Results 21 to 30 of about 436,730 (400)

The Tubulin Code [PDF]

Cell Cycle, 2007
Microtubules create diverse arrays with specific cellular functions such as the mitotic spindle, cilia and bundles inside neurons. How microtubules are regulated to enable specific functions is not well understood. Recent work has shown that posttranslational modifications of the tubulin building blocks mark subpopulations of microtubules and ...
Kristen J. Verhey, Jacek Gaertig
openaire   +3 more sources

Cryo-EM of α-tubulin isotype-containing microtubules revealed a contracted structure of α4A/β2A microtubules

Acta Biochimica et Biophysica Sinica, 2023
Microtubules are hollow α/β-tubulin heterodimeric polymers that play critical roles in cells. In vertebrates, both α- and β-tubulins have multiple isotypes encoded by different genes, which are intrinsic factors in
Diao Lei, Zheng Wei, Zhao Qiaoyu, Liu Mingyi, Fu Zhenglin, Zhang Xu, Bao Lan, Cong Yao   +7 more
doaj   +1 more source

Revisiting the Role of ß-Tubulin in Drosophila Development: β-tubulin60D is not an Essential Gene, and its Novel Pin1 Allele has a Tissue-Specific Dominant-Negative Impact

Frontiers in Cell and Developmental Biology, 2022
Diversity in cytoskeleton organization and function may be achieved through alternative tubulin isotypes and by a variety of post-translational modifications.
Ramesh Kumar Krishnan, Naomi Halachmi, Raju Baskar, Anna Bakhrat, Raz Zarivach, Raz Zarivach, Adi Salzberg, Uri Abdu   +7 more
doaj   +1 more source

The centriolar tubulin code

Seminars in Cell & Developmental Biology, 2023
Centrioles are microtubule-based cell organelles present in most eukaryotes. They participate in the control of cell division as part of the centrosome, the major microtubule-organizing center of the cell, and are also essential for the formation of primary and motile cilia.
Guichard, Paul, Laporte, Marine H., Hamel, Virginie   +2 more
openaire   +3 more sources

Altered cytoskeletal arrangement in induced pluripotent stem cells and motor neurons from patients with riboflavin transporter deficiency

Disease Models & Mechanisms, 2021
The cytoskeletal network plays a crucial role in the differentiation, morphogenesis, function and homeostasis of the nervous tissue, so that alterations in any of its components may lead to neurodegenerative diseases.
Alessia Niceforo, Chiara Marioli, Fiorella Colasuonno, Stefania Petrini, Keith Massey, Marco Tartaglia, Enrico Bertini, Sandra Moreno, Claudia Compagnucci   +8 more
doaj   +1 more source

TUBA1A tubulinopathy mutants disrupt neuron morphogenesis and override XMAP215/Stu2 regulation of microtubule dynamics

eLife, 2022
Heterozygous, missense mutations in α- or β-tubulin genes are associated with a wide range of human brain malformations, known as tubulinopathies. We seek to understand whether a mutation’s impact at the molecular and cellular levels scale with the ...
Katelyn J Hoff, Jayne E Aiken, Mark A Gutierrez, Santos J Franco, Jeffrey K Moore   +4 more
doaj   +1 more source

MAPping tubulin mutations

Frontiers in Cell and Developmental Biology, 2023
Microtubules are filamentous structures that play a critical role in a diverse array of cellular functions including, mitosis, nuclear translocation, trafficking of organelles and cell shape. They are composed of α/β-tubulin heterodimers which are encoded by a large multigene family that has been implicated in an umbrella of disease states collectively
Thomas D. Cushion, Thomas D. Cushion, Ines Leca, David A. Keays, David A. Keays, David A. Keays   +5 more
openaire   +3 more sources

Delineating the role of βIV-Tubulins in pancreatic cancer: βIVb-tubulin inhibition sensitizes pancreatic cancer cells to vinca alkaloids [PDF]

, 2016
Pancreatic cancer (PC) is a lethal disease which is characterized by chemoresistance. Components of the cell cytoskeleton are therapeutic targets in cancer. βIV-tubulin is one such component that has two isotypes—βIVa and βIVb.
Biankin, A.V., Goldstein, D., Johns, A., Kavallaris, M., Limbri, L.F., Liu, J., McCarroll, J., Phillips, P.A., Sharbeen, G., Youkhana, J.   +9 more
core   +2 more sources

γ-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis.

PLoS ONE, 2012
γ-Tubulin is the key protein for microtubule nucleation. Duplication of the γ-tubulin gene occurred several times during evolution, and in mammals γ-tubulin genes encode proteins which share ∼97% sequence identity.
Stanislav Vinopal, Markéta Cernohorská, Vadym Sulimenko, Tetyana Sulimenko, Věra Vosecká, Matyáš Flemr, Eduarda Dráberová, Pavel Dráber   +7 more
doaj   +1 more source

Chlamydomonas reinhardtii tubulin-gene disruptants for efficient isolation of strains bearing tubulin mutations.

PLoS ONE, 2020
The single-cell green alga Chlamydomonas reinhardtii possesses two α-tubulin genes (tua1 and tua2) and two β-tubulin genes (tub1 and tub2), with the two genes in each pair encoding identical amino acid sequences.
Takako Kato-Minoura, Yutaro Ogiwara, Takashi Yamano, Hideya Fukuzawa, Ritsu Kamiya   +4 more
doaj   +1 more source