Results 201 to 210 of about 141,925 (244)

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Spatiotemporally Controlled Sequential Chemo‐Immunotherapy Activates Pyroptosis for Robust Anti‐Tumor Immunotherapy

Advanced Science, EarlyView.
A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun, Ruiqi Wu, Qingshuang Tang, Yunli Xu, Wanrui Shi, Mengxin Wang, Haonan Wang, Yan Luo, Cheng Ma, Xiaolong Liang   +9 more
wiley   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

Matrix Rigidity Mechanoprimes Microglia for Inflammation Through Cytoskeletal‐to‐Nuclear Signaling and 3D Spatio‐Epigenomic Remodeling

Advanced Science, EarlyView.
Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng, Jaegeon Joo, Yu Meng Li, Cheng Ji Li, Ali Taghizadeh, Seung Jae Shin, Buuvee Bayarkhangai, Tae‐Woo Ha, Sak Lee, Jaewoo Chung, Bo‐Eun Yoon, Hye Sung Kim, Inkyung Jung, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +15 more
wiley   +1 more source

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Advances in 3D Vascularized Tumor-on-a-Chip Technology

2022
Tumors disrupt the normal homeostasis of human body as they proliferate in abnormal speed. For constant proliferation, tumors recruit new blood vessels transporting nutrients and oxygen. Immune system simultaneously recruits lymphatic vessels to induce the death of tumor cells. Hence, understanding tumor dynamics are important to developing anti-cancer
Sangmin, Jung, Hyeonsu, Jo, Sujin, Hyung, Noo Li, Jeon   +3 more
openaire   +2 more sources

The design basis and application in urology of the tumor-on-a-chip platform

Urologic Oncology: Seminars and Original Investigations, 2022
Clinical research has been desperately looking for effective treatments for tumors. As the molecular mechanisms of tumors have not been thoroughly defined, and the problem of anti-tumor drug resistance and clinical drug screening are not effective, new ways are currently needed to explore and improve.
Fei Sheng, Rui-peng Jia
openaire   +2 more sources

Ex Vivo Evaluation of Combination Immunotherapy Using Tumor‐Microenvironment‐on‐Chip

Advanced Healthcare Materials, 2023
AbstractCombination immunotherapy has emerged as a promising strategy to address the challenges associated with immune checkpoint inhibitor (ICI) therapy in breast cancer. The efficacy of combination immunotherapy hinges upon the intricate and dynamic nature of the tumor microenvironment (TME), characterized by cellular heterogeneity and molecular ...
Hsuan‐Yu Mu, Chiao‐Min Lin, Li‐An Chu, Ya‐Hui Lin, Ji Li, Chao‐Yu Liu, Hsi‐Chien Huang, Sheng‐Liang Cheng, Tsung‐Ying Lee, Hsin Mei Lee, Hsin‐Min Chen, Yun‐Jen Tsai, Yunching Chen, Jen‐Huang Huang   +13 more
openaire   +2 more sources

Tumor-on-a-chip platforms for assessing nanoparticle-based cancer therapy

Nanotechnology, 2018
Abstract Cancer has become the most prevalent cause of deaths, placing a huge economic and healthcare burden worldwide. Nanoparticles (NPs), as a key component of nanomedicine, provide alternative options for promoting the efficacy of cancer therapy.
Yimin Wang, Fabio Cuzzucoli, Andres Escobar, Siming Lu, Liguo Liang, ShuQi Wang   +5 more
openaire   +2 more sources

Developing Tumor-on-a-Chip Systems with 3D Printing Technology

Tissue Engineering Part B: Reviews
Cancer remains a significant global health challenge, necessitating advanced in vitro models for understanding relevant mechanisms and developing effective treatment approaches. Considered as a new paradigm of in vitro models, tumor-on-a-chip technology
Yandong Xie, Yanwen Su, Yuyang Gu, Kaili Liu, Xiaoyu Guo, Chaoyin Jia, Xiao Li, Jiankang He, Dichen Li   +8 more
openaire   +1 more source

The Microenvironment of Solid Tumors: Components and Current Challenges of Tumor-on-a-Chip Models

Tissue Engineering Part B: Reviews
Solid tumors represent the most common type of cancer in humans and are classified into sarcomas, lymphomas, and carcinomas based on the originating cells. Among these, carcinomas, which arise from epithelial and glandular cells lining the body's tissues, are the most prevalent.
Ilva de Fátima, Souza, João Paulo de Jesus, Vieira, Elton Diêgo, Bonifácio, Bethânia Alves de, Avelar Freitas, Libardo Andres Gonzalez, Torres   +4 more
openaire   +2 more sources