Results 1 to 10 of about 436,730 (400)
Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics. [PDF]
eLife, 2015 Microtubule dynamics and polarity stem from the polymerization of αβ-tubulin heterodimers. Five conserved tubulin cofactors/chaperones and the Arl2 GTPase regulate α- and β-tubulin assembly into heterodimers and maintain the soluble tubulin pool in the ...
Al-Bassam, Jawdat +7 more
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Cells, 2021 Members of the tubulin superfamily are GTPases; the activities of GTPases are necessary for life. The members of the tubulin superfamily are the constituents of the microtubules and the γ-tubulin meshwork.
Maria Alvarado Kristensson
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Growth and shortening of microtubules: a two-state model approach [PDF]
The Journal of Biological Chemistry 286(2011), 39439-39449, 2011 In this study, a two-state mechanochemical model is presented to describe the dynamic instability of microtubules (MTs) in cells. The MTs switches between two states, assembly state and disassembly state. In assembly state, the growth of MTs includes two
Akiyoshi +45 more
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Prolonging assembly through dissociation:A self assembly paradigm in microtubules [PDF]
Phys. Rev. E 83, 051904 (2011), 2011 We study a one-dimensional model of microtubule assembly/disassembly in which GTP bound to tubulins within the microtubule undergoes stochastic hydrolysis.
Bulbul Chakraborty +4 more
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Tubulin bond energies and microtubule biomechanics determined from nanoindentation in silico [PDF]
J. Am. Chem. Soc., 2014, 136(49), 17036-170045, 2015 Microtubules, the primary components of the chromosome segregation machinery, are stabilized by longitudinal and lateral non-covalent bonds between the tubulin subunits.
Ataullakhanov, Fazly I. +7 more
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Quantification of acetylated tubulin [PDF]
Cytoskeleton, 2013 The acetylation/deacetylation of Lys40 of the α-subunit is an important posttranslational modification undergone by tubulin during the life of a cell. Many previous studies have addressed the physiological role of this acetylation process using various ...
Arce, Carlos Angel +3 more
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Modeling the Effects of Drug Binding on the Dynamic Instability of Microtubules [PDF]
Phys. Biol. 8:056004 (2011), 2011 We propose a stochastic model that accounts for the growth, catastrophe and rescue processes of steady state microtubules assembled from MAP-free tubulin.
Correia J J +8 more
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On the Nature and Shape of Tubulin Trails: Implications on Microtubule Self-Organization [PDF]
Acta Biotheoretica 60, 1 (2012) 55, 2012 Microtubules, major elements of the cell skeleton are, most of the time, well organized in vivo, but they can also show self-organizing behaviors in time and/or space in purified solutions in vitro. Theoretical studies and models based on the concepts of
Glade, Nicolas
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Effects of antibodies against tubulin on the movement of reactivated sea urchin sperm flagella [PDF]
, 1980 Antibodies binding to sea urchin flagellar outer-doublet tubulin have been isolated from rabbit sera by tubulin-affinity chromatography employing electrophoretically purified tubulin as the immobilized substrate.
Asai, David J., Brokaw, Charles J.
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Frontiers in Cell and Developmental Biology, 2022 Microtubules are cytoskeletal filaments underlying the morphology and functions of all eukaryotic cells. In higher eukaryotes, the basic building blocks of these non-covalent polymers, ɑ- and β-tubulins, are encoded by expanded tubulin family genes (i.e.,
Shih-Chieh Ti
doaj +1 more source