Results 1 to 10 of about 50,223 (97)

Recent Advances of Tubulin Inhibitors Targeting the Colchicine Binding Site for Cancer Therapy

Biomolecules, 2022
Cancer accounts for numerous deaths each year, and it is one of the most common causes of death worldwide, despite many breakthroughs in the discovery of novel anticancer candidates.
Mohammed Hawash
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Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics

eLife, 2015
Microtubule dynamics and polarity stem from the polymerization of αβ-tubulin heterodimers. Five conserved tubulin cofactors/chaperones and the Arl2 GTPase regulate α- and β-tubulin assembly into heterodimers and maintain the soluble tubulin pool in the ...
Stanley Nithianantham, Sinh Le, Elbert Seto, Weitao Jia, Julie Leary, Kevin D Corbett, Jeffrey K Moore, Jawdat Al-Bassam   +7 more
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Novel Natural Product- and Privileged Scaffold-Based Tubulin Inhibitors Targeting the Colchicine Binding Site

Molecules, 2016
Tubulin inhibitors are effective anticancer agents, however, there are many limitations to the use of available tubulin inhibitors in the clinic, such as multidrug resistance, severe side-effects, and generally poor bioavailability.
Mengqi Dong, Fang Liu, Hongyu Zhou, Shumei Zhai, Bing Yan   +4 more
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The Game of Tubulins

Cells, 2021
Members of the tubulin superfamily are GTPases; the activities of GTPases are necessary for life. The members of the tubulin superfamily are the constituents of the microtubules and the γ-tubulin meshwork.
Maria Alvarado Kristensson
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Reconstituting Microtubules: A Decades-Long Effort From Building Block Identification to the Generation of Recombinant α/β-Tubulin

Frontiers in Cell and Developmental Biology, 2022
Microtubules are cytoskeletal filaments underlying the morphology and functions of all eukaryotic cells. In higher eukaryotes, the basic building blocks of these non-covalent polymers, ɑ- and β-tubulins, are encoded by expanded tubulin family genes (i.e.,
Shih-Chieh Ti
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Crosstalk between acetylation and the tyrosination/detyrosination cycle of α-tubulin in Alzheimer’s disease

Frontiers in Cell and Developmental Biology, 2022
Microtubules (MTs) support a variety of neuronal functions, such as maintenance of cell structure, transport, and synaptic plasticity. Neuronal MTs are highly heterogeneous due to several tubulin isotypes and the presence of multiple post-translational ...
José Martínez-Hernández, Julie Parato, Julie Parato, Aditi Sharma, Jean-Marc Soleilhac, Xiaoyi Qu, Ellen Tein, Andrew Sproul, Andrew Sproul, Annie Andrieux, Yves Goldberg, Marie-Jo Moutin, Francesca Bartolini, Leticia Peris   +13 more
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Identification of Inhibitors of Tubulin Polymerization Using a CRISPR-Edited Cell Line with Endogenous Fluorescent Tagging of β-Tubulin and Histone H1

Biomolecules, 2023
Tubulin is a protein that plays a critical role in maintaining cellular structure and facilitating cell division. Inhibiting tubulin polymerization has been shown to be an effective strategy for inhibiting the proliferation of cancer cells.
Harutyun Khachatryan, Bartlomiej Olszowy, Carlos A. Barrero, John Gordon, Oscar Perez-Leal   +4 more
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Mechanistic Analysis of CCP1 in Generating ΔC2 α-Tubulin in Mammalian Cells and Photoreceptor Neurons

Biomolecules, 2023
An important post-translational modification (PTM) of α-tubulin is the removal of amino acids from its C-terminus. Removal of the C-terminal tyrosine residue yields detyrosinated α-tubulin, and subsequent removal of the penultimate glutamate residue ...
Takashi Hotta, Alexandra Plemmons, Margo Gebbie, Trevor A. Ziehm, Teresa Lynne Blasius, Craig Johnson, Kristen J. Verhey, Jillian N. Pearring, Ryoma Ohi   +8 more
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γ-Tubulin Complexes and Fibrillar Arrays: Two Conserved High Molecular Forms with Many Cellular Functions

Cells, 2021
Higher plants represent a large group of eukaryotes where centrosomes are absent. The functions of γ-tubulin small complexes (γ-TuSCs) and γ-tubulin ring complexes (γ-TuRCs) in metazoans and fungi in microtubule nucleation are well established and the ...
Jana Chumová, Hana Kourová, Lucie Trögelová, Geoffrey Daniel, Pavla Binarová   +4 more
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Reformulation of an extant ATPase active site to mimic ancestral GTPase activity reveals a nucleotide base requirement for function

eLife, 2021
Hydrolysis of nucleoside triphosphates releases similar amounts of energy. However, ATP hydrolysis is typically used for energy-intensive reactions, whereas GTP hydrolysis typically functions as a switch.
Taylor B Updegrove, Jailynn Harke, Vivek Anantharaman, Jin Yang, Nikhil Gopalan, Di Wu, Grzegorz Piszczek, David M Stevenson, Daniel Amador-Noguez, Jue D Wang, L Aravind, Kumaran S Ramamurthi   +11 more
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