Results 51 to 60 of about 408,296 (185)

Actin and Microtubules Differently Contribute to Vacuolar Targeting Specificity during the Export from the ER

Membranes, 2021
Plants rely on both actin and microtubule cytoskeletons to fine-tune sorting and spatial targeting of membranes during cell growth and stress adaptation.
Monica De Caroli, Fabrizio Barozzi, Luciana Renna, Gabriella Piro, Gian-Pietro Di Sansebastiano   +4 more
doaj   +1 more source

Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy

Molecules, 2017
Antibody-drug conjugates (ADCs) are a class of highly potent biopharmaceutical drugs generated by conjugating cytotoxic drugs with specific monoclonal antibodies through appropriate linkers.
Hao Chen, Zongtao Lin, K. Arnst, Duane D. Miller, Wei Li   +4 more
semanticscholar   +1 more source

Formation and Function of the Rbl2p-beta-Tubulin Complex [PDF]

, 1998
The yeast protein Rbl2p suppresses the deleterious effects of excess beta-tubulin as efficiently as does alpha-tubulin. Both in vivo and in vitro, Rbl2p forms a complex with beta-tubulin that does not contain alpha-tubulin, thus defining a second pool of
Archer, Julie E., Magendantz, Margaret, Solomon, Frank, Vega, Leticia R.   +3 more
core  

Growth and shortening of microtubules: a two-state model approach

, 2011
In this study, a two-state mechanochemical model is presented to describe the dynamic instability of microtubules (MTs) in cells. The MTs switches between two states, assembly state and disassembly state. In assembly state, the growth of MTs includes two
Akiyoshi, Armond, Asbury, Bell, Bray, Cooper, Derrida, Dogterom, Efremov, Fisher, Franck, Gao, Grill, Grishchuk, Hill, Howard, Howard, Howard, Janson, Joglekar, Joglekar, Jülicher, Kolomeisky, Kolomeisky, Kolomeisky, Koshland, McIntosh, Miranda, Molodtsov, Monod, Powers, Pury, Redner, Salmon, Schliwa, Schnitzer, Sperry, Vale, Verde, Walker, Walker, Westermann, Westermann, Yunxin Zhang, Zhang, Zhang   +45 more
core   +1 more source

Reduced tubulin tyrosination as an early marker of mercury toxicity in differentiating N2a cells [PDF]

, 2007
The aims of this work were to compare the effects of methyl mercury chloride and Thimerosal on neurite/process outgrowth and microtubule proteins in differentiating mouse N2a neuroblastoma and rat C6 glioma cells.
A.J. Hargreaves, Atchison, Barra, C. Lloyd Mills, Cambray-Deakin, Castoldi, Counter, Denizot, Dringen, Erck, Flaskos, Goldman, Graff, Hajela, Hargreaves, Heidemann, Jacobson, James, Laemmli, Lowry, M. Iqbal, M. Kontovraki, M. Lawton, Miura, Olivieri, O’Kusky, Parran, Towbin, Ueha-Ishibashi, Webster   +29 more
core   +1 more source

The Roles of β-Tubulin Mutations and Isotype Expression in Acquired Drug Resistance

Cancer Informatics, 2007
The antitumor drug paclitaxel stabilizes microtubules and reduces their dynamicity, promoting mitotic arrest and eventually apoptosis. Upon assembly of the α/β-tubulin heterodimer, GTP becomes bound to both the α and β-tubulin monomers.
J. Torin Huzil, Ke Chen, Lukasz Kurgan, Jack A. Tuszynski   +3 more
doaj   +1 more source

Novel Suicide Ligands of Tubulin Arrest Cancer Cells in S-Phase

Neoplasia: An International Journal for Oncology Research, 1999
It is presently accepted that the mechanism of action for all anti-tumor tubulin ligands involves the perturbation of microtubule dynamics during the G2/M phase of cell division and subsequent entry into apoptosis 1].
Ashley Davis, Jian-Dong Jiang, Kim M. Middleton, Yue Wang, Imre Weisz, Yi-He Ling, J. George Bekesi   +6 more
doaj   +1 more source

SRC Kinase-Mediated Tyrosine Phosphorylation of TUBB3 Regulates Its Stability and Mitotic Spindle Dynamics in Prostate Cancer Cells

Pharmaceutics, 2022
Tubulin is an integral part of the cytoskeleton and plays a pivotal role in cellular signaling, maintenance, and division. β-tubulin is also the molecular target for taxane compounds such as docetaxel (DTX) and cabazitaxel (CTX), both first-line ...
Alan Alfano, Jin Xu, Xi Yang, Dhanraj Deshmukh, Yun Qiu   +4 more
doaj   +1 more source

Balancing Act: Tubulin Glutamylation and Microtubule Dynamics in Toxoplasma gondii

Microorganisms
The success of the intracellular parasite Toxoplasma gondii in invading host cells relies on the apical complex, a specialized microtubule cytoskeleton structure associated with secretory organelles. The T. gondii genome encodes three isoforms of both α-
Inês L. S. Delgado, João Gonçalves, Rita Fernandes, Sara Zúquete, Afonso P. Basto, Alexandre Leitão, Helena Soares, Sofia Nolasco   +7 more
doaj   +1 more source

Design, Synthesis and Cytotoxic Activity Evaluation of Newly Synthesized Amides-Based TMP Moiety as Potential Anticancer Agents over HepG2 Cells

Molecules, 2022
A novel series of amides based TMP moiety was designed, synthesized and evaluated for their antiproliferative as well as enzyme inhibition activity. Compounds 6a and 6b showed remarkable cytotoxic activity against HepG2 cells with IC50 values 0.65 and 0 ...
Tarfah Al-Warhi, Adil Aldhahrani, Fayez Althobaiti, Eman Fayad, Ola A. Abu Ali, Sarah Albogami, Ali H. Abu Almaaty, Amgad I. M. Khedr, Syed Nasir Abbas Bukhari, Islam Zaki   +9 more
doaj   +1 more source