Results 1 to 10 of about 293,904 (334)
Cells, 2021 Members of the tubulin superfamily are GTPases; the activities of GTPases are necessary for life. The members of the tubulin superfamily are the constituents of the microtubules and the γ-tubulin meshwork.
Maria Alvarado Kristensson
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Recent Advances of Tubulin Inhibitors Targeting the Colchicine Binding Site for Cancer Therapy
Biomolecules, 2022 Cancer accounts for numerous deaths each year, and it is one of the most common causes of death worldwide, despite many breakthroughs in the discovery of novel anticancer candidates.
Mohammed Hawash
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Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy
Molecules, 2017 Antibody-drug conjugates (ADCs) are a class of highly potent biopharmaceutical drugs generated by conjugating cytotoxic drugs with specific monoclonal antibodies through appropriate linkers.
Zongtao Lin, Duane D Miller, Wei Li
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The tubulin code and its role in controlling microtubule properties and functions
Nature Reviews Molecular Cell Biology, 2020 Carsten Janke, Maria M Magiera
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An Emerging Role for Tubulin Isotypes in Modulating Cancer Biology and Chemotherapy Resistance
International Journal of Molecular Sciences, 2017 Tubulin proteins, as components of the microtubule cytoskeleton perform critical cellular functions throughout all phases of the cell cycle. Altered tubulin isotype composition of microtubules is emerging as a feature of aggressive and treatment ...
Joshua A Mccarroll, Maria Kavallaris
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Tubulin Inhibitors Targeting the Colchicine Binding Site: A Perspective of Privileged Structures
Future Medicinal Chemistry, 2017 The vital roles of microtubule in mitosis and cell division make it an attractive target for antitumor therapy. Colchicine binding site of tubulin is one of the most important pockets that have been focused on to design tubulin-destabilizing agents. Over
Shengtao Xu, Zheying Zhu
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Microtubule nucleation by γ-tubulin complexes
Nature Reviews Molecular Cell Biology, 2011 Justin M Kollman +2 more
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Frontiers in Cell and Developmental Biology, 2022 Microtubules are cytoskeletal filaments underlying the morphology and functions of all eukaryotic cells. In higher eukaryotes, the basic building blocks of these non-covalent polymers, ɑ- and β-tubulins, are encoded by expanded tubulin family genes (i.e.,
Shih-Chieh Ti
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eLife, 2021 Hydrolysis of nucleoside triphosphates releases similar amounts of energy. However, ATP hydrolysis is typically used for energy-intensive reactions, whereas GTP hydrolysis typically functions as a switch.
Taylor B Updegrove +11 more
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