Results 231 to 240 of about 9,505,641 (261)

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source

Targeting tumor-associated macrophages through phytochemicals: a promising strategy for cold tumor therapy. [PDF]

Chin Med
Shue T, Guo Y, Zhou P, Yao D, Liao H, Long C, Qi Y, Yang L, Chen N.   +8 more
europepmc   +1 more source

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

Advanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu   +12 more
wiley   +1 more source

Tumor-associated macrophages and lineage plasticity in prostate cancer: from established myeloid programs to emerging spatial hypotheses. [PDF]

Front Immunol
Li J, Li J, Zhao Y, Yu Y, Cui X.
europepmc   +1 more source

Tumor-associated macrophages in cancer: from mechanisms to application. [PDF]

Mol Biomed
Tang W, Wang X, Han B, Jiang SH, Cao H.
europepmc   +1 more source

Research trends of tumor-associated macrophages in colorectal cancer: a bibliometric analysis. [PDF]

Int J Surg
Long Y, Wang X, Chao X, Yang Y, Jin S, Zhang H.   +5 more
europepmc   +1 more source

STXBP6-driven signaling cascade alters lipid peroxidation in tumor-associated macrophages to facilitate ovarian cancer progression. [PDF]

Redox Biol
Wang M, Wang J, Xu H, Zhang S, Jin F, Li Q, Yang Z.   +6 more
europepmc   +1 more source

Camptothecin Nanowires Induce the cGAS-STING Pathway to Remold Tumor-Associated Macrophages for Antitumor Immunity. [PDF]

Pharmaceutics
Zhang C, Wu H, Chen X, Yin W, Huang S, Wen D, Song X, Xu X, Zhang C, Tai S.   +9 more
europepmc   +1 more source

The role of tumor-associated macrophages in cancer development and their significance as prognostic markers. [PDF]

Clin Exp Med
Salmaninejad A, Layeghi SM, Falakian Z, Foroushani PS, Golestani S, Pourghazi F, Kobravi S, Yousefi M.   +7 more
europepmc   +1 more source