Results 61 to 70 of about 292,166 (345)

Tubulin Post-Translational Modifications and Microtubule Dynamics

International Journal of Molecular Sciences, 2017
Microtubules are hollow tube-like polymeric structures composed of α,β-tubulin heterodimers. They play an important role in numerous cellular processes, including intracellular transport, cell motility and segregation of the chromosomes during cell ...
D. Wloga, E. Joachimiak, H. Fabczak
semanticscholar   +1 more source

Theory for modeling the copolymerization of tubulin and tubulin-colchicine complex

Biophysical Journal, 1983
Substoichiometric concentrations of tubulin-colchicine complex (TC) inhibits microtubule assembly through a copolymerization reaction between tubulin and TC. We have determined the rates and extent of TC incorporation into bovine brain microtubules and developed a theory that models copolymerization.
J. Szasz, Himan Sternlicht, I. Ringel
openaire   +3 more sources

Multiscale Computational Modeling of Tubulin-Tubulin Lateral Interaction [PDF]

Biophysical Journal, 2019
Microtubules are multistranded polymers in eukaryotic cells that support key cellular functions such as chromosome segregation, motor-based cargo transport, and maintenance of cell polarity. Microtubules self-assemble via "dynamic instability," in which the dynamic plus ends switch stochastically between alternating phases of polymerization and ...
Mahya Hemmat, Brian T. Castle, Jonathan N. Sachs, David J. Odde   +3 more
openaire   +3 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Evolutionary Divergence of Enzymatic Mechanisms for Tubulin Detyrosination

Cell Reports, 2019
Summary: The two related members of the vasohibin family, VASH1 and VASH2, encode human tubulin detyrosinases. Here we demonstrate that, in contrast to VASH1, which requires binding of small vasohibin binding protein (SVBP), VASH2 has autonomous tubulin ...
Siem van der Laan, Maude F. Lévêque, Guillaume Marcellin, Lubomir Vezenkov, Yoann Lannay, Geronimo Dubra, Guillaume Bompard, Sara Ovejero, Serge Urbach, Andrew Burgess, Muriel Amblard, Yvon Sterkers, Patrick Bastien, Krzysztof Rogowski   +13 more
doaj  

Design, Synthesis and In Vitro Biological Activity of Novel C-7 Methylene Congeners of Furanoallocolchicinoids

Pharmaceutics, 2023
A series of novel heterocyclic colchicine derivatives bearing a C-7 methylene fragment were synthesized via Wittig, Horner–Wadsworth–Emmons and Nenajdenko–Shastin olefination approaches.
Iuliia A. Gracheva, Elena V. Svirshchevskaya, Ekaterina S. Shchegravina, Yulia B. Malysheva, Alsu R. Sitdikova, Alexey Yu. Fedorov   +5 more
doaj   +1 more source

A microtubule bestiary: structural diversity in tubulin polymers

Molecular Biology of the Cell, 2017
Microtubules are long, slender polymers of αβ-tubulin found in all eukaryotic cells. Tubulins associate longitudinally to form protofilaments, and adjacent protofilaments associate laterally to form the microtubule. In the textbook view, microtubules are
Sami Chaaban, G. Brouhard
semanticscholar   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Pharmacokinetic Profile Evaluation of Novel Combretastatin Derivative, LASSBio-1920, as a Promising Colorectal Anticancer Agent

Pharmaceutics, 2023
LASSBio-1920 was synthesized due to the poor solubility of its natural precursor, combretastatin A4 (CA4). The cytotoxic potential of the compound against human colorectal cancer cells (HCT-116) and non-small cell lung cancer cells (PC-9) was evaluated ...
Celina de Jesus Guimarães, Teiliane Rodrigues Carneiro, Marisa Jadna Silva Frederico, Guilherme G. C. de Carvalho, Matthew Little, Valder N. Freire, Victor L. B. França, Daniel Nascimento do Amaral, Jéssica de Siqueira Guedes, Eliezer J. Barreiro, Lídia Moreira Lima, Francisco W. A. Barros-Nepomuceno, Claudia Pessoa   +12 more
doaj   +1 more source

Posttranslational Modifications of Tubulin and Cilia.

Cold Spring Harbor Perspectives in Biology, 2017
Tubulin undergoes several highly conserved posttranslational modifications (PTMs) including acetylation, detyrosination, glutamylation, and glycylation.
D. Wloga, E. Joachimiak, Panagiota Louka, J. Gaertig   +3 more
semanticscholar   +1 more source