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Tumor-Associated Carbohydrate Antigens Targeting Immunotherapy
Trends in Glycoscience and Glycotechnology, 2021 exaly +2 more sources
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Possible functions of tumor-associated carbohydrate antigens
Current Opinion in Immunology, 1991Expression of some tumor-associated carbohydrate antigens may define the stage, rate and phenotype of tumor progression and may have prognostic value. Some of these antigens are now recognized as adhesion molecules that define the site of metastasis. Monoclonal antibodies to tumor-associated carbohydrate antigens, or the antigens themselves, may serve ...
S Hakomori
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Tumor-Associated Carbohydrate Antigens
Annual Review of Immunology, 1984S Hakomori
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Tumor‐associated carbohydrate antigens: A possible avenue for cancer prevention
Immunology & Cell Biology, 2005Here we examine the use of glycopeptides containing tumour‐associated carbohydrate antigens (TACA) as potential preventive vaccines for carcinomas. Our recent results suggest that CD8+ T cells (CTL) are capable of recognizing TACA in a conventional class I MHC‐restricted fashion.
Yanfei, Xu +4 more
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Elevation of Tumor-associated Carbohydrate Antigens in Patients with Diffuse Panbronchiolitis
American Review of Respiratory Disease, 1993Abstract We investigated the serum levels of the tumor-associated carbohydrate antigens sialyl SSEA-1 (SLX) and sialyl Lewisa (CA19-9) in patients with diffuse panbronchiolitis (DPB) and other nonmalignant lung diseases. Both antigens were high in the serum and bronchoalveolar lavage fluid (BALF) of patients with DPB, bronchiectasis ...
H, Mukae +7 more
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Tumor-associated carbohydrate antigens in primary pulmonary adenocarcinomas and their metastases
Human Pathology, 1992To better understand the metastatic behavior of pulmonary adenocarcinoma, we studied the differences in carbohydrate antigens between primary tumors and their metastases using three monoclonal antibodies (FH-2 defining Lewis [Le]x, AH-6 defining Le(y), and FH-6 defining sialyl Le(x-i)) on 56 autopsy cases (including 15 cases in which primary tumors ...
K, Sugiyama +3 more
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Biosignals Modulated by Tumor‐Associated Carbohydrate Antigens
Annals of the New York Academy of Sciences, 2006Abstract: Based on the remodeling of glycosphingolipids on the human tumor cell lines with manipulation of glycosyltransferase genes, roles of sugar moieties in tumor‐associated carbohydrate antigens have been analyzed. Two main topics, that is, the roles of ganglioside GD3 in human malignant melanomas and those of GD2 in small cell lung cancer (SCLC)
Koichi, Furukawa +3 more
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Advances in Carbohydrate Chemistry and Biochemistry, 2017
Carcinomas express unique carbohydrates, known as tumor-associated carbohydrate antigens (TACAs), on their surface. These are potential targets for anticancer vaccines; however, to date, no such vaccine has reached the clinic. One factor that may complicate the success of this effort is the lability of the glycosidic bond. Acetal-free carbohydrates are
John F Trant, Michael R Reynolds
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Carcinomas express unique carbohydrates, known as tumor-associated carbohydrate antigens (TACAs), on their surface. These are potential targets for anticancer vaccines; however, to date, no such vaccine has reached the clinic. One factor that may complicate the success of this effort is the lability of the glycosidic bond. Acetal-free carbohydrates are
John F Trant, Michael R Reynolds
exaly +3 more sources
Enzymatic Synthesis of Tumor-Associated Carbohydrate Antigen Globo-H Hexasaccharide
Organic Letters, 2008We report the enzymatic synthesis of an important tumor-associated carbohydrate antigen, Globo-H hexasaccharide. Starting with Lac-OBn as the initial acceptor, this approach employs three glycosyltransferases: LgtC, an alpha1,4-galactosyltransferase; LgtD, a bifunctional beta1,3-galactosyl/beta1,3-N-acetylgalactosaminyltransferase; and WbsJ, an alpha1 ...
Doris M, Su +5 more
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Recent Advance in Tumor-associated Carbohydrate Antigens (TACAs)-based Antitumor Vaccines
ACS Chemical Biology, 2016Cancer cells can be distinguished from normal cells by displaying aberrant levels and types of carbohydrate structures on their surfaces. These carbohydrate structures are known as tumor-associated carbohydrate antigens (TACAs). TACAs were considered as promising targets for the design of anticancer vaccines. Unfortunately, carbohydrates alone can only
Fengshan Wang, Abdul Sami Shaikh
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