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Tumor organoid and tumor-on-a-chip equipped next generation precision medicine
BiofabricationAbstract Recently, significant advancements have been witnessed in various in vitro treatment evaluation models, especially organoids and organs-on-chips. In vitro culture of cancer cells and drug screening are key technical components in functional oncology precision medicine. However, most studies primarily focus on constructing models
Wentao Zhao +8 more
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Tumor-on-a-chip devices for cancer immunotherapy
2022Xuan Mu, Yu Shrike Zhang
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New insights in tumor-on-a-chip models for studying cancer drug resistance
Pathology - Research and PracticeCancer presents significant challenges due to its high incidence, frequent recurrence, elevated mortality, and generally poor prognosis, making it a serious threat to human life and an obstacle to societal progress. A major difficulty in cancer treatment is the development of drug resistance, which undermines the effectiveness of therapies and limits ...
Yunbo Wang +13 more
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Computational model of the cancer necrotic core formation in a tumor-on-a-chip device
Journal of Theoretical BiologyThe mechanisms underlying the formation of necrotic regions within avascular tumors are complex and poorly understood. In this paper, we investigate the formation of a necrotic core in a 3D tumor cell culture within a microfluidic device, considering oxygen, nutrients, and the microenvironment acidification by means of a computational-mathematical ...
Bonifácio, Elton Diêgo +6 more
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Channel-assembling tumor microenvironment on-chip for evaluating anticancer drug efficacy
Journal of Controlled ReleaseOrgan-on-a-chip is an advanced system for evaluating drug response in diseases. It simulates the in vivo tumor microenvironment, aiding in the understanding of drug mechanisms and tumor responses. It mimics the structure of the tumor microenvironment and the dynamic conditions within the body.
Jaehun, Lee +4 more
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Immunocompetent tumor-on-a-chip: A translational tool for drug screening and cancer therapy
Critical Reviews in Oncology/HematologyTumor is one of the major diseases endangering human health while establishing an efficient in vitro tumor microenvironment (TME) model, which is an effective way to reveal the nature of the tumor and develop therapeutic methods. In recent years, due to the continuous development of lab-on-a-chip technology and tumor biology, various tumor-on-a-chip ...
Anqi Liang +6 more
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Tumor-on-a chip in 3D microfluidic device for immunotherapy study
Extended Abstracts of the 2022 International Conference on Solid State Devices and Materials, 2022Yu-Chen - Chen +6 more
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Advanced Therapeutics
Abstract Vascularized tumor on a chip (VToC) entail emulating intricate microvascular networks like those observed in tumors through microfluidic devices, which are meticulously designed to offer a faithful representation of cancer in vitro, exploration of tumor biology, evaluation of drug efficacy, and anticipation of patient ...
Pratibha Parihar +5 more
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Abstract Vascularized tumor on a chip (VToC) entail emulating intricate microvascular networks like those observed in tumors through microfluidic devices, which are meticulously designed to offer a faithful representation of cancer in vitro, exploration of tumor biology, evaluation of drug efficacy, and anticipation of patient ...
Pratibha Parihar +5 more
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Clinical Utility of Solid Tumor Epigenetics
Medical Epigenetics, 2021Sevin Turcan, Julian Taranda
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Brain and Other Central Nervous System Tumor Statistics, 2021
Ca-A Cancer Journal for Clinicians, 2021Rebecca L. Siegel +2 more
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