Results 41 to 50 of about 408,296 (185)
Template-free 13-protofilament microtubule–MAP assembly visualized at 8 A resolution [PDF]
, 2010 Microtubule-associated proteins (MAPs) are essential for regulating and organizing cellular microtubules (MTs). However, our mechanistic understanding of MAP function is limited by a lack of detailed structural information. Using cryo-electron microscopy
Anne Houdusse +50 more
core +2 more sources
Molecules, 2022 A group of novel trimethoxyphenyl (TMP)-based analogues were synthesized by varying the azalactone ring of 2-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxybenzylidene)oxazolone 1 and characterized using NMR spectral data as well as elemental microanalyses ...
Tarfah Al-Warhi +10 more
doaj +1 more source
Loss of tubulin deglutamylase CCP1 causes infantile‐onset neurodegeneration
EMBO Journal, 2018 A set of glutamylases and deglutamylases controls levels of tubulin polyglutamylation, a prominent post‐translational modification of neuronal microtubules.
V. Shashi +59 more
semanticscholar +1 more source
Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds [PDF]
, 2007 Tubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoeba spp.
Henriquez, Fiona L. +4 more
core +2 more sources
Quantification of acetylated tubulin [PDF]
, 2013 The acetylation/deacetylation of Lys40 of the α-subunit is an important posttranslational modification undergone by tubulin during the life of a cell. Many previous studies have addressed the physiological role of this acetylation process using various ...
Arce, Carlos Angel +3 more
core +1 more source
GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease
Cells, 2021 Glycogen synthase kinase 3 (GSK3) was initially isolated as a critical protein in energy metabolism. However, subsequent studies indicate that GSK-3 is a multi-tasking kinase that links numerous signaling pathways in a cell and plays a vital role in the ...
Daria Hajka +5 more
doaj +1 more source
Cancers, 2018 Taxanes are a class of chemotherapeutic agents that inhibit cell division by disrupting the mitotic spindle through the stabilization of microtubules. Most breast cancer (BC) tumors show resistance against taxanes partially due to alterations in tubulin ...
Babak Nami, Zhixiang Wang
semanticscholar +1 more source
Tubulin bond energies and microtubule biomechanics determined from nanoindentation in silico [PDF]
, 2015 Microtubules, the primary components of the chromosome segregation machinery, are stabilized by longitudinal and lateral non-covalent bonds between the tubulin subunits.
Ataullakhanov, Fazly I. +7 more
core +1 more source
Structural state recognition facilitates tip tracking of EB1 at growing microtubule ends
eLife, 2019 The microtubule binding protein EB1 specifically targets the growing ends of microtubules in cells, where EB1 facilitates the interactions of cellular proteins with microtubule plus-ends.
Taylor A Reid +9 more
doaj +1 more source
Organization of the Cytoskeleton in Ectopic Foci of the Endometrium with Rare Localization
Biomedicines, 2021 (1) Background: Endometriosis is a common pathology of the female reproductive system, often accompanied by pain and decreased fertility. However, its pathogenesis has not been sufficiently studied regarding the role of the cytoskeleton.
Konstantin A. Toniyan +4 more
doaj +1 more source