Results 11 to 20 of about 420,141 (304)

Evolutionary Divergence of Enzymatic Mechanisms for Tubulin Detyrosination [PDF]

Cell Reports, 2019
Summary: The two related members of the vasohibin family, VASH1 and VASH2, encode human tubulin detyrosinases. Here we demonstrate that, in contrast to VASH1, which requires binding of small vasohibin binding protein (SVBP), VASH2 has autonomous tubulin ...
Siem van der Laan, Maude F. Lévêque, Guillaume Marcellin, Lubomir Vezenkov, Yoann Lannay, Geronimo Dubra, Guillaume Bompard, Sara Ovejero, Serge Urbach, Andrew Burgess, Muriel Amblard, Yvon Sterkers, Patrick Bastien, Krzysztof Rogowski   +13 more
doaj   +2 more sources

Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics [PDF]

eLife, 2015
Microtubule dynamics and polarity stem from the polymerization of αβ-tubulin heterodimers. Five conserved tubulin cofactors/chaperones and the Arl2 GTPase regulate α- and β-tubulin assembly into heterodimers and maintain the soluble tubulin pool in the ...
Stanley Nithianantham, Sinh Le, Elbert Seto, Weitao Jia, Julie Leary, Kevin D Corbett, Jeffrey K Moore, Jawdat Al-Bassam   +7 more
doaj   +4 more sources

Anticancer Activity of Chamaejasmine: Effect on Tubulin Protein [PDF]

Molecules, 2011
In this work, the anticancer activity of chamaejasmine was studied by evaluating its in vitro cytotoxicity against several human cancer cell lines (MCF-7, A549, SGC-7901, HCT-8, HO-4980, Hela, HepG2, PC-3, LNCap, Vero and MDCK) using the MTT assay ...
Yingkun Nie, Wenlong Fang, Songtao Liu
doaj   +2 more sources

The Game of Tubulins

Cells, 2021
Members of the tubulin superfamily are GTPases; the activities of GTPases are necessary for life. The members of the tubulin superfamily are the constituents of the microtubules and the γ-tubulin meshwork.
Maria Alvarado Kristensson
doaj   +1 more source

Reformulation of an extant ATPase active site to mimic ancestral GTPase activity reveals a nucleotide base requirement for function

eLife, 2021
Hydrolysis of nucleoside triphosphates releases similar amounts of energy. However, ATP hydrolysis is typically used for energy-intensive reactions, whereas GTP hydrolysis typically functions as a switch.
Taylor B Updegrove, Jailynn Harke, Vivek Anantharaman, Jin Yang, Nikhil Gopalan, Di Wu, Grzegorz Piszczek, David M Stevenson, Daniel Amador-Noguez, Jue D Wang, L Aravind, Kumaran S Ramamurthi   +11 more
doaj   +1 more source

Actin and Microtubules Differently Contribute to Vacuolar Targeting Specificity during the Export from the ER

Membranes, 2021
Plants rely on both actin and microtubule cytoskeletons to fine-tune sorting and spatial targeting of membranes during cell growth and stress adaptation.
Monica De Caroli, Fabrizio Barozzi, Luciana Renna, Gabriella Piro, Gian-Pietro Di Sansebastiano   +4 more
doaj   +1 more source

Organization of the Cytoskeleton in Ectopic Foci of the Endometrium with Rare Localization

Biomedicines, 2021
(1) Background: Endometriosis is a common pathology of the female reproductive system, often accompanied by pain and decreased fertility. However, its pathogenesis has not been sufficiently studied regarding the role of the cytoskeleton.
Konstantin A. Toniyan, Victoria V. Povorova, Elena Yu. Gorbacheva, Valery V. Boyarintsev, Irina V. Ogneva   +4 more
doaj   +1 more source

GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease

Cells, 2021
Glycogen synthase kinase 3 (GSK3) was initially isolated as a critical protein in energy metabolism. However, subsequent studies indicate that GSK-3 is a multi-tasking kinase that links numerous signaling pathways in a cell and plays a vital role in the ...
Daria Hajka, Bartosz Budziak, Łukasz Pietras, Przemysław Duda, James A. McCubrey, Agnieszka Gizak   +5 more
doaj   +1 more source

Role of Nuclear Lamin A/C in the Regulation of Nav1.5 Channel and Microtubules: Lesson From the Pathogenic Lamin A/C Variant Q517X

Frontiers in Cell and Developmental Biology, 2022
In this work, we studied an lmna nonsense mutation encoding for the C-terminally truncated Lamin A/C (LMNA) variant Q517X, which was described in patients affected by a severe arrhythmogenic cardiomyopathy with history of sudden death. We found that LMNA
Roberta De Zio, Giusy Pietrafesa, Serena Milano, Giuseppe Procino, Manuela Bramerio, Martino Pepe, Cinzia Forleo, Stefano Favale, Maria Svelto, Andrea Gerbino, Monica Carmosino   +10 more
doaj   +1 more source

Pharmacokinetic Profile Evaluation of Novel Combretastatin Derivative, LASSBio-1920, as a Promising Colorectal Anticancer Agent

Pharmaceutics, 2023
LASSBio-1920 was synthesized due to the poor solubility of its natural precursor, combretastatin A4 (CA4). The cytotoxic potential of the compound against human colorectal cancer cells (HCT-116) and non-small cell lung cancer cells (PC-9) was evaluated ...
Celina de Jesus Guimarães, Teiliane Rodrigues Carneiro, Marisa Jadna Silva Frederico, Guilherme G. C. de Carvalho, Matthew Little, Valder N. Freire, Victor L. B. França, Daniel Nascimento do Amaral, Jéssica de Siqueira Guedes, Eliezer J. Barreiro, Lídia Moreira Lima, Francisco W. A. Barros-Nepomuceno, Claudia Pessoa   +12 more
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