa, Mareli Claassens, Stefan Niemann, Emmanuel Nepolo   +9 more
doaj   +1 more source

Increased Plasma Microbial tDR‐1 in At‐Risk Individuals Is Associated With Decreased Conversion to Clinical Rheumatoid Arthritis and Reduces an In Vitro Macrophage Type 1 Interferon Response

Arthritis &Rheumatology, EarlyView.
Objective Microbial small RNAs can regulate human genes. Higher plasma concentrations of microbial transfer RNA (tRNA)‐derived RNA‐1 (tDR‐1) were previously associated with lower rheumatoid arthritis (RA) disease activity. This study examined whether tDR‐1 concentrations differ in anticyclic citrullinated peptide‐3 positive (CCP3+) at‐risk individuals (
Anastasiia Phothisane, Tulsi K. Joishy, Carolina Ramirez‐Becerra, Qiong Wu, Jennifer Seifert, Marie L. Feser, Jill M. Norris, M. Kristen Demoruelle, LauraKay Moss, Kevin D. Deane, V. Michael Holers, Michelle J. Ormseth   +11 more
wiley   +1 more source

Protein identification and tracking in two-dimensional electrophoretic gels by minimal protein identifiers. [PDF]

, 2004
Protein identification by matrix-assisted laser desorption/ionization mass-spectrometry peptide mass fingerprinting (MALDI-MS PMF) represents a cornerstone of proteomics. However, it often fails to identify low-molecular-mass proteins, protein fragments,
Jens Mattow, Schmidt, Frank, Kaufmann, Stefan H. E., Hoehenwarter, Wolfgang, Frank Schmidt, Mattow, Jens, Kaufmann, Stefan HE, Ulrich E. Schaible, Frank Siejak, Schaible, Ulrich E, Wolfgang Höhenwarter, Höhenwarter, Wolfgang, Schaible, Ulrich E., Siejak, Frank, Stefan H.E. Kaufmann   +14 more
core   +1 more source

MT‐RNR1 genotype testing for preventing aminoglycoside‐mediated ototoxicity: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, EarlyView.
Aminoglycosides are broad‐spectrum antibiotics used in the management of severe infections. Aminoglycosides are associated with nephrotoxicity and ototoxicity. Although dosing strategies such as once‐daily administration and therapeutic drug monitoring have reduced the incidence of nephrotoxicity, ototoxicity remains unpredictable and may occur at ...
John H. McDermott, Sian Hilton, Cinzia Dello Russo, Nicola Booth, Simon Drysdale, Philip Howard, Stephen Hughes, Mallinath Chakraborty, Helen McDevitt, Charlotte Alston, Maya Desai, Mike Beadsworth, Adam Reynolds, Serim Min, Katherine Payne, Munir Pirmohamed, William G. Newman   +16 more
wiley   +1 more source

Comparative analysis of Mycobacterium tuberculosis pe and ppe genes reveals high sequence variation and an apparent absence of selective constraints. [PDF]

, 2012
Contains fulltext : 110619.pdf (Publisher’s version ) (Open Access)Mycobacterium tuberculosis complex (MTBC) genomes contain 2 large gene families termed pe and ppe.
Nicolaas C. Gey van Pittius (173264), McEvoy, CRE, Paul D. van Helden (33594), Warren Robin M., Gagneux, Sebastien, Schurch, A. C., Nicolaas C Gey van Pittius, Robin M Warren, van Helden, PD, Anita C. Schürch (173257), Schurch, Anita C., van Helden, P. D., Cloete, Ruben, Ruben Cloete, Borna Müller, Paul D van Helden, Muller, B., Cloete, R, Geyvan Pittius, N.C., Warren, RM, McEvoy, C.R., Schürch, AC, Schürch Anita C., Warren, R. M., Gey van Pittius, NC, Gey van Pittius, Nicolaas C., Christopher R E McEvoy, Müller, B, Gagneux, S., Helden, P.D. van, Müller Borna, Cloete, R., Borna Müller (173253), Warren, R.M., Gagneux Sebastien, Muller, Borna, Anita C Schürch, Gey van Pittius, N. C., Warren, Robin M., McEvoy, Christopher R. E., McEvoy Christopher R. E., Gey van Pittius Nicolaas C., Christopher R. E. McEvoy (173247), Sebastien Gagneux (149824), McEvoy, C. R., Ruben Cloete (173249), van Helden Paul D., Gagneux, S, Sebastien Gagneux, Schurch, A.C., Van Helden, Paul D., Robin M. Warren (33593), Cloete Ruben   +52 more
core   +1 more source

Enhancing the Secretion Systems: Genetic Engineering of Super Bioagents for Effective Plant Disease Control

Biotechnology and Bioengineering, EarlyView.
Genetic engineering (GE) overcomes BCA limits, enabling robust, scalable crop protection. “Super Bioagents” (SBs) use optimized SSs to enhance bioactive molecule delivery. Optimizing SSs enhance precise, sustainable effector deployment for stable disease suppression. SBs use microbiome‐informed design for scalable, next‐gen sustainable crop protection.
Michael Dare Asemoloye
wiley   +1 more source

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

DNA probes for mycobacteria. I. Isolation of DNA probes for the identification of Mycobacterium tuberculosis complex and for mycobacteria other than tuberculosis (MOTT).

Molecular and cellular probes, 1988
Traditional methods used in identifying mycobacteria such as acid-fast bacillus stains and culture are often time-consuming, insensitive and non-specific. The isolation of DNA probes, coupled to a non-radioactive, e.g. biotin-based detection system, have the potential to foster the development of clinical assays for Mycobacterium tuberculosis and ...
Picken, R. N., Plotch, S. J., Wang, Z., Lin, B. C., Donegan, J. J., Yang, Huey-Lang   +5 more
openaire   +2 more sources

Enhanced strategies for cuproptosis‐like death in bacterial infection treatment

BMEMat, EarlyView.
This review summarizes and examines the molecular mechanisms underlying cuproptosis‐like death. Furthermore, multi‐strategy efficacy enhancement and potential enhancement approaches are analyzed. Abstract Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications.
Wenqi Wang, Bolong Xu, Ruiyuan Zhu, Hengshuo Gui, Tian Xia, Shaokai Liu, Huiyu Liu, Xianwen Wang   +7 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source