Results 251 to 260 of about 24,022 (284)
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Elevation of Tumor-associated Carbohydrate Antigens in Patients with Diffuse Panbronchiolitis
American Review of Respiratory Disease, 1993Abstract We investigated the serum levels of the tumor-associated carbohydrate antigens sialyl SSEA-1 (SLX) and sialyl Lewisa (CA19-9) in patients with diffuse panbronchiolitis (DPB) and other nonmalignant lung diseases. Both antigens were high in the serum and bronchoalveolar lavage fluid (BALF) of patients with DPB, bronchiectasis ...
H, Mukae +7 more
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Tumor-associated carbohydrate antigens in primary pulmonary adenocarcinomas and their metastases
Human Pathology, 1992To better understand the metastatic behavior of pulmonary adenocarcinoma, we studied the differences in carbohydrate antigens between primary tumors and their metastases using three monoclonal antibodies (FH-2 defining Lewis [Le]x, AH-6 defining Le(y), and FH-6 defining sialyl Le(x-i)) on 56 autopsy cases (including 15 cases in which primary tumors ...
K, Sugiyama +3 more
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Biosignals Modulated by Tumor‐Associated Carbohydrate Antigens
Annals of the New York Academy of Sciences, 2006Abstract: Based on the remodeling of glycosphingolipids on the human tumor cell lines with manipulation of glycosyltransferase genes, roles of sugar moieties in tumor‐associated carbohydrate antigens have been analyzed. Two main topics, that is, the roles of ganglioside GD3 in human malignant melanomas and those of GD2 in small cell lung cancer (SCLC)
Koichi, Furukawa +3 more
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Enzymatic Synthesis of Tumor-Associated Carbohydrate Antigen Globo-H Hexasaccharide
Organic Letters, 2008We report the enzymatic synthesis of an important tumor-associated carbohydrate antigen, Globo-H hexasaccharide. Starting with Lac-OBn as the initial acceptor, this approach employs three glycosyltransferases: LgtC, an alpha1,4-galactosyltransferase; LgtD, a bifunctional beta1,3-galactosyl/beta1,3-N-acetylgalactosaminyltransferase; and WbsJ, an alpha1 ...
Doris M, Su +5 more
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Synthesis of Fluorinated Analogues of Tumor-Associated Carbohydrate and Glycopeptide Antigens
Synlett, 2009Partial structures of tumor-associated mucin glycoproteins are interesting target structures for the development of selective anticancer vaccines. To probe the effect of fluorination on the immunological and metabolic properties of mucin glycopeptides, six novel fluorinated glycosyl-threonine conjugates have been synthesized.
Anja Hoffmann-Röder +2 more
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Aberrant Glycosylation In Tumors And Tumor-Associated Carbohydrate Antigens
1989Publisher Summary Aberrant glycosylation is the most common phenomenon associated with oncogenic transformation expressed in cell membranes of animal and human cancer cells. Such aberrant structures at the surface membranes may well be effective targets in prevention, diagnosis, and treatment of human cancer.
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Tumor-Associated Carbohydrate Antigens (TACA) as Novel Targets for Anticancer Therapy
Francesco Muraca +2 moreexaly +4 more sources
Synthesis of non-natural glycosylamino acids containing tumor-associated carbohydrate antigens
Tetrahedron, 2003Abstract The synthesis of biologically relevant glycosylamino acids using a non-natural amino acid as the glycosyl acceptor is described. The glycosylation reaction of a monosaccharide tri-chloroacetimidate donor with Fmoc- l -hydroxynorleucine benzyl ester provided the α-O-linked product.
Stacy J. Keding +2 more
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The Journal of Immunology, 1996
Abstract We report in this work a human-derived self-assembling polypeptide based on the tetramerization domain of the human transcription factor p53, which can be fused to single-chain Fv Ab (scFv) fragments via a long and flexible hinge sequence of human origin, allowing exploitation of the functional affinity increase of binding to
Rheinnecker, M. +9 more
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Abstract We report in this work a human-derived self-assembling polypeptide based on the tetramerization domain of the human transcription factor p53, which can be fused to single-chain Fv Ab (scFv) fragments via a long and flexible hinge sequence of human origin, allowing exploitation of the functional affinity increase of binding to
Rheinnecker, M. +9 more
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Tumor-associated carbohydrate antigens: Biomarker discovery and clinical application
Tumor-Associated Carbohydrate Antigens (TACAs) are carbohydrate structures uniquely expressed on the surface of tumor cells while being absent or minimally present in normal tissues. These molecular signatures play crucial roles in tumor progression, contributing to essential processes such as cell adhesion, motility, invasion, immune evasion ...Teresa, Freire, Valeria, da Costa
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