Results 21 to 30 of about 292,166 (345)
BMC Research Notes, 2012 Background The chemotherapeutic agent paclitaxel arrests cell division by binding to the hetero-dimeric protein tubulin. Subtle differences in tubulin sequences, across eukaryotes and among β-tubulin isotypes, can have profound impact on paclitaxel ...
Das Lalita +2 more
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Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation
Science, 2018 Severing to build microtubules Microtubules are essential intracellular polymers, built from tubulin subunits, that establish cell shape, move organelles, and segregate chromosomes during cell division. Vemu et al.
Annapurna Vemu +6 more
semanticscholar +1 more source
Frontiers in Molecular Neuroscience, 2014 Tau-tubulin kinase (TTBK) belongs to casein kinase superfamily and phosphorylates microtubule-associated protein tau and tubulin. TTBK has two isoforms, TTBK1 and TTBK2, which contain highly homologous catalytic domains but their non-catalytic domains are distinctly different.
Seiko eIkezu +2 more
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TTC5 mediates autoregulation of tubulin via mRNA degradation
Science, 2019 Mechanism of tubulin autoregulation Cells tightly control the abundance of key housekeeping factors, such as ribosomes and chaperones, to maintain them at optimal levels needed for homeostasis.
Zhewang Lin +6 more
semanticscholar +1 more source
Archaeal origin of tubulin [PDF]
Biology Direct, 2012 Tubulins are a family of GTPases that are key components of the cytoskeleton in all eukaryotes and are distantly related to the FtsZ GTPase that is involved in cell division in most bacteria and many archaea. Among prokaryotes, bona fide tubulins have been identified only in bacteria of the genus Prosthecobacter. These bacterial tubulin genes appear to
Eugene V. Koonin, Natalya Yutin
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PLoS ONE, 2020 The single-cell green alga Chlamydomonas reinhardtii possesses two α-tubulin genes (tua1 and tua2) and two β-tubulin genes (tub1 and tub2), with the two genes in each pair encoding identical amino acid sequences.
Takako Kato-Minoura +4 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Thirty seven N-(5-methoxyphenyl)-4-methoxybenzenesulphonamide with methoxy or/and bromo substitutions (series 1-4) and with different substituents on the sulphonamide nitrogen have been synthesised.
Myriam González +5 more
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Tubulin: Structure, Functions and Roles in Disease
Cells, 2019 Highly conserved α- and β-tubulin heterodimers assemble into dynamic microtubules and perform multiple important cellular functions such as structural support, pathway for transport and force generation in cell division. Tubulin exists in different forms
P. Binarová, J. Tuszynski
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Structural basis of tubulin tyrosination by tubulin tyrosine ligase [PDF]
Journal of Cell Biology, 2013 Tubulin tyrosine ligase (TTL) catalyzes the post-translational retyrosination of detyrosinated α-tubulin. Despite the indispensable role of TTL in cell and organism development, its molecular mechanism of action is poorly understood. By solving crystal structures of TTL in complex with tubulin, we here demonstrate that TTL binds to the α and β subunits
Prota Andrea E. +10 more
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Frontiers in Cell and Developmental Biology, 2022 In this work, we studied an lmna nonsense mutation encoding for the C-terminally truncated Lamin A/C (LMNA) variant Q517X, which was described in patients affected by a severe arrhythmogenic cardiomyopathy with history of sudden death. We found that LMNA
Roberta De Zio +10 more
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