Results 21 to 30 of about 420,141 (304)

Design, Synthesis and In Vitro Biological Activity of Novel C-7 Methylene Congeners of Furanoallocolchicinoids

Pharmaceutics, 2023
A series of novel heterocyclic colchicine derivatives bearing a C-7 methylene fragment were synthesized via Wittig, Horner–Wadsworth–Emmons and Nenajdenko–Shastin olefination approaches.
Iuliia A. Gracheva, Elena V. Svirshchevskaya, Ekaterina S. Shchegravina, Yulia B. Malysheva, Alsu R. Sitdikova, Alexey Yu. Fedorov   +5 more
doaj   +1 more source

SRC Kinase-Mediated Tyrosine Phosphorylation of TUBB3 Regulates Its Stability and Mitotic Spindle Dynamics in Prostate Cancer Cells

Pharmaceutics, 2022
Tubulin is an integral part of the cytoskeleton and plays a pivotal role in cellular signaling, maintenance, and division. β-tubulin is also the molecular target for taxane compounds such as docetaxel (DTX) and cabazitaxel (CTX), both first-line ...
Alan Alfano, Jin Xu, Xi Yang, Dhanraj Deshmukh, Yun Qiu   +4 more
doaj   +1 more source

Design, Synthesis and Cytotoxic Activity Evaluation of Newly Synthesized Amides-Based TMP Moiety as Potential Anticancer Agents over HepG2 Cells

Molecules, 2022
A novel series of amides based TMP moiety was designed, synthesized and evaluated for their antiproliferative as well as enzyme inhibition activity. Compounds 6a and 6b showed remarkable cytotoxic activity against HepG2 cells with IC50 values 0.65 and 0 ...
Tarfah Al-Warhi, Adil Aldhahrani, Fayez Althobaiti, Eman Fayad, Ola A. Abu Ali, Sarah Albogami, Ali H. Abu Almaaty, Amgad I. M. Khedr, Syed Nasir Abbas Bukhari, Islam Zaki   +9 more
doaj   +1 more source

Housekeeping Proteins in Meat Quality Research: Are They Reliable Markers for Internal Controls in Western Blot? A Mini Review

Meat and Muscle Biology, 2022
Advancements in technology and analytical methods enable researchers to explore the biochemical events that cause variation in meat quality. Among those, western blot techniques have been successfully used in identifying and quantifying the key proteins ...
Chaoyu Zhai, Elisabeth J. Huff-Lonergan, Mahesh N. Nair, Steven M. Lonergan   +3 more
doaj   +2 more sources

Methoxy and bromo scans on N-(5-methoxyphenyl) methoxybenzenesulphonamides reveal potent cytotoxic compounds, especially against the human breast adenocarcinoma MCF7 cell line

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Thirty seven N-(5-methoxyphenyl)-4-methoxybenzenesulphonamide with methoxy or/and bromo substitutions (series 1-4) and with different substituents on the sulphonamide nitrogen have been synthesised.
Myriam González, María Ovejero-Sánchez, Alba Vicente-Blázquez, Manuel Medarde, Rogelio González-Sarmiento, Rafael Peláez   +5 more
doaj   +1 more source

Transcription factor LSF facilitiates lysine methylation of α-tubulin by microtubule-associated SET8 [PDF]

, 2019
Microtubules are critical for mitosis, cell motility, and protein and organelle transport, and are a validated target for anticancer drugs. However, tubulin regulation and recruitment in these cellular processes is less understood.
Chin, Hang Gyeong, Estève, Pierre Olivier, Hansen, Ulla, Lee, Jiyoung, Pradhan, Sriharsa, Ruse, Cristian, Schaus, Scott   +6 more
core   +1 more source

γ-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis.

PLoS ONE, 2012
γ-Tubulin is the key protein for microtubule nucleation. Duplication of the γ-tubulin gene occurred several times during evolution, and in mammals γ-tubulin genes encode proteins which share ∼97% sequence identity.
Stanislav Vinopal, Markéta Cernohorská, Vadym Sulimenko, Tetyana Sulimenko, Věra Vosecká, Matyáš Flemr, Eduarda Dráberová, Pavel Dráber   +7 more
doaj   +1 more source

Protection of Grouper Against Cryptocaryon irritans by Immunization With Tetrahymena thermophila and Protective Cross-Reactive Antigen Identification

Frontiers in Immunology, 2022
Vaccination is an effective method to prevent Cryptocaryon irritans infection. Although some vaccines have been developed, large-scale production of these vaccines is costly.
Zequan Mo, Zequan Mo, Zequan Mo, Huicheng Wu, Yingtong Hu, Xueli Lai, Wenjie Guo, Yafei Duan, Xueming Dan, Yanwei Li   +9 more
doaj   +1 more source

Microtubules in Bacteria: Ancient Tubulins Build a Five-Protofilament Homolog of the Eukaryotic Cytoskeleton [PDF]

, 2011
Microtubules play crucial roles in cytokinesis, transport, and motility, and are therefore superb targets for anti-cancer drugs. All tubulins evolved from a common ancestor they share with the distantly related bacterial cell division protein FtsZ, but ...
A Briegel, A Marchler-Bauer, A. J Koster, A. J Martin-Galiano, Alasdair W. McDowall, B Miroux, C Jenkins, C Suloway, C. A Sontag, C. A Sontag, C. H Aylett, C. V Iancu, D Bermudes, D Nicastro, D Schlieper, D. N Mastronarde, D. N Mastronarde, D. P Devos, E Nogales, E Nogales, E Nogales, E Nogales, E. F Pettersen, E. G Reynaud, E. I Tocheva, F Amat, Giulio Petroni, Grant J. Jensen, H Erickson, H Sui, H. P Erickson, J Cope, J Lowe, J. B Heymann, J. D Thompson, J. D Wisotzkey, J. O McInerney, J. R McIntosh, K. C Lee, K. S Makarova, K. T Tokuyasu, K. T Tokuyasu, L Gan, L Ni, L. A Amos, L. A Amos, Linda Amos, M Pilhofer, M Pilhofer, M Pilhofer, M Takeda, M Wagner, M. S Ladinsky, M. S Ladinsky, Mark S. Ladinsky, Martin Pilhofer, P Forterre, P. J Keeling, R. I Koning, S Vaughan, S. K Dutcher, S. Q Zheng, T Muller, T. K Attwood, W Ludwig, W. F Tivol, Z Li   +66 more
core   +5 more sources

Structural state recognition facilitates tip tracking of EB1 at growing microtubule ends

eLife, 2019
The microtubule binding protein EB1 specifically targets the growing ends of microtubules in cells, where EB1 facilitates the interactions of cellular proteins with microtubule plus-ends.
Taylor A Reid, Courtney Coombes, Soumya Mukherjee, Rebecca R Goldblum, Kyle White, Sneha Parmar, Mark McClellan, Marija Zanic, Naomi Courtemanche, Melissa K Gardner   +9 more
doaj   +1 more source