Results 31 to 40 of about 408,296 (185)
Journal of Cell Biology, 2018 We used electron tomography to examine microtubules (MTs) growing from pure tubulin in vitro as well as two classes of MTs growing in cells from six species.
J. McIntosh +8 more
semanticscholar +1 more source
Solitonic Effects of the Local Electromagnetic Field on Neuronal Microtubules [PDF]
, 2007 Current wisdom in classical neuroscience suggests that the only direct action of the electric field in neurons is upon voltage-gated ion channels which open and close their gates during the passage of ions.
Georgiev, Danko +2 more
core +1 more source
Abstract P-27: Computational Modeling of Tubulin Protofilament Relaxation during Rapid Freezing [PDF]
International Journal of Biomedicine, 2019 Background: Over the recent years, there has been a burst of ground-breaking studies, based on cryo-EM. They shed light on various intracellular structures, including microtubules (Alushin et al., 2014; Manka and Moores, 2018).
Dmitrii S. Vinogradov +4 more
doaj +1 more source
Nature Cell Biology, 2018 How microtubules (MTs) are generated in the cell is a major question in understanding how the cytoskeleton is assembled. For several decades, γ-tubulin has been accepted as the universal MT nucleator of the cell. Although there is evidence that γ-tubulin
Akanksha Thawani +2 more
semanticscholar +1 more source
Pretubulysin derived probes as novel tools for monitoring the microtubule network via activity-based protein profiling and fluorescence microscopy [PDF]
, 2012 Microtubules (mt) are highly dynamic polymers composed of alpha- and beta-tubulin monomers that are present in all dividing and non-dividing cells. A broad variety of natural products exists that are known to interfere with the microtubule network, by ...
Burkhart, Jens L. +7 more
core +1 more source
Vasohibins encode tubulin detyrosinating activity
Science, 2017 Tubulin carboxypeptidase identity revealed Enzymes of the α-tubulin detyrosination/tyrosination cycle create landmarks on microtubules that are essential for their multiple cellular functions and are altered in disease.
Joppe Nieuwenhuis +10 more
semanticscholar +1 more source
Three-dimensional structure of basal body triplet revealed by electron cryo-tomography. [PDF]
, 2011 Basal bodies and centrioles play central roles in microtubule (MT)-organizing centres within many eukaryotes. They share a barrel-shaped cylindrical structure composed of nine MT triplet blades.
Agard, David A +3 more
core +2 more sources
Targeting the Achilles Heel of FtsZ: The Interdomain Cleft
Frontiers in Microbiology, 2021 Widespread antimicrobial resistance among bacterial pathogens is a serious threat to public health. Thus, identification of new targets and development of new antibacterial agents are urgently needed. Although cell division is a major driver of bacterial
Pinkilata Pradhan +3 more
doaj +1 more source
, 2018 The C. elegans tubulin family is composed of nine α-, six β-, and one γ-tubulin. Tubulins are highly conserved, functioning as α-β heterodimers that assemble into microtubules.
Hurd, Daryl D.
core +2 more sources
The role of tubulin-tubulin lattice contacts in the mechanism of microtubule dynamic instability
Nature Structural & Molecular Biology, 2018 Microtubules form from longitudinally and laterally assembling tubulin α–β dimers. The assembly induces strain in tubulin, resulting in cycles of microtubule catastrophe and regrowth.
S. Manka, C. Moores
semanticscholar +1 more source