Recent advances in vascularized tumor-on-a-chip [PDF]
Frontiers in Oncology, 2023 The vasculature plays a critical role in cancer progression and metastasis, representing a pivotal aspect in the creation of cancer models. In recent years, the emergence of organ-on-a-chip technology has proven to be a robust tool, capable of ...
Christina Bao Xian Huang +3 more
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Diversity Models and Applications of 3D Breast Tumor-on-a-Chip [PDF]
Micromachines, 2021 Breast disease is one of the critical diseases that plague females, as is known, breast cancer has high mortality, despite significant pathophysiological progress during the past few years.
Kena Song +5 more
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Tumor-on-a-chip: Perfusable vascular incorporation brings new approach to tumor metastasis research and drug development [PDF]
Frontiers in Bioengineering and Biotechnology, 2022 The extracellular matrix interacts with cancer cells and is a key factor in the development of cancer. Traditional two-dimensional models cannot mimic the natural in situ environment of cancer tissues, whereas three-dimensional (3D) models such as ...
Ruixin Wang +3 more
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3D-Printed Tumor-on-a-Chip Model for Investigating the Effect of Matrix Stiffness on Glioblastoma Tumor Invasion [PDF]
Biomimetics, 2023 Glioblastoma multiform (GBM) tumor progression has been recognized to be correlated with extracellular matrix (ECM) stiffness. Dynamic variation of tumor ECM is primarily regulated by a family of enzymes which induce remodeling and degradation.
Meitham Amereh +5 more
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Recapitulating Solid Stress on Tumor on a Chip for Nanomedicine Diffusive Transport Prediction
Advanced NanoBiomed Research, 2023 The characteristic mechanical forces at play within tumors include the abnormal solid and fluid stresses. These, together with the increased extracellular matrix (ECM) stiffness, are the major transport barriers affecting the nanomedicine delivery to ...
Alberto Martín-Asensio +8 more
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Hybrid-integrated devices for mimicking malignant brain tumors (“tumor-on-a-chip”) for in vitro development of targeted drug delivery and personalized therapy approaches [PDF]
Frontiers in MedicineAcute and requiring attention problem of oncotheranostics is a necessity for the urgent development of operative and precise diagnostics methods, followed by efficient therapy, to significantly reduce disability and mortality of citizens.
Tatiana M. Zimina +6 more
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An Advanced 3D Model of Vascularized Epithelial Ovarian Cancer in a Tumor-on-a-Chip System Based on Multi-Cell Culture [PDF]
SensorsEpithelial ovarian cancer (EOC) is a highly lethal malignancy characterized by significant heterogeneity and poor prognosis due to late-stage diagnosis and chemotherapy resistance.
Magdalena Flont +7 more
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Tumor-on-a-chip model for advancement of anti-cancer nano drug delivery system [PDF]
Journal of Nanobiotechnology, 2022 Despite explosive growth in the development of nano-drug delivery systems (NDDS) targeting tumors in the last few decades, clinical translation rates are low owing to the lack of efficient models for evaluating and predicting responses.
Chutong Tian +3 more
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Metabolic Switching of Tumor Cells under Hypoxic Conditions in a Tumor-on-a-chip Model [PDF]
Micromachines, 2020 Hypoxia switches the metabolism of tumor cells and induces drug resistance. Currently, no therapeutic exists that effectively and specifically targets hypoxic cells in tumors.
Valentina Palacio-Castañeda +4 more
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Organ-Tumor-on-a-Chip for Chemosensitivity Assay: A Critical Review [PDF]
Micromachines, 2016 With a mortality rate over 580,000 per year, cancer is still one of the leading causes of death worldwide. However, the emerging field of microfluidics can potentially shed light on this puzzling disease.
Navid Kashaninejad +7 more
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