Results 41 to 50 of about 141,925 (244)
Frontiers in Cell and Developmental Biology, 2021 Pancreatic Ductal Adenocarcinoma (PDAC), the most common pancreatic cancer type, is believed to become the second leading cause of cancer-related deaths by 2030 with mortality rates of up to 93%.
Marlene Geyer, Karla Queiroz
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Chemotaxis-driven assembly of endothelial barrier in a tumor-on-a-chip platform [PDF]
Lab on a Chip, 2016 Chemotaxis-driven assembly of an endothelial barrier around tumor cells within a microfluidics device.
Aereas, Aung +3 more
openaire +2 more sources
Tumor-on-a-chip for integrating a 3D tumor microenvironment: chemical and mechanical factors. [PDF]
Lab Chip, 2020 Tumor progression is significantly influenced by factors such as mechanical force, shear stress, chemotaxis, and hypoxia. Here, we reviewed recent achievements and presented potential directions for tumor-on-a-chip systems in the future.
Wan L, Neumann CA, LeDuc PR.
europepmc +4 more sources
Three-Dimensional In Vitro Lymphangiogenesis Model in Tumor Microenvironment
Frontiers in Bioengineering and Biotechnology, 2021 Lymphangiogenesis is a stage of new lymphatic vessel formation in development and pathology, such as inflammation and tumor metastasis. Physiologically relevant models of lymphatic vessels have been in demand because studies on lymphatic vessels are ...
Youngkyu Cho +9 more
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A Tumor-on-a-Chip System with Bioprinted Blood and Lymphatic Vessel Pair. [PDF]
Adv Funct Mater, 2019 Abstract Current in vitro antitumor drug screening strategies insufficiently mimic biological systems. They tend to lack true perfusion and draining microcirculation systems, which may post significant limitations in explicitly reproducing the transport kinetics of cancer therapeutics.
Cao X +9 more
europepmc +4 more sources
An in vitro model of cancer invasion with heterogeneous ECM created with droplet microfluidics
Frontiers in Bioengineering and Biotechnology, 2023 Metastasis is a multi-step process that is critically affected by cues from the tumor micro-environment (TME), such as from the extracellular matrix (ECM). The role of the ECM in the onset of metastasis, invasion, is not yet fully understood.
Mohammad Jouybar +10 more
doaj +1 more source
Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches
Disease Models & Mechanisms, 2018 Most cancer deaths are not caused by the primary tumor, but by secondary tumors formed through metastasis, a complex and poorly understood process.
Jelle J. F. Sleeboom +4 more
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Tumor-on-a-chip: a microfluidic model to study cell response to environmental gradients. [PDF]
Lab Chip, 2019 Limited blood supply and rapid tumor metabolism within solid tumors leads to nutrient starvation, waste product accumulation and the generation of pH gradients across the tumor mass.
Ayuso JM +9 more
europepmc +4 more sources
3D cancer models: One step closer to in vitro human studies
Frontiers in Immunology, 2023 Cancer immunotherapy is the great breakthrough in cancer treatment as it displayed prolonged progression-free survival over conventional therapies, yet, to date, in only a minority of patients.
Nicoletta Manduca +5 more
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Frontiers in Cellular Neuroscience, 2020 Glioblastoma (GBM) is the most common and devastating primary brain tumor, leading to a uniform fatality after diagnosis. A major difficulty in eradicating GBM is the presence of microscopic residual infiltrating disease remaining after multimodality ...
Henry Ruiz-Garcia +6 more
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