Results 51 to 60 of about 436,730 (400)
Investigation of the marine compound spongistatin 1 links the inhibition of PKCα translocation to nonmitotic effects of tubulin antagonism in angiogenesis [PDF]
, 2009 The aims of the study were to meet the demand of new tubulin antagonists with fewer side effects by characterizing the antiangiogenic properties of the experimental compound spongistatin 1, and to elucidate nonmitotic mechanisms by which tubulin ...
Bruns, Christiane J. +7 more
core +1 more source
eLife, 2020 Zinc and copper are involved in neuronal differentiation and synaptic plasticity but the molecular mechanisms behind these processes are still elusive due in part to the difficulty of imaging trace metals together with proteins at the synaptic level.
Florelle Domart +6 more
doaj +1 more source
Targeting cytoskeletal phosphorylation in cancer
Exploration of Targeted Anti-tumor Therapy, 2021 Phosphorylation of cytoskeletal proteins regulates the dynamics of polymerization, stability, and disassembly of the different types of cytoskeletal polymers. These control the ability of cells to migrate and divide.
Clara Llorente-González +2 more
doaj +1 more source
Nature Cell Biology, 2018 How microtubules (MTs) are generated in the cell is a major question in understanding how the cytoskeleton is assembled. For several decades, γ-tubulin has been accepted as the universal MT nucleator of the cell. Although there is evidence that γ-tubulin
Akanksha Thawani +2 more
semanticscholar +1 more source
Three-dimensional structure of basal body triplet revealed by electron cryo-tomography. [PDF]
, 2011 Basal bodies and centrioles play central roles in microtubule (MT)-organizing centres within many eukaryotes. They share a barrel-shaped cylindrical structure composed of nine MT triplet blades.
Agard, David A +3 more
core +2 more sources
Tubulin isotype regulation maintains asymmetric requirement for α-tubulin over β-tubulin
Journal of Cell Biology, 2023 How cells regulate α- and β-tubulin to meet the demand for αβ-heterodimers and avoid consequences of monomer imbalance is not understood. We investigate the role of gene copy number and how shifting expression of α- or β-tubulin genes impacts tubulin proteostasis and microtubule function in Saccharomyces cerevisiae.
Linnea C. Wethekam, Jeffrey K. Moore
openaire +2 more sources
, 2018 The C. elegans tubulin family is composed of nine α-, six β-, and one γ-tubulin. Tubulins are highly conserved, functioning as α-β heterodimers that assemble into microtubules.
Hurd, Daryl D.
core +2 more sources
The role of tubulin-tubulin lattice contacts in the mechanism of microtubule dynamic instability
Nature Structural & Molecular Biology, 2018 Microtubules form from longitudinally and laterally assembling tubulin α–β dimers. The assembly induces strain in tubulin, resulting in cycles of microtubule catastrophe and regrowth.
S. Manka, C. Moores
semanticscholar +1 more source
Neuron Growth Control by PDE Backstepping: Axon Length Regulation by Tubulin Flux Actuation in Soma [PDF]
arXiv, 2021 In this work, stabilization of an axonal growth in a neuron associated with the dynamics of tubulin concentration is proposed by designing a boundary control. The dynamics are given by a parabolic Partial Differential Equation (PDE) of the tubulin concentration, with a spatial domain of the axon's length governed by an Ordinary Differential Equation ...
arxiv
The Feasibility of Coherent Energy Transfer in Microtubules [PDF]
Journal of The Royal Society Interface 2014, 11: 20140677, 2014 It was once purported that biological systems were far too warm and wet to support quantum phenomena mainly due to thermal effects disrupting quantum coherence. However recent experimental results and theoretical analyses have shown that thermal energy may assist, rather than disrupt, quantum coherence, especially in the dry hydrophobic interiors of ...
arxiv +1 more source