Results 81 to 90 of about 9,505,641 (261)
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Tissue‐Resident Macrophages in Cancer: Friend or Foe?
Cancer MedicineIntroduction Macrophages are essential in maintaining homeostasis, combating infections, and influencing the process of various diseases, including cancer.
Jianhua Chi, Qinglei Gao, Dan Liu
doaj +1 more source
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
Selective targeting of tumor associated macrophages in different tumor models [PDF]
, 2018 Tumor progression largely depends on the presence of alternatively polarized (M2) tumor-associated macrophages (TAMs), whereas the classical M1-polarized macrophages can promote anti-tumorigenic immune responses.
Bernhard Brüne +27 more
core +1 more source
The Role of Macrophages in Cancer: From Basic Research to Clinical Applications
MedCommMacrophages are innate immune cells that extensively infiltrate and play a key role in the tumor microenvironment (TME). Tumor cell–secreted factors recruit monocytes into the TME, where they differentiate into tumor‐associated macrophages (TAMs), which ...
Zhimei Liu +5 more
doaj +1 more source
The role of macrophages in oral cancer: A narrative review
Saudi Journal of Oral SciencesOne of the immune cells that are most prevalent in the tumor microenvironment of tumors is the macrophage, and in most malignancies, the macrophage’s presence is correlated with a worse survival rate.
Rezhat Abbas +2 more
doaj +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Tumor-associated macrophages and cancer metastasis [PDF]
Records of Pharmaceutical & Biomedical SciencesTumour-associated macrophages (TAMs) play an important role in cancer metastasis by creating a favourable microenvironment for cancer cell survival, growth, and spread.
Morkoss Fakhry +3 more
doaj +1 more source
The role of tumor-associated macrophages and PD-1/PD-L1 networking in colorectal cancer
Colorectal cancer (CRC) is the fourth most common cancer worldwide and a leading cause of cancer-related mortality. Despite improvements in cancer prevention, early diagnosis, and therapeutic options, metastatic CRC (mCRC) remains a major challenge, with
Evangeli Lampri +9 more
core +1 more source