Results 61 to 70 of about 436,730 (400)
Template-free 13-protofilament microtubule–MAP assembly visualized at 8 A resolution [PDF]
, 2010 Microtubule-associated proteins (MAPs) are essential for regulating and organizing cellular microtubules (MTs). However, our mechanistic understanding of MAP function is limited by a lack of detailed structural information. Using cryo-electron microscopy
Anne Houdusse +50 more
core +2 more sources
Redox Report, 2021 Objectives In cancer survivors, chemotherapy-associated adverse neurological effects are described as side effects in non-targeted tissue. We investigated the role of redox-imbalance in neuronal damage by a relative low dose of Docetaxel (DTX).
Lucia Micheli +7 more
doaj +1 more source
Microtubules in Microorganisms: How Tubulin Isotypes Contribute to Diverse Cytoskeletal Functions
Frontiers in Cell and Developmental Biology, 2022 The cellular functions of the microtubule (MT) cytoskeleton range from relatively simple to amazingly complex. Assembled from tubulin, a heterodimeric protein with α- and β-tubulin subunits, microtubules are long, hollow cylindrical filaments with ...
Abesh Bera, Mohan L. Gupta
doaj +1 more source
Polymorphism in tubulin assemblies: a mechanical model [PDF]
arXiv, 2022 We investigate the mechanical origin of polymorphic structures in two-dimensional tubulin assemblies, of which microtubules are the best known example. These structures feature twisted ribbons, flat tubulin sheets, macrotubules, and hoops, and they spontaneously assemble depending on the chemical environment.
arxiv
Simulations of tubulin sheet polymers as possible structural intermediates in microtubule assembly [PDF]
PLoS ONE, 2009, 4(10): e7291., 2009 The microtubule assembly process has been extensively studied, but the underlying molecular mechanism remains poorly understood. The structure of an artificially generated sheet polymer that alternates two types of lateral contacts and that directly converts into microtubules, has been proposed to correspond to the intermediate sheet structure observed
arxiv +1 more source
Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds [PDF]
, 2007 Tubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoeba spp.
Henriquez, Fiona L. +4 more
core +2 more sources
The discovery of tubulin [PDF]
The Journal of Cell Biology, 2005 In 1963, improved fixation methods led to the definitive identification of microtubules (see “Microtubules get a name” JCB. 168:852). Just one year later, Gary Borisy embarked on a daring project to isolate the main component of those microtubules.
openaire +1 more source
Resolving controversy of unusually high refractive index of tubulin [PDF]
, 2016 Refractive index of tubulin is an important parameter underlying fundamental electromagnetic and biophysical properties of microtubules - protein fibers essential for several cell functions including cell division. Yet, the only experimental data available in the current literature show values of tubulin refractive index (n\,=\,2.36\,-\,2.90) which are
arxiv +1 more source
Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy
Molecules, 2017 Antibody-drug conjugates (ADCs) are a class of highly potent biopharmaceutical drugs generated by conjugating cytotoxic drugs with specific monoclonal antibodies through appropriate linkers.
Hao Chen +4 more
semanticscholar +1 more source
Loss of tubulin deglutamylase CCP1 causes infantile‐onset neurodegeneration
EMBO Journal, 2018 A set of glutamylases and deglutamylases controls levels of tubulin polyglutamylation, a prominent post‐translational modification of neuronal microtubules.
V. Shashi +59 more
semanticscholar +1 more source