Results 31 to 40 of about 619,494 (287)

Macrophage migration inhibitory factor downregulation: a novel mechanism of resistance to anti-angiogenic therapy. [PDF]

, 2017
Anti-angiogenic therapies for cancer such as VEGF neutralizing antibody bevacizumab have limited durability. While mechanisms of resistance remain undefined, it is likely that acquired resistance to anti-angiogenic therapy will involve alterations of the
Aghi, MK, Castro, BA, Chen, W, De Lay, M, Flanigan, P, Hoffman, D, Jahangiri, A, Kohanbash, G, Kuang, R, Mascharak, S, Okada, H, Shrivastav, S, Sidorov, M, Wagner, JR, Yagnik, G   +14 more
core   +1 more source

FABP4 deactivates NF‐κB‐IL1α pathway by ubiquitinating ATPB in tumor‐associated macrophages and promotes neuroblastoma progression

Clinical and Translational Medicine, 2021
Neuroblastoma (NB) is the most common and deadliest pediatric solid tumor. Targeting and reactivating tumor‐associated macrophages (TAMs) is necessary for reversing immune suppressive state and stimulating immune defense to exert tumoricidal function ...
Lei Miao, Zhenjian Zhuo, Jue Tang, Xiaomei Huang, Jiabin Liu, Hai‐Yun Wang, Huimin Xia, Jing He   +7 more
doaj   +1 more source

Dysregulation of macrophage polarization is associated with the metastatic process in osteosarcoma [PDF]

, 2016
Osteosarcoma (OS) is the most common bone sarcoma in adolescents, and has poor prognosis. A vicious cycle is established between OS cells and their microenvironment in order to facilitate the tumor growth and cell spreading.
Baldini, Blanchard, Celton-Jansen, Chou, Cleton-Jansen, Dalton, Edwards, Fan, Feistritzer, Fidler, Getty, Griffioen, Hass, Heymann, Heymann, Heymann, Heymann, Heymann, Heymann, Heymann, Heymann, Heymann, Hogendoorn, Holen, Hughes, Joyce, Lewis, Martinez, Meyers, Napoli, Napoli, Paget, Pollard, Pollard, Pollard, Pollard, Redini, Rodriguez, Rosen, Rédini, Saunders, Saunders, Schiffman, Schilham, Schwitter, The ESMO / European Sarcoma Network Working Group, Trichet, Wang, Wiedermann, Yang   +49 more
core   +9 more sources

Progress of research on the relationship between efferocytosis and tumor

Frontiers in Oncology
Tumors are genetic changes that develop in an organism as a result of many internal and external causes. They affect the biological behavior of cells, cause them to grow independently, and give rise to new, perpetually proliferating organisms.
Xuexin Yao, Ling Zhang, Siyi Sun, Aishuang Fu, Yanlei Ge   +4 more
doaj   +1 more source

Next frontier in tumor immunotherapy: macrophage-mediated immune evasion

Biomarker Research, 2021
Tumor-associated macrophages (TAMs), at the core of immunosuppressive cells and cytokines networks, play a crucial role in tumor immune evasion. Increasing evidences suggest that potential mechanisms of macrophage-mediated tumor immune escape imply ...
Yingqi Qiu, Tong Chen, Rong Hu, Ruiyi Zhu, Chujun Li, Yingchen Ruan, Xiaoling Xie, Yuhua Li   +7 more
doaj   +1 more source

Enhancement of radiosensitivity by the novel anticancer quinolone derivative vosaroxin in preclinical glioblastoma models [PDF]

, 2017
Purpose: Glioblastoma multiforme (GBM) is the most aggressive brain tumor. The activity of vosaroxin, a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits topoisomerase II, was investigated in GBM preclinical models as a ...
Colapietro, Alessandro, Di Cesare, Ernesto, Festuccia, Claudio, Fox, Judith A., Gravina, Giovanni Luca, Mancini, Andrea, Marampon, Francesco, Mattei, Claudia, Rossi, Giulia, Ventura, Luca, Vetuschi, Antonella, Vitale, Flora   +11 more
core   +1 more source

Ontogeny of Tumor-Associated Macrophages

Frontiers in Immunology, 2019
Tumor-associated macrophages (TAM) represent the main immune cell population of the tumor microenvironment in most cancer. For decades, TAM have been the focus of intense investigation to understand how they modulate the tumor microenvironment and their ...
Marie Laviron, Alexandre Boissonnas
doaj   +1 more source

Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies

Experimental Hematology & Oncology, 2021
Macrophages are heterogeneous cells that present as different functional phenotypes due to their plasticity. They can be classified into two categories, namely M1- and M2-like macrophages, which are involved in processes as diverse as anti-tumor activity
Shangli Zhu, Ming Yi, Yuze Wu, Bing Dong, Kongming Wu   +4 more
doaj   +1 more source

Tissue-Resident and Recruited Macrophages in Primary Tumor and Metastatic Microenvironments: Potential Targets in Cancer Therapy

Cells, 2021
Macrophages within solid tumors and metastatic sites are heterogenous populations with different developmental origins and substantially contribute to tumor progression.
Tiziana Cotechini, Aline Atallah, Arielle Grossman   +2 more
doaj   +1 more source

Targeting tumor-associated macrophages to synergize tumor immunotherapy

Signal Transduction and Targeted Therapy, 2021
The current treatment strategies in advanced malignancies remain limited. Notably, immunotherapies have raised hope for a successful control of these advanced diseases, but their therapeutic responses are suboptimal and vary considerably among ...
Xiaonan Xiang, Jianguo Wang, Di Lu, Xiao Xu   +3 more
doaj   +1 more source