Results 11 to 20 of about 9,505,976 (163)

Ontogeny of Tumor-Associated Macrophages

Frontiers in Immunology, 2019
Tumor-associated macrophages (TAM) represent the main immune cell population of the tumor microenvironment in most cancer. For decades, TAM have been the focus of intense investigation to understand how they modulate the tumor microenvironment and their ...
Marie Laviron, Alexandre Boissonnas
doaj   +2 more sources

Nanomedicines Targeting Tumor Cells or Tumor-Associated Macrophages for Combinatorial Cancer Photodynamic Therapy and Immunotherapy: Strategies and Influencing Factors [PDF]

International Journal of Nanomedicine
Yuhao Wei,1 Renwei Li,1 Yusha Wang,1,2 Jiali Fu,3 Jifeng Liu,4,5 Xuelei Ma1 1Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of China ...
Wei Y, Li R, Wang Y, Fu J, Liu J, Ma X
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Tumor Associated Macrophages in Kidney Cancer

Analytical Cellular Pathology, 2016
Tumor associated macrophages (TAMs) are an important element of tumor stroma. They originate from blood monocytes attracted by chemokines and cytokines produced by tumor cells and, being instructed by tumor microenvironment, develop into potent tumor ...
Olga V. Kovaleva, Daria V. Samoilova, Maria S. Shitova, Alexei Gratchev   +3 more
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"Re-educating" tumor-associated macrophages by targeting NF-kappaB [PDF]

, 2008
The nuclear factor kappaB (NF-kappaB) signaling pathway is important in cancer-related inflammation and malignant progression. Here, we describe a new role for NF-kappaB in cancer in maintaining the immunosuppressive phenotype of tumor-associated ...
Balkwill, F.R., Mcneish, I., Kellie A. Charles, Thorsten Hagemann, Robinson, S.C., Hagemann, T, Charles, KA, Balkwill, FR, Hagemann, T., Charles, K.A., Iain McNeish, Kulbe, H., Lawrence, T., McNeish, I, Robinson, SC, Thompson, RG, Hagen Kulbe, Richard G. Thompson, Frances R. Balkwill, Stephen C. Robinson, Toby Lawrence, Thompson, R.G., Lawrence, T, Kulbe, H   +23 more
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Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages [PDF]

, 2007
Genetic depletion of macrophages in Polyoma Middle T oncoprotein (PyMT)-induced mammary tumors in mice delayed the angiogenic switch and the progression to malignancy.
Pollard, Jeffrey W, Bricard, Gabriel, Wang, Weigang, Deng, Yan, Porcelli, Steven A, Sellers, Rani, Lin, Elaine Y, Li, Jiu-feng   +7 more
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Macrophages as a source of tumoricidal activity (tumor-necrotizing factor) [PDF]

, 1980
Macrophage-enriched peritoneal exudate cells from mice infected with Mycobacterium bovis BCG, macrophage-like tumor cells (PU 5-1.8), and peritoneal macrophages propagated in vitro with macrophage growth factor released tumoricidal activity into the ...
Mannel, D N, Moore, R. N., Männel, D. N., Mergenhagen, S E, Mergenhagen, S. E., Moore, R N   +5 more
core   +1 more source

Tumor-induced myeloid cell plasticity toward lymphatic endothelium [PDF]

, 2009
Tumor-associated lymphangiogenesis contributes to tumor progression by regulating interstitial fluid pressure, transporting immune cells to the tumor site and providing a route for metastatic dissemination.
Baeriswyl, Vanessa
core   +1 more source

The Role of Metabolic Plasticity of Tumor-Associated Macrophages in Shaping the Tumor Microenvironment Immunity

, 2022
SIMPLE SUMMARY: Tumor associated macrophages (TAMs) support disease progression by providing tumor cells cytokines and chemokines necessary for malignant growth and nutrient support. In the tumor microenvironment (TME), TAMs often rewire their metabolism
Md Nabiul Hasan, Capuk, Okan, Shivani M. Patel, Dandan Sun, Hasan, Md Nabiul, Patel, Shivani M., Sun, Dandan, Okan Capuk   +7 more
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Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state [PDF]

, 2001
Background: Macrophages sense microorganisms through activation of members of the Toll-like receptor family, which initiate signals linked to transcription of many inflammation associated genes.
Aderem, A, Underhill David M, Ozinsky, A O, Underhill, D. M., Ozinsky, A.O., Sweet Matthew J, Hume, D A, Liew Foo Y, Sweet, M J, Underhill, D M, Liew, F Y, Liew, F.Y., Aderem, A., Sweet, M. J., Hume, D. A., Hume David A, Ozinsky Adrian O, Aderem Alan   +17 more
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Influencing Factors and Significance of Tumor-associated Macrophage Polarization 
in Tumor Microenvironment

Chinese Journal of Lung Cancer, 2023
Tumor-associated macrophages (TAMs), characterized by high plasticity, are the most abundant immune cells in the tumor microenvironment (TME). TAMs are recruited to tumor region in response to various TME components such as cytokines, chemokines as well ...
Wenke GE, Weibing WU
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