Results 11 to 20 of about 411,364 (358)

The Tubulin Code [PDF]

Cell Cycle, 2007
Microtubules create diverse arrays with specific cellular functions such as the mitotic spindle, cilia and bundles inside neurons. How microtubules are regulated to enable specific functions is not well understood. Recent work has shown that posttranslational modifications of the tubulin building blocks mark subpopulations of microtubules and ...
Kristen J. Verhey, Jacek Gaertig
openaire   +3 more sources

Organization of the Cytoskeleton in Ectopic Foci of the Endometrium with Rare Localization

Biomedicines, 2021
(1) Background: Endometriosis is a common pathology of the female reproductive system, often accompanied by pain and decreased fertility. However, its pathogenesis has not been sufficiently studied regarding the role of the cytoskeleton.
Konstantin A. Toniyan, Victoria V. Povorova, Elena Yu. Gorbacheva, Valery V. Boyarintsev, Irina V. Ogneva   +4 more
doaj   +1 more source

Housekeeping Proteins in Meat Quality Research: Are They Reliable Markers for Internal Controls in Western Blot? A Mini Review

Meat and Muscle Biology, 2022
Advancements in technology and analytical methods enable researchers to explore the biochemical events that cause variation in meat quality. Among those, western blot techniques have been successfully used in identifying and quantifying the key proteins ...
Chaoyu Zhai, Elisabeth J. Huff-Lonergan, Mahesh N. Nair, Steven M. Lonergan   +3 more
doaj   +2 more sources

Evolutionary Divergence of Enzymatic Mechanisms for Tubulin Detyrosination

Cell Reports, 2019
Summary: The two related members of the vasohibin family, VASH1 and VASH2, encode human tubulin detyrosinases. Here we demonstrate that, in contrast to VASH1, which requires binding of small vasohibin binding protein (SVBP), VASH2 has autonomous tubulin ...
Siem van der Laan, Maude F. Lévêque, Guillaume Marcellin, Lubomir Vezenkov, Yoann Lannay, Geronimo Dubra, Guillaume Bompard, Sara Ovejero, Serge Urbach, Andrew Burgess, Muriel Amblard, Yvon Sterkers, Patrick Bastien, Krzysztof Rogowski   +13 more
doaj   +1 more source

MAPping tubulin mutations

Frontiers in Cell and Developmental Biology, 2023
Microtubules are filamentous structures that play a critical role in a diverse array of cellular functions including, mitosis, nuclear translocation, trafficking of organelles and cell shape. They are composed of α/β-tubulin heterodimers which are encoded by a large multigene family that has been implicated in an umbrella of disease states collectively
Thomas D. Cushion, Thomas D. Cushion, Ines Leca, David A. Keays, David A. Keays, David A. Keays   +5 more
openaire   +3 more sources

Transcription factor LSF facilitiates lysine methylation of α-tubulin by microtubule-associated SET8 [PDF]

, 2019
Microtubules are critical for mitosis, cell motility, and protein and organelle transport, and are a validated target for anticancer drugs. However, tubulin regulation and recruitment in these cellular processes is less understood.
Chin, Hang Gyeong, Estève, Pierre Olivier, Hansen, Ulla, Lee, Jiyoung, Pradhan, Sriharsa, Ruse, Cristian, Schaus, Scott   +6 more
core   +1 more source

γ-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis.

PLoS ONE, 2012
γ-Tubulin is the key protein for microtubule nucleation. Duplication of the γ-tubulin gene occurred several times during evolution, and in mammals γ-tubulin genes encode proteins which share ∼97% sequence identity.
Stanislav Vinopal, Markéta Cernohorská, Vadym Sulimenko, Tetyana Sulimenko, Věra Vosecká, Matyáš Flemr, Eduarda Dráberová, Pavel Dráber   +7 more
doaj   +1 more source

Abstract P-27: Computational Modeling of Tubulin Protofilament Relaxation during Rapid Freezing [PDF]

International Journal of Biomedicine, 2019
Background: Over the recent years, there has been a burst of ground-breaking studies, based on cryo-EM. They shed light on various intracellular structures, including microtubules (Alushin et al., 2014; Manka and Moores, 2018).
Dmitrii S. Vinogradov, Evgeniy V. Ulyanov, J. Richard McIntosh, Fazoil I. Ataullakhanov, Nikita B. Gudimchuk   +4 more
doaj   +1 more source

Microtubules in Bacteria: Ancient Tubulins Build a Five-Protofilament Homolog of the Eukaryotic Cytoskeleton [PDF]

, 2011
Microtubules play crucial roles in cytokinesis, transport, and motility, and are therefore superb targets for anti-cancer drugs. All tubulins evolved from a common ancestor they share with the distantly related bacterial cell division protein FtsZ, but ...
A Briegel, A Marchler-Bauer, A. J Koster, A. J Martin-Galiano, Alasdair W. McDowall, B Miroux, C Jenkins, C Suloway, C. A Sontag, C. A Sontag, C. H Aylett, C. V Iancu, D Bermudes, D Nicastro, D Schlieper, D. N Mastronarde, D. N Mastronarde, D. P Devos, E Nogales, E Nogales, E Nogales, E Nogales, E. F Pettersen, E. G Reynaud, E. I Tocheva, F Amat, Giulio Petroni, Grant J. Jensen, H Erickson, H Sui, H. P Erickson, J Cope, J Lowe, J. B Heymann, J. D Thompson, J. D Wisotzkey, J. O McInerney, J. R McIntosh, K. C Lee, K. S Makarova, K. T Tokuyasu, K. T Tokuyasu, L Gan, L Ni, L. A Amos, L. A Amos, Linda Amos, M Pilhofer, M Pilhofer, M Pilhofer, M Takeda, M Wagner, M. S Ladinsky, M. S Ladinsky, Mark S. Ladinsky, Martin Pilhofer, P Forterre, P. J Keeling, R. I Koning, S Vaughan, S. K Dutcher, S. Q Zheng, T Muller, T. K Attwood, W Ludwig, W. F Tivol, Z Li   +66 more
core   +5 more sources

Solitonic Effects of the Local Electromagnetic Field on Neuronal Microtubules [PDF]

, 2007
Current wisdom in classical neuroscience suggests that the only direct action of the electric field in neurons is upon voltage-gated ion channels which open and close their gates during the passage of ions.
Georgiev, Danko, Glazebrook, James, Papaioanou, Stelios   +2 more
core   +1 more source