Results 31 to 40 of about 436,730 (400)
Transcription factor LSF facilitiates lysine methylation of α-tubulin by microtubule-associated SET8 [PDF]
, 2019 Microtubules are critical for mitosis, cell motility, and protein and organelle transport, and are a validated target for anticancer drugs. However, tubulin regulation and recruitment in these cellular processes is less understood.
Chin, Hang Gyeong +6 more
core +1 more source
Effects of α-tubulin acetylation on microtubule structure and stability
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Microtubules are polymers of αβ-tubulin that play important roles in the cell. Regulation of their dynamics is critical for function and includes the posttranslational modification of tubulin.
L. Eshun-Wilson +9 more
semanticscholar +1 more source
Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules [PDF]
, 2017 Tubulin-targeting molecules are widely used cancer therapeutic agents. They inhibit microtubule-based structures, including the mitotic spindle, ultimately preventing cell division.
Coluccia, Antonio +10 more
core +1 more source
Proteolysis of tubulin and the substructure of the tubulin dimer.
Journal of Biological Chemistry, 1986 The alpha and beta subunits of tubulin each have a single highly reactive site for a variety of proteases that divides each subunit into two unequal regions. The position of cleavage is not the same for alpha and beta, since alpha is consistently cleaved into about 38- and 14-kDa pieces, while beta is cleaved into about 34- and 21-kDa pieces.
D L Sackett, J Wolff
openaire +3 more sources
BMC Research Notes, 2012 Background The chemotherapeutic agent paclitaxel arrests cell division by binding to the hetero-dimeric protein tubulin. Subtle differences in tubulin sequences, across eukaryotes and among β-tubulin isotypes, can have profound impact on paclitaxel ...
Das Lalita +2 more
doaj +1 more source
Tubulin acetylation protects long-lived microtubules against mechanical aging
Nature Cell Biology, 2017 Long-lived microtubules endow the eukaryotic cell with long-range transport abilities. While long-lived microtubules are acetylated on Lys40 of α-tubulin (αK40), acetylation takes place after stabilization and does not protect against depolymerization ...
D. Portran +4 more
semanticscholar +1 more source
Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation
Science, 2018 Severing to build microtubules Microtubules are essential intracellular polymers, built from tubulin subunits, that establish cell shape, move organelles, and segregate chromosomes during cell division. Vemu et al.
Annapurna Vemu +6 more
semanticscholar +1 more source
Functional significance may underlie the taxonomic utility of single amino acid substitutions in conserved proteins [PDF]
, 2010 We hypothesized that some amino acid substitutions in conserved proteins that are strongly fixed by critical functional roles would show lineage-specific distributions.
A Rokas +31 more
core +2 more sources
Structural basis of tubulin tyrosination by tubulin tyrosine ligase [PDF]
Journal of Cell Biology, 2013 Tubulin tyrosine ligase (TTL) catalyzes the post-translational retyrosination of detyrosinated α-tubulin. Despite the indispensable role of TTL in cell and organism development, its molecular mechanism of action is poorly understood. By solving crystal structures of TTL in complex with tubulin, we here demonstrate that TTL binds to the α and β subunits
Prota Andrea E. +10 more
openaire +4 more sources
Tubulin: Structure, Functions and Roles in Disease
Cells, 2019 Highly conserved α- and β-tubulin heterodimers assemble into dynamic microtubules and perform multiple important cellular functions such as structural support, pathway for transport and force generation in cell division. Tubulin exists in different forms
P. Binarová, J. Tuszynski
semanticscholar +1 more source