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The discovery of tubulin [PDF]
The Journal of Cell Biology, 2005 In 1963, improved fixation methods led to the definitive identification of microtubules (see “Microtubules get a name” JCB. 168:852). Just one year later, Gary Borisy embarked on a daring project to isolate the main component of those microtubules.
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GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease
Cells, 2021 Glycogen synthase kinase 3 (GSK3) was initially isolated as a critical protein in energy metabolism. However, subsequent studies indicate that GSK-3 is a multi-tasking kinase that links numerous signaling pathways in a cell and plays a vital role in the ...
Daria Hajka +5 more
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Structural state recognition facilitates tip tracking of EB1 at growing microtubule ends
eLife, 2019 The microtubule binding protein EB1 specifically targets the growing ends of microtubules in cells, where EB1 facilitates the interactions of cellular proteins with microtubule plus-ends.
Taylor A Reid +9 more
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Organization of the Cytoskeleton in Ectopic Foci of the Endometrium with Rare Localization
Biomedicines, 2021 (1) Background: Endometriosis is a common pathology of the female reproductive system, often accompanied by pain and decreased fertility. However, its pathogenesis has not been sufficiently studied regarding the role of the cytoskeleton.
Konstantin A. Toniyan +4 more
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Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy
Molecules, 2017 Antibody-drug conjugates (ADCs) are a class of highly potent biopharmaceutical drugs generated by conjugating cytotoxic drugs with specific monoclonal antibodies through appropriate linkers.
Hao Chen +4 more
semanticscholar +1 more source
European Journal of Biochemistry, 2000 The 20 cysteine residues of tubulin are heterogeneously distributed throughout its three‐dimensional structure. In the present work, we have used the reactivity of these cysteine residues with 5,5′‐dithiobis(2‐nitrobenzoic acid) (DTNB) as a probe to detect the global conformational changes of tubulin under different experimental conditions.
Pampi BasuSarkar +7 more
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Membranes, 2021 Plants rely on both actin and microtubule cytoskeletons to fine-tune sorting and spatial targeting of membranes during cell growth and stress adaptation.
Monica De Caroli +4 more
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Loss of tubulin deglutamylase CCP1 causes infantile‐onset neurodegeneration
EMBO Journal, 2018 A set of glutamylases and deglutamylases controls levels of tubulin polyglutamylation, a prominent post‐translational modification of neuronal microtubules.
V. Shashi +59 more
semanticscholar +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Novel Suicide Ligands of Tubulin Arrest Cancer Cells in S-Phase
Neoplasia: An International Journal for Oncology Research, 1999 It is presently accepted that the mechanism of action for all anti-tumor tubulin ligands involves the perturbation of microtubule dynamics during the G2/M phase of cell division and subsequent entry into apoptosis 1].
Ashley Davis +6 more
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