Results 61 to 70 of about 408,296 (185)
The FEBS Journal, 2016 Microtubules are dynamic assemblies of αβ‐tubulin heterodimers and have been recognized as highly attractive targets for cancer chemotherapy. A broad range of agents bind to tubulin and interfere with microtubule assembly.
Yuxi Wang +9 more
semanticscholar +1 more source
A bacteriophage tubulin harnesses dynamic instability to center DNA in infected cells. [PDF]
, 2014 Dynamic instability, polarity, and spatiotemporal organization are hallmarks of the microtubule cytoskeleton that allow formation of complex structures such as the eukaryotic spindle. No similar structure has been identified in prokaryotes.
Agard, David A +6 more
core +2 more sources
Pharmaceuticals, 2021 Cancer is a multifaceted disease. With the development of multi drug resistance, the need for the arousal of novel targets in order to avoid these drawbacks increased. A new series of acrylamide derivatives was synthesized from starting material 4-(furan-
Islam Zaki +6 more
doaj +1 more source
A microtubule bestiary: structural diversity in tubulin polymers
Molecular Biology of the Cell, 2017 Microtubules are long, slender polymers of αβ-tubulin found in all eukaryotic cells. Tubulins associate longitudinally to form protofilaments, and adjacent protofilaments associate laterally to form the microtubule. In the textbook view, microtubules are
Sami Chaaban, G. Brouhard
semanticscholar +1 more source
Anticancer Activity of Chamaejasmine: Effect on Tubulin Protein
Molecules, 2011 In this work, the anticancer activity of chamaejasmine was studied by evaluating its in vitro cytotoxicity against several human cancer cell lines (MCF-7, A549, SGC-7901, HCT-8, HO-4980, Hela, HepG2, PC-3, LNCap, Vero and MDCK) using the MTT assay ...
Yingkun Nie, Wenlong Fang, Songtao Liu
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Posttranslational Modifications of Tubulin and Cilia.
Cold Spring Harbor Perspectives in Biology, 2017 Tubulin undergoes several highly conserved posttranslational modifications (PTMs) including acetylation, detyrosination, glutamylation, and glycylation.
D. Wloga +3 more
semanticscholar +1 more source
Evolutionary Divergence of Enzymatic Mechanisms for Tubulin Detyrosination
Cell Reports, 2019 Summary: The two related members of the vasohibin family, VASH1 and VASH2, encode human tubulin detyrosinases. Here we demonstrate that, in contrast to VASH1, which requires binding of small vasohibin binding protein (SVBP), VASH2 has autonomous tubulin ...
Siem van der Laan +13 more
doaj
Pharmaceutics, 2023 A series of novel heterocyclic colchicine derivatives bearing a C-7 methylene fragment were synthesized via Wittig, Horner–Wadsworth–Emmons and Nenajdenko–Shastin olefination approaches.
Iuliia A. Gracheva +5 more
doaj +1 more source
Tubulin Post-Translational Modifications and Microtubule Dynamics
International Journal of Molecular Sciences, 2017 Microtubules are hollow tube-like polymeric structures composed of α,β-tubulin heterodimers. They play an important role in numerous cellular processes, including intracellular transport, cell motility and segregation of the chromosomes during cell ...
D. Wloga, E. Joachimiak, H. Fabczak
semanticscholar +1 more source
Pharmaceutics, 2023 LASSBio-1920 was synthesized due to the poor solubility of its natural precursor, combretastatin A4 (CA4). The cytotoxic potential of the compound against human colorectal cancer cells (HCT-116) and non-small cell lung cancer cells (PC-9) was evaluated ...
Celina de Jesus Guimarães +12 more
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