Results 31 to 40 of about 292,166 (345)
Seminars in Cell & Developmental Biology, 2023 Centrioles are microtubule-based cell organelles present in most eukaryotes. They participate in the control of cell division as part of the centrosome, the major microtubule-organizing center of the cell, and are also essential for the formation of primary and motile cilia.
Guichard, Paul +2 more
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Abstract P-27: Computational Modeling of Tubulin Protofilament Relaxation during Rapid Freezing [PDF]
International Journal of Biomedicine, 2019 Background: Over the recent years, there has been a burst of ground-breaking studies, based on cryo-EM. They shed light on various intracellular structures, including microtubules (Alushin et al., 2014; Manka and Moores, 2018).
Dmitrii S. Vinogradov +4 more
doaj +1 more source
Journal of Cell Biology, 2018 We used electron tomography to examine microtubules (MTs) growing from pure tubulin in vitro as well as two classes of MTs growing in cells from six species.
J. McIntosh +8 more
semanticscholar +1 more source
Nature Cell Biology, 2018 How microtubules (MTs) are generated in the cell is a major question in understanding how the cytoskeleton is assembled. For several decades, γ-tubulin has been accepted as the universal MT nucleator of the cell. Although there is evidence that γ-tubulin
Akanksha Thawani +2 more
semanticscholar +1 more source
Quantification of acetylated tubulin [PDF]
Cytoskeleton, 2013 The acetylation/deacetylation of Lys40 of the α‐subunit is an important posttranslational modification undergone by tubulin during the life of a cell. Many previous studies have addressed the physiological role of this acetylation process using various approaches based on changes of acetylated tubulin (AcTubulin) content.
Chesta, María Eugenia +3 more
openaire +4 more sources
Tubulin isotype regulation maintains asymmetric requirement for α-tubulin over β-tubulin
Journal of Cell Biology, 2023 How cells regulate α- and β-tubulin to meet the demand for αβ-heterodimers and avoid consequences of monomer imbalance is not understood. We investigate the role of gene copy number and how shifting expression of α- or β-tubulin genes impacts tubulin proteostasis and microtubule function in Saccharomyces cerevisiae.
Linnea C. Wethekam, Jeffrey K. Moore
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Targeting the Achilles Heel of FtsZ: The Interdomain Cleft
Frontiers in Microbiology, 2021 Widespread antimicrobial resistance among bacterial pathogens is a serious threat to public health. Thus, identification of new targets and development of new antibacterial agents are urgently needed. Although cell division is a major driver of bacterial
Pinkilata Pradhan +3 more
doaj +1 more source
The role of tubulin-tubulin lattice contacts in the mechanism of microtubule dynamic instability
Nature Structural & Molecular Biology, 2018 Microtubules form from longitudinally and laterally assembling tubulin α–β dimers. The assembly induces strain in tubulin, resulting in cycles of microtubule catastrophe and regrowth.
S. Manka, C. Moores
semanticscholar +1 more source
The Roles of β-Tubulin Mutations and Isotype Expression in Acquired Drug Resistance
Cancer Informatics, 2007 The antitumor drug paclitaxel stabilizes microtubules and reduces their dynamicity, promoting mitotic arrest and eventually apoptosis. Upon assembly of the α/β-tubulin heterodimer, GTP becomes bound to both the α and β-tubulin monomers.
J. Torin Huzil +3 more
doaj +1 more source
Molecules, 2022 A group of novel trimethoxyphenyl (TMP)-based analogues were synthesized by varying the azalactone ring of 2-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxybenzylidene)oxazolone 1 and characterized using NMR spectral data as well as elemental microanalyses ...
Tarfah Al-Warhi +10 more
doaj +1 more source