Results 21 to 30 of about 141,925 (244)

Tumor-on-a-chip: from bioinspired design to biomedical application. [PDF]

Microsyst Nanoeng, 2021
AbstractCancer is one of the leading causes of human death, despite enormous efforts to explore cancer biology and develop anticancer therapies. The main challenges in cancer research are establishing an efficient tumor microenvironment in vitro and exploring efficient means for screening anticancer drugs to reveal the nature of cancer and develop ...
Liu X, Fang J, Huang S, Wu X, Xie X, Wang J, Liu F, Zhang M, Peng Z, Hu N.   +9 more
europepmc   +5 more sources

From Spheroids to Tumor-on-a-Chip for Cancer Modeling and Therapeutic Testing. [PDF]

Micromachines (Basel)
The high failure rate of anticancer drugs in clinical trials highlights the need for preclinical models that accurately reproduce the structural, biochemical, and mechanical complexity of human tumors. Conventional two-dimensional cultures and animal models often lack the physiological complexity required to predict clinical outcomes, driving the ...
Lipreri MV, Totaro MT, Baldini N, Avnet S.   +3 more
europepmc   +5 more sources

Magnetic hyperthermia therapy in glioblastoma tumor on-a-Chip model. [PDF]

Einstein (Sao Paulo), 2020
To evaluate the magnetic hyperthermia therapy in glioblastoma tumor-on-a-Chip model using a microfluidics device.The magnetic nanoparticles coated with aminosilane were used for the therapy of magnetic hyperthermia, being evaluated the specific absorption rate of the magnetic nanoparticles at 300 Gauss and 305kHz. A preculture of C6 cells was performed
Mamani JB, Marinho BS, Rego GNA, Nucci MP, Alvieri F, Santos RSD, Ferreira JVM, Oliveira FA, Gamarra LF.   +8 more
europepmc   +7 more sources

Glioma-on-a-Chip Models

Micromachines, 2021
Glioma, as an aggressive type of cancer, accounts for virtually 80% of malignant brain tumors. Despite advances in therapeutic approaches, the long-term survival of glioma patients is poor (it is usually fatal within 12–14 months).
Merve Ustun, Sajjad Rahmani Dabbagh, Irem Sultan Ilci, Tugba Bagci-Onder, Savas Tasoglu   +4 more
doaj   +1 more source

Engineered Vasculature for Organ-on-a-Chip Systems

Engineering, 2022
Organ-on-a-chip technology, a promising three-dimensional (3D) dynamic culture method, ensures accurate and efficient cell culture and has great potential for replacing animal models in preclinical testing. The circulatory system, the most abundant organ
Abdellah Aazmi, Hongzhao Zhou, Yuting Li, Mengfei Yu, Xiaobin Xu, Yutong Wu, Liang Ma, Bin Zhang, Huayong Yang   +8 more
doaj   +1 more source

Organ-on-a-chip Technology in Urology

Креативная хирургия и онкология, 2023
Organs-on-chips (OOC) refer to microfluidic devices used to create biomimetic systems of physiological organs. The system contains engineered or natural miniature tissues grown inside microfluidic chips.
A. G. Vardikian, S. V. Piatnitskaia, V. A. Solntsev, B. I. Shamsov, V. N. Pavlov   +4 more
doaj   +1 more source

Microfluidic Tumor-on-a-Chip Model to Study Tumor Metabolic Vulnerability. [PDF]

Int J Mol Sci, 2020
Tumor-specific metabolic adaptations offer an interesting therapeutic opportunity to selectively destroy cancer cells. However, solid tumors also present gradients of nutrients and waste products across the tumor mass, forcing tumor cells to adapt their metabolism depending on nutrient availability in the surrounding microenvironment.
Ayuso JM, Rehman S, Farooqui M, Virumbrales-Muñoz M, Setaluri V, Skala MC, Beebe DJ.   +6 more
europepmc   +4 more sources

Tumor-on-a-chip platform to interrogate the role of macrophages in tumor progression. [PDF]

Integr Biol (Camb), 2020
Abstract Tumor-infiltrating leukocytes, in particular macrophages, play an important role in tumor behavior and clinical outcome. The spectrum of macrophage subtypes ranges from antitumor “M1”-type to protumor “M2”-type macrophages.
Bi Y, Shirure VS, Liu R, Cunningham C, Ding L, Meacham JM, Goedegebuure SP, George SC, Fields RC.   +8 more
europepmc   +6 more sources

Analysis of Static Molecular Gradients in a High-Throughput Drug Screening Microfluidic Assay

Molecules, 2021
In this study, we thoroughly analyzed molecular gradient generation, its stability over time, and linearity in our high-throughput drug screening microfluidic assay (HTS).
Roman G. Szafran, Benita Wiatrak
doaj   +1 more source

Mechanical cues in tumor microenvironment on chip

Biosensors and Bioelectronics: X, 2023
Mechanical cues from the tumor microenvironment (TME) can influence cell behaviors and have been indicated to play a pivotal role in tumor initiation, progression, and metastasis. The integration of microfluidics technologies, bioelectronics, and tissue engineering approaches have allowed the development of various in-vitro TME on-chip models.
Zhiru Zhou, Theadora Vessella, Pengbo Wang, Feiyun Cui, Qi Wen, Hong Susan Zhou   +5 more
openaire   +2 more sources