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Phenotyping Tumor-Associated Macrophages
2018Multi-parametric flow cytometry of tumor-bearing murine nonlymphoid tissue allows for characterization, isolation, and examination of immune cell composition, phenotype, and function. Here we describe an approach to process nonlymphoid tissues and then utilize a base antibody panel to define all of the major immune cell types in a single staining ...
R, Ian Cumming, Yen-Rei A, Yu
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Lipid Metabolism in Tumor-Associated Macrophages
2021Macrophages are essential components of the immune system in tumors. It can be recruited and educated to two mainly polarized subpopulations (M1-like and M2-like) of tumor-associated macrophages (TAMs) to display anti-tumor or protumor function during the tumor occurrence and progression.
Yuancai, Xiang, Hongming, Miao
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Therapeutic targeting of tumor-associated macrophages
2021Tumor-associated macrophages are among the most abundant non-cancerous cells in the tumor microenvironment and in many cancers macrophage infiltration into the tumor is associated with poor prognosis. Macrophages contribute to tumor development by promoting angiogenesis and immune suppression, and display remarkable phenotypic heterogeneity in the ...
Rasmussen, Rikke Kongsgaard; id_orcid 0000-0002-3366-7931 +1 more
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Immunoregulating activity of tumor-associated macrophages
Cancer Immunology Immunotherapy, 1986In this report, we examine the antigen nonspecific immunoregulating activity of macrophages isolated from the murine methylcholanthrene-induced fibrosarcoma FSA. These cells were shown to enhance the primary anti-CRBC PFC response of whole normal spleen cells in a dose-dependent fashion.
G J, Dougherty, W H, McBride
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Tumor-associated macrophages: a molecular perspective
International Immunopharmacology, 2002The "macrophage balance hypothesis" was proposed in the early 1990s to depict the complex relationship that tumor-associated macrophages (TAM) have with the neoplastic cells of the tumor. TAM represent a prominent component of the mononuclear leukocyte population of solid tumors, which displays an ambivalent relationship with tumors.
SICA, Antonio, Saccani A, Mantovani A.
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Tumor-associated macrophages in thoracic malignancies
Lung Cancer, 2013Tumor-associated macrophages (TAMs) can be abundantly present in numerous cancer types. Under influence of various stimuli in the tumor microenvironment TAMs develop into a tumor-inhibitory (M1) or tumor-promoting (M2) phenotype. Recently, the role of TAMs in tumor biology and their prognostic value in cancer has become a major topic of interest.
Lievense, Sanne +3 more
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Tumor-associated macrophages: a short compendium
Cellular and Molecular Life Sciences, 2019Macrophages play an important role in tissue development and homeostasis. They serve as a nexus between adaptive and innate immunity, and employ considerable plasticity. In cancer, they play a pivotal role in chronic inflammation and tumor growth either by directly stimulating the proliferation of cancer cells or by producing angiogenic and ...
Hans Prenen, Massimiliano Mazzone
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Tumor associated macrophages in gynecologic cancers
Gynecologic Oncology, 2018The complex tumor microenvironment in gynecologic cancers plays a major role in modulating anti-tumor immune responses. The interaction of cancer cells with the diverse spectrum of immune effector cells has an important impact on the efficacy of standard chemotherapy and novel immunotherapy approaches.
Venkatesh Krishnan +3 more
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Tumor-Associated Macrophages in Breast Cancer
Journal of Mammary Gland Biology and Neoplasia, 2002Neoplastic cells form only one part of a complex network of cell types that make up a breast tumor. The normal cell types that make up the nonneoplastic components of tumors include fibroblasts, endothelium, and inflammatory cells, such as tumor associated macrophages (TAMs).
Russell D, Leek, Adrian L, Harris
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Targeting Tumor-Associated Macrophages in Cancer
Trends in Immunology, 2019Macrophages are phagocytes that serve as a first line of defense against pathogenic insults to tissues. These innate immune cells mount proinflammatory responses to pathogens and repair damaged tissues. However, tumor-associated macrophages (TAMs) express cytokines and chemokines that can suppress antitumor immunity and promote tumor progression ...
Paulina, Pathria +2 more
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