Results 241 to 250 of about 612,424 (282)

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

The spatial immune landscape predicts outcome and reveals the central role of tumor-associated macrophages in inflammatory breast cancer biology. [PDF]

Breast Cancer Res
Van Berckelaer C, Van Laere S, Vermeulen C, Kockx M, Waumans Y, Marien K, Rypens C, Missal N, Berditchevski F, Bertucci F, Vermeulen P, Dirix L, Colpaert C, Devi GR, Van Dam P.   +14 more
europepmc   +1 more source

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

Targeting IRG1 in tumor-associated macrophages for cancer therapy. [PDF]

Protein Cell
Liu S, Wei LX, Yu Q, Guo ZW, Zhan CY, Chen LL, Li Y, Ye D.   +7 more
europepmc   +1 more source

Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression

Advanced Science, EarlyView.
Mechanisms of Bufalin‐Mediated Intervention in Breast Cancer. ABSTRACT Breast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects. This study shows that bufalin inhibits malignant proliferation of MDA‐MB‐231 and MCF‐7 cells
Siyu Guo, Xiaodong Chen, Haojia Wang, Jiying Zhou, Peiying Lu, Jiangying Liu, Keyan Chai, Jingyuan Zhang, Siyun Yang, Shan Lu, Yifei Gao, Zhengsen Jin, Xiaoyu Tao, Zhongdong Hu, Qinglin Li, Jiarui Wu   +15 more
wiley   +1 more source

Bioinformatics Analysis of Tumor-Associated Macrophages in Hepatocellular Carcinoma and Establishment of a Survival Model Based on Transformer. [PDF]

Int J Mol Sci
Zeng Z, Rao S, Zhang J.
europepmc   +1 more source

Tumor-associated macrophages: potential role in skeletal involvement in classic Hodgkin lymphoma. [PDF]

J Pathol Clin Res
Andersen MD, Wolter K, Enemark MH, Pedersen MA, Gormsen LC, Lauridsen KL, Starklint J, Hamilton-Dutoit SJ, d'Amore F, Ludvigsen M, Kamper P.   +10 more
europepmc   +1 more source

Tumor-infiltrating lymphocytes and tumor-associated macrophages in cancer immunoediting: a targetable therapeutic axis. [PDF]

Front Immunol
Mukherjee S, Ghosh A, Chakraborty S, Basak U, Mukherjee S, Das T, Sa G.   +6 more
europepmc   +1 more source

TAF15 in tumor-associated macrophages enhances protumorigenic polarization and promotes cholangiocarcinoma progression. [PDF]

JHEP Rep
Liu Y, Xu B, Zhao T, Liu H, Pan Y, Zhao S, Chen Q, Wang L, Bai G, Zhang N, Zhou Y, Wei J, Fu X, Zhou Y, Wang Z, Xu L, Zhu Y, Shen S, Yang S, Zhou L, Wang L.   +20 more
europepmc   +1 more source

Inhibiting SLAMF8 modulates tumor-associated macrophages and restores CD8+ T cell-mediated antitumor immunity in colorectal cancer. [PDF]

Oncoimmunology
Han X, Bai X, Wang N, Sun Y, Hu J, Li L, Liu Z, Zhang Y, Liang Z, Sang L, Han L, Zhang Q, Qian X.   +12 more
europepmc   +1 more source