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Synthesis of Fluorinated Analogues of Tumor-Associated Carbohydrate and Glycopeptide Antigens
Synlett, 2009Partial structures of tumor-associated mucin glycoproteins are interesting target structures for the development of selective anticancer vaccines. To probe the effect of fluorination on the immunological and metabolic properties of mucin glycopeptides, six novel fluorinated glycosyl-threonine conjugates have been synthesized.
Anja Hoffmann-Röder +2 more
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Aberrant Glycosylation In Tumors And Tumor-Associated Carbohydrate Antigens
1989Publisher Summary Aberrant glycosylation is the most common phenomenon associated with oncogenic transformation expressed in cell membranes of animal and human cancer cells. Such aberrant structures at the surface membranes may well be effective targets in prevention, diagnosis, and treatment of human cancer.
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The Journal of Immunology, 1996
Abstract We report in this work a human-derived self-assembling polypeptide based on the tetramerization domain of the human transcription factor p53, which can be fused to single-chain Fv Ab (scFv) fragments via a long and flexible hinge sequence of human origin, allowing exploitation of the functional affinity increase of binding to
Rheinnecker, M. +9 more
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Abstract We report in this work a human-derived self-assembling polypeptide based on the tetramerization domain of the human transcription factor p53, which can be fused to single-chain Fv Ab (scFv) fragments via a long and flexible hinge sequence of human origin, allowing exploitation of the functional affinity increase of binding to
Rheinnecker, M. +9 more
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Synthesis of non-natural glycosylamino acids containing tumor-associated carbohydrate antigens
Tetrahedron, 2003Abstract The synthesis of biologically relevant glycosylamino acids using a non-natural amino acid as the glycosyl acceptor is described. The glycosylation reaction of a monosaccharide tri-chloroacetimidate donor with Fmoc- l -hydroxynorleucine benzyl ester provided the α-O-linked product.
Stacy J. Keding +2 more
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Tumor-associated carbohydrate antigens: Biomarker discovery and clinical application
Tumor-Associated Carbohydrate Antigens (TACAs) are carbohydrate structures uniquely expressed on the surface of tumor cells while being absent or minimally present in normal tissues. These molecular signatures play crucial roles in tumor progression, contributing to essential processes such as cell adhesion, motility, invasion, immune evasion ...Teresa, Freire, Valeria, da Costa
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[Tumor-associated carbohydrate antigens related to blood group carbohydrates].
Gan to kagaku ryoho. Cancer & chemotherapy, 1986Biochemical studies have revealed the alteration of carbohydrate structures of cell membrane glycolipids, glycoproteins and cell secretory products associated with neoplastic transformation. Immunohistochemical examination of the blood group carbohydrate antigens in various cancer tissues have revealed the following results.
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Possible roles of tumor-associated carbohydrate antigens.
Cancer research, 1996Recent progress in the studies on the roles of carbohydrates has brought about critical discoveries, which allow us to have working hypotheses for understanding the roles of tumor-associated carbohydrate antigens. In this report, I focus my description on three different aspects of this progress.
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Chapter 4 Tumor-associated carbohydrate antigens and modified blood group antigens
1996Publisher Summary This chapter discusses the present knowledge of tumor-associated carbohydrate antigens (TACA's). It also discusses the pathobiological and functional significance of TACA's. A large number of monoclonal antibody (mAbs) showed distinctive reactivity with tumor cells but not with normal cells were found to be directed to carbohydrate ...
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Tumor-Associated Carbohydrate Antigens (TACA) as Novel Targets for Anticancer Therapy
Matthias Ocker +2 moreexaly +4 more sources
Antibodies against Tumor associated Carbohydrate Antigen
Anticorps contre l'antigènes glucidique associé à la tumeur Cette recherche vise à élucider les mécanismes structurels et les caractéristiques de liaison aux glycanes de l'IgM de Mannitou et de son fragment Fab, en se concentrant sur leurs interactions avec les antigènes glucidiques associés aux tumeurs (TACA), tels que le paucimannose.openaire +1 more source